Localized retinal ischemia as an ocular manifestation of primary antiphospholipid syndrome

Zajdenweber, Moysés Eduardo; Muccioli, Cristina; Moraes, Remo Turchetti; Logan, Patrick; Fernandes, Bruno F.; Burnier, Miguel N

doi:10.3129/can.j.ophthalmol.i07-071

“…If these antibodies are present in the absence of another recognizable autoimmune disease, however, the syndrome is known as primary antiphospholipid syndrome (APS) (1) . The ocular vascular damage is described in the literature and may reveal the syndrome.…”

Section: Introductionmentioning

confidence: 99%

Antiphospholipid syndrome and retinal vein occlusion

Costa¹,

Almeida

²

,

Campos

³

et al. 2009

Rev. bras.oftalmol.

0

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A 34-year-old white man presented with a sudden unilateral recurrent visual loss. Fundus examination and fluorescein angiography revealed severe retinal vein occlusion. An antiphospholipid syndrome was discovered during etiological check up. A mutation of Leiden V factor was discovered and the patient started long term anticoagulation after the second occlusive event. However, secondary neovascular glaucoma has developed and despite treatment the affected eye had an important reduction of visual acuity. The purpose of this case report is to demonstrate that retinal vascular occlusion can be the initial manifestation of the antiphospholipid syndrome and that its diagnosis is important because this disease generally affects young people and may endanger ocular and vital prognosis. This diagnosis may imply a long lasting anticoagulative or antiaggregative treatment to reduce the risk of recurrent thrombotic events.

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Ocular manifestations of the antiphospholipid syndrome

Utz

¹

,

Tang

²

2010

British Journal of Ophthalmology

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Antiphospholipid syndrome (APS) is an autoimmune disease characterised by a heterogenous group of antibodies directed against negatively charged phospholipids including antiphospholipid antibodies (aPL), anticardiolipin antibodies (aCL) and β-2 glycoprotein I (aβ-2-GP1). The major features of this disorder include arterial and venous thrombosis and recurrent fetal loss. The vasculature of the eye is frequently involved and may be the presenting manifestation. A diagnosis of APS should be considered in a young patients without traditional thromboembolic risk factors presenting with ocular vaso-occlusive disease. Management of these patients involves a team-approach with a haematologist/oncologist or rheumatologist to manage the coagulation status of these patients to prevent further systemic vascular occlusions.

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Republished review: Ocular manifestations of the antiphospholipid syndrome

Utz

¹

,

Tang

²

2011

Postgraduate Medical Journal

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Antiphospholipid syndrome (APS) is an autoimmune disease characterised by a heterogenous group of antibodies directed against negatively charged phospholipids including antiphospholipid antibodies (aPL), anticardiolipin antibodies (aCL) and β-2 glycoprotein I (aβ-2-GP1). The major features of this disorder include arterial and venous thrombosis and recurrent fetal loss. The vasculature of the eye is frequently involved and may be the presenting manifestation. A diagnosis of APS should be considered in a young patients without traditional thromboembolic risk factors presenting with ocular vaso-occlusive disease. Management of these patients involves a team-approach with a haematologist/oncologist or rheumatologist to manage the coagulation status of these patients to prevent further systemic vascular occlusions.

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Localized retinal ischemia as an ocular manifestation of primary antiphospholipid syndrome

Cited by 3 publications

References 5 publications

Antiphospholipid syndrome and retinal vein occlusion

Antiphospholipid syndrome and retinal vein occlusion

Ocular manifestations of the antiphospholipid syndrome

Republished review: Ocular manifestations of the antiphospholipid syndrome

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