Localized amyloidosis of the nasal and paranasal mucosa: a rare pathology

Pearlman, Amy; Jeffe, Jill S.; Zynger, Debra L.; Yeldandi, Anjana V.; Conley, David B.

doi:10.1016/j.amjoto.2008.11.003

Cited by 10 publications

(20 citation statements)

References 4 publications

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“…Review of literature from 1928 to date have documented only 38 cases of amyloidosis involving nasal mucosa out of which five cases were of systemic amyloidosis [10]. About 23 cases of isolated sinonasal amyloidosis have been reported on review of the literature [6] of which only 15 cases were true idiopathic isolated amyloidosis [11]. Up to 1935, there were only seven reported cases of sinonasal amyloidosis [12].…”

Section: Discussionmentioning

confidence: 99%

“…Facial pain associated with bony erosion is a worrying feature [5]. Meticulous surgery produces substantial symptomatic improvement in these patients [11]. Systemic amyloidosis should be ruled out by a detailed clinical examination and investigations such as peripheral blood smear, liver function tests, serum electrophoresis, radiographic imaging, electrocardiography and bone marrow biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Systemic amyloidosis should be ruled out by a detailed clinical examination and investigations such as peripheral blood smear, liver function tests, serum electrophoresis, radiographic imaging, electrocardiography and bone marrow biopsy. Abdominal fat aspiration is as sensitive as rectal mucosal biopsy (75-90 %) to rule out systemic amyloidosis [11]. Amyloidosis is characterized ultrastructurally as nonbranching fibrils highly organized in antiparallel b-pleated sheet conformation.…”

Section: Discussionmentioning

confidence: 99%

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Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation

Kumar

Pant

Kumar

et al. 2016

Head and Neck Pathol

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Primary localized amyloidosis in the head and neck region is a rare entity. The most commonly involved organ is larynx. Primary amyloidosis localized to the sinonasal tract is extremely rare. We report one such case along with a brief review of the associated literature. The aim of reporting this case is to emphasize the fact that sometimes nasal amyloidosis can also present with signs and symptoms of nasal and nasopharyngeal malignancy. The definitive diagnosis in such cases depends upon histopathology and further confirmed by immunohistochemistry. A 55-year old male presented with recurrent episodes of nasal bleed, bilateral nasal obstruction, and bilateral hearing loss from last 7 years. On clinical examination a mass was found in the nasal cavity on both sides reaching up to the nasopharynx. Contrast enhanced CT scan revealed that the mass was extending up to the skull base and destroying bony landmarks of the nasal cavity and paranasal sinuses. Mass was proved to be amyloidosis after histopathological examination. It showed multiple blotches of globular submucosal deposit of amyloid, on staining with Congo red. Immunohistochemistry confirmed AL amyloidosis with expression of mixed kappa and lambda light chain immunoglobulin (j [ k). No evidence of systemic amyloidosis was found after proper work up. It was managed by conservative surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation

Kumar

Pant

Kumar

et al. 2016

Head and Neck Pathol

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“…Chin et al reported a case of localized amyloidosis involving simultaneously the sinonasal cavities and the larynx (Chin SC, 2004). Localized amyloidosis of the nasal mucosa is extremely rare with few cases reported in the English literature (Pearlman AN, 2010). Localized amyloidosis of the palate is extremely rare and only five cases have been reported (Aono J, 2009).…”

Section: Localizationmentioning

confidence: 99%

“…Radiotherapy may be a treatment option in nasal and nasopharyngeal amyloidosis. Symptoms may be improved with steroid treatment (Pearlman AN, 2010).…”

Section: Sinonasal Cavities and Nasopharynxmentioning

confidence: 99%

Localized ENT Amyloidosis – Literature Overview

Hammami¹,

Mnejja²,

Sellami³

et al. 2011

Amyloidosis - An Insight to Disease of Systems and Novel Therapies

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Amyloidosis of the Nasopharynx and Nasal Cavity Presenting as Severe Epistaxis and Sphenoid Sinus Dehiscence

Harirchian¹,

Mirani²,

Baredes³

2011

The Laryngoscope

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Amyloidosis is a collection of diseases characterized by the extracellular deposition of the insoluble fibrillar proteinaceous material, amyloid. Its symptoms vary depending on whether the pathology is systemic or localized, and on the organ systems involved. While localized amyloidosis is rare, constituting 10-20% of amyloidosis cases, it most commonly affects the head and neck. 1,2 The larynx is most frequently affected, followed by the orbit, salivary glands, oral cavity and oropharynx. 3 Nasopharyngeal and nasal cavity amyloidosis is extremely rare, with only 14 prior case reports in the literature. [3][4][5] Presenting symptoms typically include epistaxis, nasal obstruction, and otologic findings due to Eustachian tube obstruction. CT findings are nonspecific, typically revealing a non or minimally enhancing soft tissue mass with areas of calcification and no bony erosion. [6][7][8] It is typically treated with surgical resection and carries an excellent prognosis, despite recurrences. We present a patient with localized amyloidosis of the nasal cavity and nasopharynx who presented with severe epistaxis and sphenoid sinus dehiscence, and eventually had spontaneous amyloidoma resolution with conservative management. We will review the clinical and radiographic features of localized nasopharyngeal and nasal cavity amyloidosis, as well as its management and a review of the literature. Our case highlights the possibility that nasopharyngeal amyloidosis may be managed conservatively with spontaneous regression.

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Localized amyloidosis of the nasal and paranasal mucosa: a rare pathology

Cited by 10 publications

References 4 publications

Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation

Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation

Localized ENT Amyloidosis – Literature Overview

Amyloidosis of the Nasopharynx and Nasal Cavity Presenting as Severe Epistaxis and Sphenoid Sinus Dehiscence

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