Localized drug delivery with mono and bilayered mucoadhesive films and wafers for oral mucosal infections

Timur, Selin Seda; Yüksel, Selin; Akca, Gülçin; Şenel, Sevda

doi:10.1016/j.ijpharm.2019.01.029

Cited by 55 publications

(34 citation statements)

References 43 publications

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“…Mechanical properties of 2 cm × 3 cm films were characterized by tear resistance (TR), tensile strength (σ s ), percent of elongation at break (ε s ), and Young's (elastic) modulus (E) with using Texture Analyzer TA.XT. Plus (Stable Microsystems, Godalming, UK) at 25 ± 2 • C [11,[36][37][38]. While tear resistance and tensile strength represent the stress needed for film breaking, percent of elongation at break describes the possible material deformation until it tears.…”

Section: Physicomechanical Analysismentioning

confidence: 99%

Multilayer Films Based on Chitosan/Pectin Polyelectrolyte Complexes as Novel Platforms for Buccal Administration of Clotrimazole

et al. 2021

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Buccal films are recognized as easily applicable, microbiologically stable drug dosage forms with good retentivity at the mucosa intended for the therapy of oromucosal conditions, especially infectious diseases. Multilayer films composed of layers of oppositely charged polymers separated by ionically interacting polymeric chains creating polyelectrolyte complexes represent very interesting and relatively poorly explored area. We aimed to develop the antifungal multilayer systems composed of cationic chitosan and anionic pectin as potential platforms for controlled delivery of clotrimazole. The systems were pharmaceutically characterized with regard to inter alia their release kinetics under different pH conditions, physicomechanical, or mucoadhesion properties with using an animal model of the buccal mucosa. The antifungal activity against selected Candida sp. and potential cytotoxicity with regard to human gingival fibroblasts were also evaluated. Interactions between polyions were characterized with Fourier transform infrared spectroscopy. Different clotrimazole distribution in the films layers highly affected their in vitro dissolution profile. The designed films were recognized as intelligent pH-responsive systems with strong antifungal effect and satisfactory safety profile. As addition of chitosan resulted in the improved antifungal behavior of the drug, the potential utilization of the films in resistant cases of oral candidiasis might be worth of further exploration.

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Section: Physicomechanical Analysismentioning

confidence: 99%

Multilayer Films Based on Chitosan/Pectin Polyelectrolyte Complexes as Novel Platforms for Buccal Administration of Clotrimazole

et al. 2021

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“…Due to the specific anatomy, histology and prevailing dynamics in the oral cavity, polymer carriers, as multifunctional pharmaceutical excipients, should be characterized by specific features related to the persistence of the drug at the site of its administration, e.g., mucoadhesive properties, gradual swelling, a modified release of the active substance, a protective effect against mechanical stimulation and easy application [ 107 , 108 , 109 ]. To achieve these properties in clinical conditions, in addition to conventional forms, i.e., rinses, mucoadhesive tablets or gels, the use of active substance carriers in the form of modified formulations is proposed.…”

Section: Oral Applications Of Natural Polymersmentioning

confidence: 99%

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Paradowska-Stolarz

Więckiewicz

Owczarek

et al. 2021

IJMS

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The success of modern dental treatment is strongly dependent on the materials used both temporarily and permanently. Among all dental materials, polymers are a very important class with a wide spectrum of applications. This review aims to provide a state-of-the-art overview of the recent advances in the field of natural polymers used to maintain or restore oral health. It focuses on the properties of the most common proteins and polysaccharides of natural origin in terms of meeting the specific biological requirements in the increasingly demanding field of modern dentistry. The use of naturally derived polymers in different dental specialties for preventive and therapeutic purposes has been discussed. The major fields of application cover caries and the management of periodontal diseases, the fabrication of membranes and scaffolds for the regeneration of dental structures, the manufacturing of oral appliances and dentures as well as providing systems for oral drug delivery. This paper also includes a comparative characteristic of natural and synthetic dental polymers. Finally, the current review highlights new perspectives, possible future advancements, as well as challenges that may be encountered by researchers in the field of dental applications of polymers of natural origin.

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“…The advantage of wafers of films is reported to be low residual moisture and increased drug loading [181]. Recently, our group has developed monolayer and bilayered mucoadhesive film and wafer formulations as local drug delivery platforms for treatment of oral infections, using chitosan and hydroxypropyl methylcellulose (HPMC) [182]. Cefuroxime axetil (CA) was used as the model drug.…”

Section: Films and Wafersmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan²,

Akca

2021

Drug Deliv. and Transl. Res.

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Oral health reflects the general health, and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection-related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed, and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

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Localized drug delivery with mono and bilayered mucoadhesive films and wafers for oral mucosal infections

Cited by 55 publications

References 43 publications

Multilayer Films Based on Chitosan/Pectin Polyelectrolyte Complexes as Novel Platforms for Buccal Administration of Clotrimazole

Multilayer Films Based on Chitosan/Pectin Polyelectrolyte Complexes as Novel Platforms for Buccal Administration of Clotrimazole

Natural Polymers for the Maintenance of Oral Health: Review of Recent Advances and Perspectives

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

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