Locally Advanced Rectal Cancer: MR Imaging in Prediction of Response after Preoperative Chemotherapy and Radiation Therapy

Abstract

http://radiology.rsnajnls.org/cgi/content/full/250/3/730/DC1.

Novel Carcinoembryonic-Antigen-(CEA)-Specific Pretargeting System to Assess Tumor Cell Viability after Irradiation of Colorectal Cancer Cells

“…These methods are not able to distinguish tumor from necrotic and/or fibrotic tissue. Furthermore, the extent of RCTinduced cancer death combined with shrinkage of the initial tumor infiltration depth can not be determined [1]. Other imaging methods like 18 FDG ([ 18 F]fluoro-2-deoxy-D-glucose) positron emission tomography (FDG-PET/CT) seem to be useful in management of colorectal cancer [3,28,29].…”

MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer

“…In addition, a studyspecific MRI was performed after NACT and the first three RT fractions, MRI NACT . The median time from MRI PRE to the start of NACT was 5 days (range, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], and the median time from MRI CRT to surgery was 20 days (range, 7-98). 41 of the study patients were imaged using a 1.5-T GE Signa® LS scanner (GE Healthcare, Milwaukee, WI) with a phased-array torso coil.…”

“…8,9 In LARC, MRI-based tumour volume changes have been investigated as a parameter of treatment response after the full course of CRT. [10][11][12][13][14] Recognizing the dose-volume relationship, 15 it is anticipated that small tumour volume at the time of CRT is correlated to good treatment response. To our knowledge, the potential of MRI volumetry after NACT alone has been explored only in two studies; a pilot study of 16 patients 16 and a recent study of 40 patients; 17 the latter also assessing the performance of fluorine-18 fludeoxyglucose positron emission tomography ( 18 F-FDG-PET).…”

Radiotherapy and Chemoradiation for Rectal Cancer: State of the Art in Europe, the USA and Asia

“…There is an increasing experience in evaluating tumour response by repeat MRI or PET-CT. Using MRI, decrease in size can be seen as well as increase in fi brosis and mucous degeneration indicating response [ 64 ]. Using FDG-PET, decrease in uptake can be seen [ 65 -68 ].…”