Localized hypertrophic neuropathy: Magnetic resonance imaging findings and long-term follow-up

Simmons, Zachary; Mahadeen, Ziad I.; Kothari, Milind J.; Powers, Stephen K.; Wise, Scott W.; Towfighi, Javad

doi:10.1002/(sici)1097-4598(199901)22:1<28::aid-mus6>3.0.co;2-h

Cited by 61 publications

(37 citation statements)

References 15 publications

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“…T1 images may show a segmental thickening of nerve with or without post-gadolinium enhancement [1,3,20,31]. The description usually includes T2-weighted hyperintensity [3,20,44,45,47]. As this is a rare entity with indistinct imaging features, it is not likely that diagnostic confidence can be arrived at based on imaging alone.…”

Section: Diagnostics: Imaging With Us and Mricontrasting

confidence: 66%

Intraneural Perineurioma of the Median Nerve: Case Report and Literature Review

Sachanandani

Brown

Zaidman

et al. 2009

Hand (New York, N,Y.)

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Intraneural perineurioma is a benign peripheral nerve sheath tumor of perineurial cell origin. We present the case of an intraneural perineurioma of the median nerve in a 23-year-old woman which posed a diagnostic challenge. Ultrasonography was found to be a quick, easy, and effective screening tool for identifying the source of the deficit followed by MRI to further elucidate the lesion. We discuss surgical management options for optimizing functional outcomes when addressing such lesions.

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Section: Diagnostics: Imaging With Us and Mricontrasting

confidence: 66%

Intraneural Perineurioma of the Median Nerve: Case Report and Literature Review

Sachanandani

Brown

Zaidman

et al. 2009

Hand (New York, N,Y.)

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“…Frequently the brachial plexus, and the peroneal, tibial, sciatic, radial, and median nerves are affected. Facial nerve and spinal root involvement has also been reported (7,9,11,13,16). …”

Section: Discussionmentioning

confidence: 99%

“…In the 15-year retrospective study of Gruen et al, it was reported that 6 of 14 patients with surgical treatment had pain (7). In our patient, the presence of severe neuropathic pain is different than in some articles on sciatic nerve hypertrophy (11,13). In addition to our patient, pain and tenderness that occur while pressing on the sciatic nerve trace were observed in the majority of patients.…”

Section: Ilhanlı I Et Al: Sciatic Hypertrophy With Klippel-trenaunaymentioning

confidence: 99%

Sciatic nerve hypertrophy with klippel trenaunay syndrome: a case report

Ilhanli¹,

Keskin²,

Arslan³

et al. 2014

Turkish Neurosurgery

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A 73-year-old female patient who had severe neuropathic pain due to sciatic nerve hypertrophy with the Klippel-Trenaunay Syndrome has been presented. Localized hypertrophic neuropathy is in one region and characterized by concentric proliferation of Schwann cells around the axon. It is very rare in the absence of generalized hypertrophic neuropathy. Very little is known about the etiology and the course of this neuropathy. Klippel-Trénaunay-Syndrome (KTS) is a rare syndrome characterized by hemangioma, abnormalities of the venous and lymphatic systems, and limb enlargement due to soft tissue and bone hypertrophy.

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“…Up to 44% of patients were children and the sciatic nerve was involved in 13% of the cases. Few authors have described the use of MRI in "localized hypertrophic neuropathy" due to perineural cell proliferation (EMA positive, S-100 negative) [6]. The differential diagnosis is chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), which is often symmetrical and multifocal; Guillain-Barré syndrome, where imaging is usually normal; and HMSN (hereditary motor and sensory neuropathy) III (Dejerine-Sottas disease), in which contrast enhancement is almost always absent.…”

Section: Discussionmentioning

confidence: 99%

“…Affected nerves are of higher signal than normal on T2-W images [6]. The 3-D T2-W STIR SPACE sequence combines the properties of fat-saturated T2-W images with better visualization of the spatial extension of the lesion within and along the nerve tracts due to large anatomical coverage and the ability to slice through the volume of interest.…”

Section: Discussionmentioning

confidence: 99%

MRI neurography and diffusion tensor imaging of a sciatic perineuroma in a child

et al. 2008

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Perineuroma, rare in children, presents as a painless mononeuropathy of a major nerve trunk. Resection of the lesion with end-to-end sural nerve grafting appears to be the treatment of choice. This technique is not recommended if the unhealthy segment of nerve is too long or if spinal roots are involved. However, in children, reports of direct MR evaluation of nerve trunks and of the exiting nerve roots are limited. We report a 7-year-old girl with an intramural sciatic nerve perineuroma in whom the diagnosis was made by MRI and confirmed by biopsy. The MR protocol combining 3-D T2-W STIR SPACE, fat-saturated gadolinium-enhanced T1-W images, and diffusion tensor imaging with tractography was a valuable tool for depicting peripheral nerve and roots in order to plan surgical treatment.

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Localized hypertrophic neuropathy: Magnetic resonance imaging findings and long-term follow-up

Cited by 61 publications

References 15 publications

Intraneural Perineurioma of the Median Nerve: Case Report and Literature Review

Intraneural Perineurioma of the Median Nerve: Case Report and Literature Review

Sciatic nerve hypertrophy with klippel trenaunay syndrome: a case report

MRI neurography and diffusion tensor imaging of a sciatic perineuroma in a child

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