Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption

Ukai, Takashi; Yamaguchi, Masayuki; Yokoyama, M; Haro, Esperanza R. Ayón; Yoshimoto, Mayumi; Kaneko, Takashi; Yoshinaga, M; Nakamura, H.; Shiraishi, Chiaki; Hara, Yoshitaka

doi:10.1016/j.bone.2009.01.375

Cited by 29 publications

(20 citation statements)

References 44 publications

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“…Moreover, LPS-pulsed splenocytes enhanced OCL differentiation, confirming that inflammatory environment lead to bone destruction as a serious complication of bacterial infections of bones or adjacent tissues [6,9,[12][13][14][15][16]37]. In conclusion, our results demonstrate that there is a bidirectional communication during endotoxin-induced inflammation between bone and immune cells.…”

Section: Discussionsupporting

confidence: 66%

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Chemotactic and Immunoregulatory Properties of Bone Cells are Modulated by Endotoxin-Stimulated Lymphocytes

et al. 2012

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Section: Discussionsupporting

confidence: 66%

“…B lymphocytes, highly susceptible to LPS, additionally contribute to osteoclastogenic effect of LPS in vitro and in vivo [13][14]. T lymphocytes within an inflamed site support bone destruction by stimulating RANKL expression and OCL precursors [15][16].…”

Section: Introductionmentioning

confidence: 99%

Chemotactic and Immunoregulatory Properties of Bone Cells are Modulated by Endotoxin-Stimulated Lymphocytes

et al. 2012

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“…Only a few constituents of GCF production are closely related to inflammation reaction after flapless implant surgery, such as aspartate transferase, alkaline phosphatase, and endotoxin. Endotoxin has been associated invariably with Gram‐negative bacteria and identified as a major bacterial bone‐resorbing factor 25 , 26 . Crevicular LPS concentrations influenced peri‐implant inflammation with increased levels of proinflammatory cytokines in PICF 27 .…”

Section: Discussionmentioning

confidence: 99%

Effects of Topical Antibiotic Prophylaxis on Wound Healing After Flapless Implant Surgery: A Pilot Study

Wang

Nguyen

et al. 2016

Journal of Periodontology

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The local application of antibiotics along with the systemic antibiotics could reduce the inflammatory response in wound healing after implant surgery. The EEO and MHO were equally effective in early wound healing. Compared to the MHO, the EEO has advantages of higher cost efficiency and convenience. Therefore, it is recommended to use the EEO in topical antibiotic prophylaxis for wound healing after flapless implant surgery.

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“…A number of studies have demonstrated that LPS from gram-negative bacteria was capable of inducing bone resorption in vivo 14–18 . Therefore, modulating MAPK immune response to an appropriate level is essential to attenuate bone resorption associated with bacterial infection.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss

Herbert

et al. 2010

Gene Ther

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Alveolar bone loss associated with periodontal diseases is the result of osteoclastogenesis induced by bacterial pathogens. The mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP- 1) is a critical negative regulator of immune response as a key phosphatase capable of dephosphorylating activated MAPKs. In this study, rat macrophages transduced with recombinant adenovirus (Ad).MKP-1 specifically dephosphorylated activated MAPKs induced by lipopolysaccharide (LPS) compared with control cells. Bone marrow macrophages from MKP-1 knockout (KO) mice exhibited higher interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and select chemokine compared with wild type (WT) mice when stimulated by LPS. In addition, bone marrow cultures from MKP-1 KO mice exhibited significantly more osteoclastogenesis induced by LPS compared with WT mice. Importantly, MKP-1 gene transfer in bone marrow cells of MKP-1 KO mice significantly decreased IL-6, IL-10, TNF-α, chemokine levels and formed fewer osteoclasts induced by LPS compared with control group of cells. Furthermore, MKP-1 gene transfer in an experimental periodontal disease model attenuated bone resorption induced by LPS. Histological analysis confirmed that periodontal tissues transduced with Ad.MKP-1 exhibited less infiltrated inflammatory cells, less osteoclasts and less IL-6 compared with rats of control groups. These studies indicate that MKP-1 is a key therapeutic target to control of inflammation-induced bone loss.

show abstract

Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption

Cited by 29 publications

References 44 publications

Chemotactic and Immunoregulatory Properties of Bone Cells are Modulated by Endotoxin-Stimulated Lymphocytes

Chemotactic and Immunoregulatory Properties of Bone Cells are Modulated by Endotoxin-Stimulated Lymphocytes

Effects of Topical Antibiotic Prophylaxis on Wound Healing After Flapless Implant Surgery: A Pilot Study

Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss

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