Dystrophic Calcification and Accentuated Localized Argyria After Fractionated Carbon Dioxide Laser Therapy of Hypertrophic Scars

Shaub, Amanda R.; Brown, Patrick J.; Kobayashi, Todd T.; Lewin-Smith, Michael R.; Lupton, George P.; Hivnor, Chad

doi:10.1001/jamadermatol.2013.8044

Cited by 6 publications

(9 citation statements)

References 13 publications

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“…A teenage girl had toxic epidermal necrolysis involving almost 100% of the body surface. She was treated with nanocrystalline silver dressing for an unspecified period, and 4 years later, localized argyria was observed (Shaub et al, 2014). A 50-year-old silversmith had approximately 70 blue macules scattered on his face, limbs, and trunk.…”

Section: Localized Argyriamentioning

confidence: 99%

Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review

Hadrup

Sharma

Loeschner

2018

Regulatory Toxicology and Pharmacology

242

178

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Silver is used in different applications that result in contact with skin and mucosal surfaces (e.g., jewelry, wound dressings, or eye drops). Intact skin poses an effective barrier against the absorption of silver. Mucosal surfaces are observed to be less effective barriers and compromised skin is often a poor barrier. Silver can deposit as particles in the human body causing a blue-gray discoloration known as argyria. Urine and feces are reported pathways of excretion. Acute human mortality has been observed following an abortion procedure involving the intrauterine administration of 7 g silver nitrate (64 mg silver/kg body weight). Localized argyria has been reported with exposure to silver ions, metallic surfaces, and nanocrystalline silver. Generalized argyria was observed with ionic and nanocrystalline silver in humans at cumulative doses in the range of 70-1500 mg silver/kg body weight. Silver is observed to have a low potential for skin irritation. Eye irritation and some cases of allergic contact dermatitis have been reported. Silver may cause genotoxicity, but additional data are required to assess its carcinogenic potential. Other reported toxicities include hepatic, renal, neurological, and hematological effects.

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Section: Localized Argyriamentioning

confidence: 99%

Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review

Hadrup

Sharma

Loeschner

2018

Regulatory Toxicology and Pharmacology

242

178

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“…5 Thus, it is possible that the calcinosis had no relationship to the overlying cutaneous SCC and was the result of tissue damage from previous laser procedures or surgeries. The amount of inflammation observed in this case was unusual for a cutaneous SCC and may have contributed to the formation of the calcinosis.…”

Section: Discussionmentioning

confidence: 99%

Calcinospherules

Davis

Bennett²

2016

The American Journal of Dermatopathology

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Dystrophic calcification may occur in association with cutaneous neoplasms. We report the case of a 50-year-old woman with unusual appearing dystrophic calcification that was mistaken for coccidiomycosis during Mohs micrographic surgery for an invasive squamous cell carcinoma on the lower lip. The term "calcinospherule" is suggested as a term to describe the round calcified bodies found within the lesion that mimicked spherules with endospores characteristic of Coccidioides imitis infection. Both the dermatopathologist and Mohs micrographic surgeon should be aware of this entity as well as other calcified bodies that may be encountered in Mohs micrographic surgery frozen sections. Literature regarding these calcified bodies is briefly reviewed.

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“…[3,4] Prolonging the treatment cycle can lead to poor patient compliance, in parallel to a potential risk of adverse reactions. [5][6][7] Pathological scars are the consequence of aberrant and prolonged inflammation of the reticular dermis following injury. Therefore, the main goal of HS treatment should be the inhibition of excessive inflammation throughout the healing process.…”

Section: Introductionmentioning

confidence: 99%

Early Application of Quaternized Chitin Derivatives Inhibits Hypertrophic Scar Formation

Chen

Xie

Xia

et al. 2021

Macromolecular Bioscience

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Various treatments for hypertrophic scars (HS) are applied after wound re-epithelialization. However, the lack of early intervention within the wound bed leads to poor HS treatment outcomes. In this study, quaternized chitin (QC) derivatives with different degrees of deacetylation (7.4% and 78.9%) are synthesized and their effects on HS formation are evaluated in a rabbit ear scar model. Early application of QC alleviates scar hypertrophy without delayed wound healing. Fibroblast count, collagen content, and 𝜶-smooth muscle actin expression are decreased, while matrix metalloproteinase-1 is upregulated on day 35 in the QC treatment group. QC suppresses inflammatory cell infiltration and IL-6 expression. A subsequent reduction in transforming growth factor 𝜷1 expression is also observed. The inhibitory effect of QC on HS formation is eliminated through the administration of exogenous IL-6. Taken together, early application of QC inhibits HS formation by downregulating IL-6 expression, and QC with a low degree of deacetylation tends to be more effective. Considering its potential for accelerating wound healing, inhibiting HS formation, and its antibacterial activity, QC may be used as an effective dressing in clinical wound management.

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Dystrophic Calcification and Accentuated Localized Argyria After Fractionated Carbon Dioxide Laser Therapy of Hypertrophic Scars

Cited by 6 publications

References 13 publications

Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review

Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review

Calcinospherules

Early Application of Quaternized Chitin Derivatives Inhibits Hypertrophic Scar Formation

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