Localized argyria with pseudo-ochronosis

Robinson‐Bostom, Leslie; Pomerantz, David K.; Wilkel, Caroline S.; Mader, Russell D.; Lerner, Lisa H.; Dufresne, Raymond G.; Flotte, Thomas J.

doi:10.1067/mjd.2002.116227

Cited by 36 publications

(60 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Paroxysmal nocturnal haemoglobinuria and ingestion of arsenic or silver were among other responses. Pseudo-ochronosis, which is not an inherited disorder, has been described as a result of argyria 52 and long term use of levodopa, methyldopa, 53 antimalarials, or products containing hydroquinone, phenol, resorcinol, mercury or picric acid. 54 Currently there is no specific and effective treatment for alkaptonuria.…”

Section: Discussionmentioning

confidence: 99%

Alkaptonuric Ochronosis with Aortic Valve and Joint Replacements and Femoral Fracture: A Case Report and Literature Review

Fisher¹,

Davis²

2004

Clinical Medicine & Research

View full text Add to dashboard Cite

Alkaptonuria is a rare autosomal recessive disorder of metabolism caused by deficiency of homogentisic acid oxidase and resulting in accumulation of homogentisic acid in collagenous structures. It is characterized by homogentisic aciduria, bluish-black discoloration of connective tissues (ochronosis) and arthropathy of large joints. Less common manifestations include cardiovascular abnormalities, renal, urethral and prostate calculi. Bone fractures are unusual in ochronosis.In this report, we describe a woman, 69 years of age, with a history of dark urine since childhood and progressive pigmentation of the skin, sclera, and auricular cartilages. She had severe arthropathy requiring total joint replacement in both of her knees and right hip. She also had severe aortic stenosis requiring valve replacement, and asymptomatic nephrolithiasis. She presented with a low trauma fracture of the distal femur despite two years of alendroate therapy.We review the etiology, pathogenesis, clinical presentation, diagnosis and treatment of alkaptonuric ochronosis. Early detection is important for prevention and treatment of multiple systems. Nitisinone, a potent inhibitor of 4-hydroxyphenylpyruvate dioxygenase, dramatically reduces production and urinary excretion of homogentisic acid; however, the long-term efficacy and side effects of such therapy are unknown. Identifying the gene for alkaptonuria offers the potential for a new therapeutic approach (replacement therapy with a recombinant enzyme) in the treatment of alkaptonuric ochronosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Alkaptonuric Ochronosis with Aortic Valve and Joint Replacements and Femoral Fracture: A Case Report and Literature Review

Fisher¹,

Davis²

2004

Clinical Medicine & Research

View full text Add to dashboard Cite

show abstract

“…The superficial calcifications were surrounded by socalled pseudo-ochronotic fibers ( Figure 2B), which have been previously described, 6,7 superimposed on granular deposits similar to her initial (pre-laser) argyria biopsy specimens. Although granular silver deposits were appreciated in her pretreatment biopsy specimens, pseudo-ochronotic fibers were not.…”

mentioning

confidence: 88%

Dystrophic Calcification and Accentuated Localized Argyria After Fractionated Carbon Dioxide Laser Therapy of Hypertrophic Scars

et al. 2014

View full text Add to dashboard Cite

We present 2 unique complications secondary to ultrapulsed, fractionated CO2 laser treatment in a patient previously treated with silver-impregnated dressings: (1) the appearance of pseudo-ochronotic fibers in areas of worsening pigmentation and (2) evidence of dystrophic calcification limited to columns of fractionated laser ablation. Therefore, a history of argyria or treatment with silver-impregnated dressings should be considered before treatment with fractionated CO2 lasers.

show abstract

“…Localized argyria may also present with ochre-colored, swollen, and homogenized collagen bundles resembling those seen in ochronosis. 252 There is usually an increase in melanin pigment in the basal layer of the epidermis, and melanophages are present in the papillary dermis.…”

Section: Heavy Metals Silver Deposition (Argyria)mentioning

confidence: 99%

Cutaneous Deposits

Molina-Ruiz

Cerroni

Kutzner

et al. 2014

The American Journal of Dermatopathology

View full text Add to dashboard Cite

: The cutaneous deposition disorders are a group of unrelated conditions characterized by the accumulation of either endogenous or exogenous substances within the skin. These cutaneous deposits are substances that are not normal constituents of the skin and are laid down usually in the dermis, but also in the subcutis, in a variety of different circumstances. There are 5 broad categories of cutaneous deposits. The first group includes calcium salts, bone, and cartilage. The second category includes the hyaline deposits that may be seen in the dermis in several metabolic disorders, such as amyloidosis, gout, porphyria, and lipoid proteinosis. The third category includes various pigments, heavy metals, and complex drug pigments. The fourth category, cutaneous implants, includes substances that are inserted into the skin for cosmetic purposes. The fifth category includes miscellaneous substances, such as oxalate crystals and fiberglass. In this article, the authors review the clinicopathologic characteristics of cutaneous deposition diseases, classify the different types of cutaneous deposits, and identify all the histopathologic features that may assist in diagnosing the origin of a cutaneous deposit.

show abstract

Localized argyria with pseudo-ochronosis

Cited by 36 publications

References 11 publications

Alkaptonuric Ochronosis with Aortic Valve and Joint Replacements and Femoral Fracture: A Case Report and Literature Review

Alkaptonuric Ochronosis with Aortic Valve and Joint Replacements and Femoral Fracture: A Case Report and Literature Review

Dystrophic Calcification and Accentuated Localized Argyria After Fractionated Carbon Dioxide Laser Therapy of Hypertrophic Scars

Cutaneous Deposits

Contact Info

Product

Resources

About