Intraneural Perineurioma of the Median Nerve: Case Report and Literature Review

Sachanandani, Neil S.; Brown, Justin M.; Zaidman, Craig M.; Brown, Stephanie; Mackinnon, Susan E.

doi:10.1007/s11552-009-9228-1

Cited by 19 publications

(11 citation statements)

References 47 publications

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“…The full text of the remaining 57 articles was reviewed and 35 articles were then excluded. Therefore, 22 articles met the inclusion criteria [5,9,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31], comprising 74 cases of PN (Table 1).…”

Section: Results Of the Systematic Reviewmentioning

confidence: 99%

“…Sachanandani et al recommended as an alternative to proximal nerve grafting a distal nerve transfer in patients with progressive neuropathies due to several reasons. Widely resection of the lesion is possible using a nerve reconstruction that is distant to the lesion without any concern for the length of graft required [25]. Furthermore, reinnervation of the target musculature might be more successful to decreased length of regeneration required, elimination of an additional repair site, and exclusion of grafts [35].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, reinnervation of the target musculature might be more successful to decreased length of regeneration required, elimination of an additional repair site, and exclusion of grafts [35]. Additionally, harvesting a nerve graft using a second surgery site and possible causing further deficits may be avoided [25].…”

Section: Discussionmentioning

confidence: 99%

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Modern treatment of perineuriomas: a case-series and systematic review

et al. 2020

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Background: Perineuriomas are rare benign peripheral nerve sheath tumours of perineurial cell origin and can be classified into intraneural and extraneural perineuriomas. They most commonly present a mononeuropathy of gradual onset and slow progression, resulting in progressive neurological deficits like hypoesthesia or motor weakness. Therapy is still variable. Aim of the study was to compare our surgical treatment and our follow-up regime including high-resolution nerve sonography with the current literature to evaluate best treatment of perineuriomas. Methods: Retrospective analysis of our dataset "peripheral nerve lesion" to identify patients suffering from perineuriomas between 01.01.2012 until 31.12.2018. Surgical treatment and the follow-up examination of three patients were described. Additionally, a systematic review including PubMed, the Cochrane Collaboration Library, Scopus and Google Scholar was performed for literature published between January 1, 1990 and October 31, 2019 independently by 2 authors. Results: In the first case, the left ulnar nerve was affected. In the second case, the left peroneal nerve and in the third case the right median nerve was affected. High-resolution nerve sonography was performed in each case. All patients underwent interfascicular neurolysis combined with a targeted fascicular biopsy under electrophysiological monitoring. Neurological deficits improved subsidized by rehabilitation. Surgical therapy and the neurological outcome were compared with literature. Systematic review revealed 22 articles, which met the inclusion criteria. Therefore, demographics, surgical treatment and neurological outcome of 77 patients were analysed. Conclusions: Perineuriomas are rare benign nerve sheath tumours with a slow progression, sometimes difficult to diagnose. Decompression and neurolysis may improve neurological deficits. High resolution nerve sonography might serve as a helpful additional diagnostic tool in this process.

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Section: Results Of the Systematic Reviewmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Modern treatment of perineuriomas: a case-series and systematic review

et al. 2020

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“…We know four different types of perineurioma: soft tissue (extraneural), intraneural, sclerosing and reticular. The first type 3 is usually a subcutaneous lesion, the second 4 , 5 is a benign neoplasm characterized clinically by the fusiform swelling of a major nerve and usually characterized by a neurologic deficit. The third type is a benign, non-recurring, lesion which is a small solitary skin lesion.…”

Section: Discussionmentioning

confidence: 99%

Periprostatic Perineurioma, Description of a Case With Unusual Localization

Guerriero¹,

Pollio²,

Cuscunà³

et al. 2016

Urology Case Reports

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Perineurioma is a rare entity, it is a benign peripheral nerve sheath tumor entirely composed of perineurial cells. A 62-year-old male patient was admitted to our hospital, suffering from scrotal and pelvic pain combined with a severe and continuous pain in his right thigh. A transrectal ultrasound revealed a periprostatic oval lesion of about 5 cm in maximum diameter. A sovrapubic laparotomy was performed with a complete tumor excision. The morphological and immunohistochemical data were most consistent with the diagnosis of perineurioma.

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“…Patients typically present with a painless mononeuropathy, which includes progressive weakness throughout affected muscles, classically sparing sensation [6,11,16]. In the largest study to date, 29 patients presented with a chief complaint of weakness or atrophy and only three with numbness or pain.…”

Section: Discussion and Treatmentmentioning

confidence: 99%