Localized Dielectric Loss Heating in Dielectrophoresis Devices

Kwak, Tae Joon; Hossen, Imtiaz; Bashir, Rashid; Chang, Woojin; Lee, Chung Hoon

doi:10.1038/s41598-019-55031-y

Cited by 26 publications

(24 citation statements)

References 46 publications

(42 reference statements)

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“…A range of methods, from conventional photolithography [ 62 , 63 ] to the latest 3D metal printing [ 64 , 65 ] technologies, for the fabrication of electrodes. The major drawbacks of using eDEP are Joule heating [ 27 , 31 , 32 , 33 ], fouling effects [ 33 ], and electrochemical reactions that generate toxic species mainly due to electrode disintegration [ 33 , 66 ]. Electrolysis and electro-osmotic effects can further hinder the cell and particle integrity.…”

Section: Discussionmentioning

confidence: 99%

“…The high gradient fields enable the manipulation of larger size particles, as the DEP force is directly proportional to the electric field strength and volume of the target particles [ 26 ]. However, larger gradients in eDEP induce Joule heating [ 27 ] and disintegrate electrodes which can lead to the generation of high amounts of toxic species, damaging to cells and cellular organelles [ 28 , 29 , 30 ]. More recently, iDEP has increased in popularity due to its efficacy towards manipulating cells and maintaining viability [ 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications

Benhal

Quashie

Kim

et al. 2020

Sensors

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Insulator based dielectrophoresis (iDEP) is becoming increasingly important in emerging biomolecular applications, including particle purification, fractionation, and separation. Compared to conventional electrode-based dielectrophoresis (eDEP) techniques, iDEP has been demonstrated to have a higher degree of selectivity of biological samples while also being less biologically intrusive. Over the past two decades, substantial technological advances have been made, enabling iDEP to be applied from micro, to nano and molecular scales. Soft particles, including cell organelles, viruses, proteins, and nucleic acids, have been manipulated using iDEP, enabling the exploration of subnanometer biological interactions. Recent investigations using this technique have demonstrated a wide range of applications, including biomarker screening, protein folding analysis, and molecular sensing. Here, we review current state-of-art research on iDEP systems and highlight potential future work.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications

Benhal

Quashie

Kim

et al. 2020

Sensors

View full text Add to dashboard Cite

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“…() denotes the time‐averaged volumetric Joule heating in the fluid, and the last term accounts for the surface heat dissipation through the top and bottom walls of the microchannel, where

T_{0}

is the room temperature,

R_{normaltop} = t_{normalPDMS} / k_{normalPDMS} + 1 / h

and

R_{normalbot} = t_{normalglass} / k_{normalglass}

are the equivalent thermal resistances of the top and bottom channel walls with

t_{normalPDMS} false(t_{glass} false)

being the thickness of the top PDMS (bottom glass) wall,

k_{normalPDMS} false(t_{glass} false)

the PDMS (glass) thermal conductivity, and h is the natural convection coefficient from the upper surface of the top wall [46]. Note that the dielectric loss heating in the substrate [47] is neglected in the energy equation because of the small permittivity of the microchannel walls and the low frequency of the applied electric field. Moreover, the lower surface of the glass wall has been assumed to be at thermal equilibrium with the isothermal microscope stage.…”

Section: Simulationmentioning

confidence: 99%

Joule heating‐enabled electrothermal enrichment of nanoparticles in insulator‐based dielectrophoretic microdevices

et al. 2020

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Insulator‐based dielectrophoresis (iDEP) exploits the electric field gradients formed around insulating structures to manipulate particles for diverse microfluidic applications. Compared to the traditional electrode‐based dielectrophoresis, iDEP microdevices have the advantages of easy fabrication, free of water electrolysis, and robust structure, etc. However, the presence of in‐channel insulators may cause thermal effects because of the locally amplified Joule heating of the fluid. The resulting electrothermal flow circulations are exploited in this work to trap and concentrate nanoscale particles (of 100 nm diameter and less) in a ratchet‐based iDEP microdevice. Such Joule heating‐enabled electrothermal enrichment of nanoparticles are found to grow with the increase of alternating current or direct current electric field. It also becomes more effective for larger particles and in a microchannel with symmetric ratchets. Moreover, a depth‐averaged numerical model is developed to understand and simulate the various parametric effects, which is found to predict the experimental observations with a good agreement.

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“…( D) Schematic illustration of a microchip featuring the electrorotation technique for the analysis of ovarian cancer cells (Adapted from [66] by permission of PLoS ONE ). ( E) Device overview for an electrothermal study (Adapted from [67] by permission of Scientific Reports ).…”

Section: Electrokinetic Fundamentalsmentioning

confidence: 99%

A survey of electrokinetically‐driven microfluidics for cancer cells manipulation

et al. 2020

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Cancer is one of the leading causes of annual deaths worldwide, accounting for nearly 10 million deaths each year. Metastasis, the process by which cancer spreads across the patient's body, is the main cause of death in cancer patients. Because the rising trend observed in statistics of new cancer cases and cancer‐related deaths does not allow for an optimistic viewpoint on the future—in relation to this terrible disease—the scientific community has sought methods to enable early detection of cancer and prevent the apparition of metastatic tumors. One such method is known as liquid biopsy, wherein a sample is taken from a bodily fluid and analyzed for the presence of CTCs or other cancer biomarkers (e.g., growth factors). With this objective, interest is growing by year in electrokinetically‐driven microfluidics applied for the concentration, capture, filtration, transportation, and characterization of CTCs. Electrokinetic techniques—electrophoresis, dielectrophoresis, electrorotation, and electrothermal and EOF—have great potential for miniaturization and integration with electronic instrumentation for the development of point‐of‐care devices, which can become a tool for early cancer diagnostics and for the design of personalized therapeutics. In this contribution, we review the state of the art of electrokinetically‐driven microfluidics for cancer cells manipulation.

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Localized Dielectric Loss Heating in Dielectrophoresis Devices

Cited by 26 publications

References 46 publications

Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications

Insulator Based Dielectrophoresis: Micro, Nano, and Molecular Scale Biological Applications

Joule heating‐enabled electrothermal enrichment of nanoparticles in insulator‐based dielectrophoretic microdevices

A survey of electrokinetically‐driven microfluidics for cancer cells manipulation

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