Localized cutaneous argyria

Hristov, Alexandra C.; High, Whitney A.; Golitz, Loren E.

doi:10.1016/j.jaad.2010.05.016

Cited by 22 publications

(19 citation statements)

References 4 publications

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“…[65] Environmental and incidental Localized argyria has occurred due to chemical explosion, [66] and trauma. [67,68] Contaminated water used in hemodialysis has led to generalized argyria. [69] Clinical features In general, the macular pigmentation in argyria is slate -grey.…”

Section: Discussion Discussionmentioning

confidence: 99%

Prevalence and risk factors of onychomycosis in primary school children living in rural and urban areas in Central Anatolia of Turkey

Gülgün¹,

Balcı²,

Karaoğlu³

et al. 2013

Indian J Dermatol Venereol Leprol

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Section: Discussion Discussionmentioning

confidence: 99%

Prevalence and risk factors of onychomycosis in primary school children living in rural and urban areas in Central Anatolia of Turkey

Gülgün¹,

Balcı²,

Karaoğlu³

et al. 2013

Indian J Dermatol Venereol Leprol

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“…[1-4] Silver particles are deposited around adnexal structures in the dermis, classically in the basement membrane of eccrine coils, but they can also be found on the dermal side of the dermal-epidermal junction and around nerves, capillary walls, arrector pilori muscles, and collagen and elastin fibers. [5, 6]…”

Section: Introductionmentioning

confidence: 99%

Quantitative near infrared spectroscopic analysis of Q‐Switched Nd:YAG treatment of generalized argyria

et al. 2013

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Background and Objective Generalized argyria is a blue-gray hyperpigmentation of the skin resulting from ingestion or application of silver compounds, such as silver colloid. Case reports have noted improvement after Q-Switched Neodymium--Yttrium Aluminum Garnet laser (1064nm QS Nd:YAG) laser treatment to small surface areas. No reports have objectively monitored laser treatment of generalized argyria over large areas of skin, nor have long-term outcomes been evaluated. Study Design/Materials and Methods An incremental treatment plan was developed for a subject suffering from argyria. A quantitative near infrared spectroscopic measurement technique was employed to non-invasively analyze tissue-pigment characteristics pre- and post-laser treatment. Post-treatment measurements were collected at weeks 1, 2, 3, and 4, and again at 1 year. Results Immediate apparent removal of pigment was observed with 1 Q-switched 1064 nm Nd:YAG laser treatment (3-6 mm spot; 0.8-2 J/cm2) per area. Entire face, neck, upper chest and arms were treated over multiple sessions. Treatments were very painful and general anesthesia was utilized in order to treat large areas. Near-infrared spectroscopy was used to characterize and quantify the concentration of silver particles in the dermis based on the absorption features of the silver particles as well as the optical scattering effects they impart. We were able to estimate that there was, on average, 0.042 mg/mL concentration of silver prior to treatment and that these levels went below the minimum detectable limit of the instrument post-treatment. There was no recurrence of discoloration over the 1-year study period. Conclusion QS 1064 nm laser treatment of argyria is a viable method to restore normal skin pigmentation with no evidence of recurrence over study period. Quantitative spectroscopic measurements, 1) confirmed dyspigmentation was due to silver, 2) validated our clinical assessment of no recurrence up to one year post-treatment and 3) indicated no collateral tissue damage with treatments.

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“…This condition is generally diagnosed by histopathology, although in certain cases it may be necessary to identify the presence of the metal by electron microscopy. 2,3 In the present case report, we describe a patient who developed localized argyria caused by the implantation of a silver earring in the right ear. Clinically, the presentation was similar to that of a blue nevus.…”

Section: Introductionmentioning

confidence: 87%

“…Localized argyria has been reported as the result of the use of topical medication and the inadvertent implanting in the skin of objects that contain silver. 1,2 Clinically, this type of argyria is characterized by the appearance of blue-gray macules in skin areas near to the objects implanted. This condition is generally diagnosed by histopathology, although in certain cases it may be necessary to identify the presence of the metal by electron microscopy.…”

Section: Introductionmentioning

confidence: 99%

Argyria mimicking a blue nevis: dermoscopy features

Enei¹,

Paschoal²,

Valdés³

2013

An. Bras. Dermatol.

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Argyria is a rare disease caused by prolonged skin contact with silver. Localized cases have been described regarding the use of topical medications, and trauma with objects containing this metal such as acupuncture needles and jewelry. Clinically, a macule or a patch, round or oval, appears in the infected area, with a characteristic bluey-gray color. To our knowledge this is the first time that this clinical condition has been described through the use of dermoscopy.

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Localized cutaneous argyria

Cited by 22 publications

References 4 publications

Prevalence and risk factors of onychomycosis in primary school children living in rural and urban areas in Central Anatolia of Turkey

Prevalence and risk factors of onychomycosis in primary school children living in rural and urban areas in Central Anatolia of Turkey

Quantitative near infrared spectroscopic analysis of Q‐Switched Nd:YAG treatment of generalized argyria

Argyria mimicking a blue nevis: dermoscopy features

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