Effects of Topical Antibiotic Prophylaxis on Wound Healing After Flapless Implant Surgery: A Pilot Study

Xu, Li; Wang, Yuanyuan; Nguyen, Van Tuan; Chen, Jiangang

doi:10.1902/jop.2015.150464

Cited by 13 publications

(18 citation statements)

References 23 publications

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“…The signi icant wound healing activity revealed due to their ability for decreasing the response of in lammation at the wound area. The result was come in accordance with [31] they found that local application of antibiotics could reduce the in lammatory response in wound healing. Also this result come in accordance with [32] about the role of Rapamycin on Wound Healing in wound healing as affected all steps of the wound healing process by decreasing the in lammatory cell number, angiogenesis, and myo ibroblast proliferation.…”

Section: Discussionsupporting

confidence: 84%

Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic)

Fia¹

2017

Insights Vet Sci

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Tilmicosin (TMC) is a semi synthetic macrolide antibiotic of tylosin derivatives commonly used by veterinaries, has been shown to reveal benefi cial pharmacological activities. In the current study, the potential wound healing activity, Anti-oxidant effect (ulcer and hepatoprotective) were investigated. Anti-infl ammatory, antipyretic, analgesic (central and peripheral), hypnotic and antispasmodic activity were also screened. This study included adult both sexes of rats (200-250 gm), mice (20-25 gm) and adult rabbits. Experimental wound was induced on the anterior-dorsal side of each rat whereas, ulcer induced by ethanol causing mucosal damage in rats. The oral anti-infl ammatory induced through formalin producing edema, antipyretic (Brewer's yeast induced hyperthermia) and analgesic (writhing test, hot plate method, tail immersion method) while hypnotic effects induced through thiopental sodium. Anti-spasmodic effect on isolated organs (intestinal and uterine muscles) using new method of Modular Single Chamber Organ Bath were carried out on experimental animals. Tilmicosin antibiotic at different two doses of 20 and 40 mg/kg b.wt., has an important role in treatment of ulcer (cytoprotective effect) and improvement the wound healing processes besides anti-infl ammatory, analgesics, and anti-pyretic effects. Tilmicosin revealed also hypnotic and intestinal anti-spasmodic effects but showed Pharmacovigilence hepatotoxic effect through the histopathological studies which revealed sever hepatic damage especially at larger dose.How to cite this article: El-Ela FIA, El-Banna HA. Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic).

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Section: Discussionsupporting

confidence: 84%

Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic)

Fia¹

2017

Insights Vet Sci

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“…Azithromycin seemed to alter some potentially important aspects of inflammation, suggesting azithromycin may have a favorable influence on healing compared with amoxicillin. Moreover, Xu et al 32 recently found the local application of topical antibiotics combined with systemic antibiotic therapy reduced inflammation postoperatively and could enhance early wound healing after flapless implant surgery. A summary of the findings in the literature regarding the use of prophylactic antibiotics for dental implant placement is provided in Table 1.…”

Section: Clinical Methodsmentioning

confidence: 99%

“…Xu et al 32 Pilot Systemic antibiotic (not described) combined with topical application:1) MHO or 2) EEO or systemic antibiotic without topical application The local application of antibiotics along with systemic antibiotics could reduce the inflammatory response in wound healing after flapless implant surgery.…”

Section: Decrease Early Peri-implant Inflammationmentioning

confidence: 99%

Should Perioperative Antibiotics Be Prescribed Prophylactically for Uncomplicated Single Implant Surgeries?

Reddy

Brock

Coleman

et al. 2017

Clin Adv Periodontics

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Type of Case: A 32‐year‐old female presents missing tooth #5 and requesting replacement with a dental implant. She has an unremarkable medical history. The tooth #5 site is a healed ridge with adequate bone to support an implant without additional augmentation. Clinical Approach #1 (CMR and TMJ): This approach involves routine implant surgery with placement of a healing abutment. Preoperative management includes 2 g amoxicillin 1 hour prior to the procedure and postoperative pain medication. The rationale for use of an antibiotic is to decrease the risk of infection and implant failure and to reduce peri‐implant inflammation during early healing. The desired effect of the antibiotic is to minimize or eliminate the negative effects of bacteria in the wound site and on the implant surface during healing. This clinical approach is recommended to protect the investment of resources and time by the patient and dental team for optimal treatment outcomes. Clinical Approach #2 (AWB, BGC, and KJE): This approach involves routine implant surgery with placement of a healing abutment. Postoperative management includes pain medications without antibiotic use. The rationale for avoidance of antibiotics is to eliminate risk of an adverse drug reaction such as urticaria, anaphylaxis, or gastrointestinal disturbances. Because the evidence justifying antibiotic coverage is considered to be weak, clinicians are advised to consider withholding antibiotic prescriptions for routine implant placement as a means of risk mitigation for the patient and public health in general.

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“…Xu et al expressed concerns about the difficulty of limited information available to practitioners for stringent control of post-operative complications following implant procedures. 2 Furthermore, current literature demonstrates significant variability among practitioners' antibiotic prescribing patterns, prompting the need to assess how varying interventions affect the overall success of implant operations. 3 Dental implants generally exhibit high initial success rates, but failures occur occasionally.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic prophylaxis for implant placement: a systematic review of effects on reduction of implant failure

et al. 2020

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Effects of Topical Antibiotic Prophylaxis on Wound Healing After Flapless Implant Surgery: A Pilot Study

Cited by 13 publications

References 23 publications

Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic)

Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic)

Should Perioperative Antibiotics Be Prescribed Prophylactically for Uncomplicated Single Implant Surgeries?

Antibiotic prophylaxis for implant placement: a systematic review of effects on reduction of implant failure

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