Localized cervical neuroblastoma: prevention of surgical complications

Haddad, M; Triglia, Jean‐Michel; Helardot, P. G.; Couanet, D.; Gauthier, F.; Neuenschwander, S.; Bourlière, B; Bergeron, Christophe; Munzer, Caroline; Rubie, H; Guys, Jean-Michel

doi:10.1016/j.ijporl.2003.08.046

Cited by 36 publications

(26 citation statements)

References 22 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 Resectable localized tumors can be cured by complete excision, but caution is required because of the risk of complications such as damage to the sympathetic cervical nerves, cranial nerves IX and X, and vascular structures. 2,4,5 For unresectable tumors, especially for emergency cases with airway obstruction, prompt chemotherapy should be initiated after biopsy for accurate diagnosis. Concurrent steroid use might be beneficial to some extent for reduction of edema surrounding tumor.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Children with retropharyngeal NBL often present with progressive dyspnea from airway compression. 2,3 Complete excision is often difficult because of localization near vital vasculature and, when surgery is possible, there is the risk of complications such as swallowing disturbances and Horner syndrome. 2,4,5 We report a 3-month-old boy with retropharyngeal NBL who was successfully treated with chemotherapy alone.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Retropharyngeal Neuroblastoma in an Infant

Matsumura

Ohta²,

Kusuki³

et al. 2010

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Retropharyngeal neuroblastoma is rare. We report a 3-month-old infant with retropharyngeal neuroblastoma presenting with airway compression, which had an unresectable localized tumor without N-myc amplification. He was promptly treated with chemotherapy, resulting in a dramatic resolution. Subsequently, he received no surgical intervention and is well without evidence of recurrence 10 months after completion of chemotherapy. A review of the literature reveals that retropharyngeal neuroblastoma in infants has a good prognosis, but with some risk of surgical complication. Thus, it might be better to treat unresectable, localized disease accompanied by life-threatening symptoms with chemotherapy alone.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Retropharyngeal Neuroblastoma in an Infant

Matsumura

Ohta²,

Kusuki³

et al. 2010

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

“…It occurs more frequently in female patients and in children under the age of 3, with median age of presentation at 18.5 months. 72 The mass may mimic infectious adenitis or a branchial cleft cyst on physical examination. Because neuroblastoma arises from the sympathetic chain, patients can present with Horner syndrome.…”

Section: Primary Cervical Neuroblastomamentioning

confidence: 99%

“…These criteria influenced the surgical resectability of the tumor. 72 On MRI, neuroblastoma generally appears as a circumscribed mass in the poststyloid parapharyngeal space (carotid space), 70 although some investigators have described the mass as arising from the retropharyngeal space laterally. 76,77 The internal carotid artery and internal jugular vein are displaced anteriorly.…”

Section: Primary Cervical Neuroblastomamentioning

confidence: 99%

Imaging Neck Masses in the Neonate and Young Infant

Tranvinh

Yeom

Michael

2015

Seminars in Ultrasound, CT and MRI

View full text Add to dashboard Cite

“…The etiology is not clearly understood; however, both familial genetic predisposition and environmental exposures have been postulated as potential causes [1][2][3]. This solid tumor usually originates in the tissue of the adrenal gland (80%) or in the mediastinum (15%) [4]. The extreme clinical heterogeneity reflects the complexity of genetic and genomic events associated with development and progression of the disease.…”

Section: Introductionmentioning

confidence: 99%

Metastatic neuroblastoma of the mandible: a cytogenetic and molecular genetic study

Manor

Kapelushnik

Joshua

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Neuroblastoma (NB) jaw metastases are rare. Here, we report on cytogenetic and genetic studies on metastatic NB to the mandible. A 7-year-old boy, with an abdominal neuroblastoma, presented with a mass of the left body of the mandible. Cytogenetic analysis of the original tumor and the mandibular lesion biopsies revealed similar heterogenous subclones with 42 ~ 47,XY,+der(1)(q11 → qter),-2,del(7)(q21.1 → qter),-8,-9,-10,-11,del(11)(q13.3 → qter),-13,-14,-15,-17, + 18-18,der(18)(?),+21,+m1,+m2,+m3,+m4,+m5,+m6,+m7[cp25]. The different markers were identified by SKY analysis. Most of the cells carried 3-6 of these translocations: der(1;21), der(2;9;17), der(2;15;18), der(2;15;Y), der(8;10), der(10;17). Molecular examination using Neuroblastoma MLPA kit (MRC-Holland) revealed gain of 1q25, 1q42, 2q33, 2p23, 2p24 (N-myc), and 21q22, and loss of 11q22, 11q23, 17p13, and 17q11. FISH analysis using N-myc probe showed high amplification levels of N-myc. The cytogenetic and molecular genetic work-ups revealed that the mandibular lesion is a metastasis of the original abdominal tumor and not a second primary caused by the aggressive treatment. Clinical parameters such as : patient's age, site of primary tumor and the mandibular metastasis, together with poor prognosis genetic markers explain the patient's short-term survival.

show abstract

Localized cervical neuroblastoma: prevention of surgical complications

Cited by 36 publications

References 22 publications

Retropharyngeal Neuroblastoma in an Infant

Retropharyngeal Neuroblastoma in an Infant

Imaging Neck Masses in the Neonate and Young Infant

Metastatic neuroblastoma of the mandible: a cytogenetic and molecular genetic study

Contact Info

Product

Resources

About