MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer

Seierstad, Therese; Hole, Knut Håkon; Grøholt, Krystyna; Dueland, Svein; Ree, Anne Hansen; Flatmark, Kjersti; Redalen, Kathrine Røe

doi:10.1259/bjr.20150097

Cited by 23 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of rectal cancer, there have been several reports showing the usefulness of CT or MR volumetry to predict treatment response after chemoradiation therapy [12–15]. However, to the best of our knowledge, there have been no reports that investigate the feasibility and usefulness of CTC volumetric evaluation to predict TNM staging and patients’ prognosis.…”

Section: Introductionmentioning

confidence: 99%

CT volumetric measurement of colorectal cancer helps predict tumor staging and prognosis

et al. 2017

View full text Add to dashboard Cite

PurposeTo evaluate feasibility of CT colonography (CTC) volumetry of colorectal cancer (CRC) and its correlation with disease stage and patients’ survival.Materials and methodsCTC volumetry was performed for 126 patients who underwent preoperative CTC. Reproducibility of tumor volume (Tvol) between two readers was assessed. One-way ANOVA and ROC analysis evaluated correlation between Tvol and pTNM staging. ROC analysis compared diagnostic performance to predict pTNM staging between Tvol and radiologist. Kaplan-Meier test compared overall survival.ResultsReproducibility among readers was excellent (interclass correlation = 0.9829). Mean Tvol showed an incremental trend with T stage and Tvol of pT4b stage was significantly larger than other stages (P<0.0001). Az value (0.780) of Tvol to predict pT4b stage was significantly larger than that (0.591) of radiologist (P = 0.004). However, Tvol was not significantly different according to pN stage. Az values (0.723~0.857) of Tvol to predict M1 or M1b were comparable to those (0.772~0.690) of radiologist (P>0.05). Smaller tumor burden (≤12.85cm3), ≤T3, N0, M0 stages, and curative surgery were significantly associated with patients’ longer survival (P<0.05).ConclusionCT volumetry has a limited value to predict N stage; however, it may outperform the radiologist’s performance when predicting pT4b and M1b stage and can be a useful prognostic marker.

show abstract

Section: Introductionmentioning

confidence: 99%

CT volumetric measurement of colorectal cancer helps predict tumor staging and prognosis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Tumour volumetry estimates reduction in mass of the tumour between baseline and after treatment; it has been hypothesized to be a marker of tumour regression as a whole . This can be done by one‐dimensional, two‐dimensional or three‐dimensional measurements.…”

Section: Techniques To Assess Tumour Responsementioning

confidence: 99%

“…Whilst tumour volumetry and T2-weighted imaging (mrTRG) have been validated against patient outcomes, many of the other techniques have not undergone validation and therefore remain experimental. Tumour volumetry estimates reduction in mass of the tumour between baseline and after treatment; it has been hypothesized to be a marker of tumour regression as a whole [11]. This can be done by one-dimensional, two-dimensional or three-dimensional measurements.…”

Section: Techniques To Assess Tumour Responsementioning

confidence: 99%

Session 3: Beyond TME and radiotherapy MRI evaluation of rectal cancer treatment response

et al. 2018

View full text Add to dashboard Cite

Magnetic resonance imaging plays an increasingly important role in evaluating the effect of cancer treatment. Imaging alone cannot predict pathological complete response and imaging interpretation should be combined with clinical information and endoscopy findings to predict complete response. Professor Blomqvist reviews current and future imaging techniques and whether the quantitative can add significant or important prognostic information over the current qualitative techniques.

show abstract

“…These include morphological changes assessed in terms of MRI tumour regression grade (mrTRG) and volumetry, or functional changes using diffusion‐weighted imaging (DWI) and dynamic contrast‐enhanced MRI. Tumour volume is a strong predictor of tumour response and outcome, especially when combined with DWI. The advantage of T2‐weighted imaging (T2WI)–DWI volumetry is that it capitalizes on tumour biology rather than relying solely on morphological appearance, thus better differentiating postradiation fibrosis from residual tumour.…”

Section: Introductionmentioning

confidence: 99%

Early MRI predictors of disease-free survival in locally advanced rectal cancer from the GRECCAR 4 trial

Nougaret

Castan

Forges

et al. 2019

British Journal of Surgery

View full text Add to dashboard Cite

Background: Tailored neoadjuvant treatment of locally advanced rectal cancer (LARC) may improve outcomes. The aim of this study was to determine early MRI prognostic parameters with which to stratify neoadjuvant treatment in patients with LARC.Methods: All patients from a prospective, phase II, multicentre randomized study (GRECCAR4; NCT01333709) were included, and underwent rectal MRI before treatment, 4 weeks after induction chemotherapy and after completion of chemoradiotherapy (CRT). Tumour volumetry, MRI tumour regression grade (mrTRG), T and N categories, circumferential resection margin (CRM) status and extramural vascular invasion identified by MRI (mrEMVI) were evaluated.Results: A total of 133 randomized patients were analysed. Median follow-up was 41⋅4 (95 per cent c.i. 36⋅6 to 45⋅2) months. Thirty-one patients (23⋅3 per cent) developed tumour recurrence. In univariable analysis, mrEMVI at baseline was the only prognostic factor associated with poorer outcome (P = 0⋅015). After induction chemotherapy, a larger tumour volume on MRI (P = 0⋅019), tumour volume regression of 60 per cent or less (P = 0⋅002), involvement of the CRM (P = 0⋅037), mrEMVI (P = 0⋅026) and a poor mrTRG (P = 0⋅023) were associated with poor outcome. After completion of CRT, the absence of complete response on MRI (P = 0⋅004), mrEMVI (P = 0⋅038) and a poor mrTRG (P = 0⋅005) were associated with shorter disease-free survival. A final multivariable model including all significant variables (baseline, after induction, after CRT) revealed that Eastern Cooperative Oncology Group performance status (P = 0⋅011), sphincter involvement (P = 0⋅009), mrEMVI at baseline (P = 0⋅002) and early tumour volume regression of 60 per cent or less after induction (P = 0⋅007) were associated with relapse.Conclusion: Baseline and early post-treatment MRI parameters are associated with prognosis in LARC. Future preoperative treatment should stratify treatment according to baseline mrEMVI status and early tumour volume regression.

show abstract

MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer

Cited by 23 publications

References 32 publications

CT volumetric measurement of colorectal cancer helps predict tumor staging and prognosis

CT volumetric measurement of colorectal cancer helps predict tumor staging and prognosis

Session 3: Beyond TME and radiotherapy MRI evaluation of rectal cancer treatment response

Early MRI predictors of disease-free survival in locally advanced rectal cancer from the GRECCAR 4 trial

Contact Info

Product

Resources

About