Localized ENT Amyloidosis – Literature Overview

Hammami, B.; Mnejja, Malek; Sellami, M.; Taieb, Hanene Hadj; Chakroun, A.; Charfeddine, Ilhem; Ghorbel, Abdelmonem

doi:10.5772/23673

Cited by 2 publications

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Localized amyloidosis can be found anywhere within the body 5 with the larynx one of the more common locations (14%–15%). Bladder and cutaneous tissue are also frequent sites of involvement 6–8 . When amyloid is localized in the larynx, it is usually the AL type, where the fibril precursor protein is either kappa or lambda light chains, derived from monoclonal immunoglobulins 7 .…”

Section: Introductionmentioning

confidence: 99%

One Hundred Cases of Localized Laryngeal Amyloidosis ‐ Evidence for Future Management

et al. 2021

View full text Add to dashboard Cite

Objective/Hypothesis: To update the current understanding of localized laryngeal amyloidosis by analyzing the NHS National Amyloidosis Database and to further clarify the important ongoing management issues.Study Design: Retrospective review, case series. Methods: Patients with laryngeal amyloid were identified from the database of the NHS National Amyloidosis Center, UCL, Royal Free Hospital, London between 2000 and 2017. Patient demographics and disease profile were collated, including the exact location of amyloid deposit, treatments if any, and progression of disease.Results: One hundred and three patients with localized laryngeal amyloid where identified from the database, with a mean age of 54 at diagnosis and female to male ratio of 54:49. Three patients were excluded from further analysis due to limited database information. The majority of amyloid was found in either the supraglottis (44) or glottis (53) but all the laryngeal subsites were involved. One-third of the patients (34) had amyloid in more than one laryngeal subsite. No patients were found to progress to systemic amyloid, but many progressed locally to other subsites or further down the LTB tree (29%). Three patients were successfully treated with radiotherapy after other modalities had failed.Conclusions: This is the largest case series reported to date of localized laryngeal amyloidosis. It highlights the high incidence of multifocal disease and the significant proportion of patients who progressed, not to systemic amyloidosis but to more extensive localized amyloid. We recommend that in all cases of laryngeal amyloid, patients should undergo a thorough assessment of the upper and lower airways and have ongoing surveillance for at least 15 years.

show abstract

Section: Introductionmentioning

confidence: 99%

One Hundred Cases of Localized Laryngeal Amyloidosis ‐ Evidence for Future Management

et al. 2021

View full text Add to dashboard Cite

show abstract

A case of localized nodular amyloidosis in the sublingual gland and submucosa of the mouth floor

Hara

Ishihama

Togawa

et al. 2021

Jpn. J. Oral. Maxillofac. Surg.

View full text Add to dashboard Cite

Amyloidosis is a rare disease characterized by the deposition of an insoluble fibrillar protein in various organs and classified into two categories: systemic and localized. In the oral and maxillofacial region, the occurrence sites of localized amyloidosis are the buccal mucosa, sublingual gland, lip, palate and tongue. We report a case of localized nodular amyloidosis in the sublingual gland and submucosa of the mouth floor. A 72-year-old woman presented a nodular mass in the left side of the floor of her mouth and was referred to our hospital for further examination and treatment. Intraoral examination showed an elastic-hard, wellcircumscribed mass, covered with normal epithelium, measuring approximately 32 × 15 mm in size. The pathological diagnosis via biopsy was amyloidosis (AL amyloidosis of the Aλ type) . We diagnosed localized amyloidosis, as examination data did not support a diagnosis of systemic amyloidosis and multiple myeloma. The mass was removed surgically under general anesthesia. Seventeen months have since passed, with no sign of recurrence. Key words: localized nodular amyloidosis (限局性結節性アミロイドーシス) ， sublingual gland (舌下腺) ， floor of the mouth (口底) 1) 大阪大学大学院歯学研究科顎口腔疾患制御学講座 (口腔外科第一教室) (主任：田中晋教授)2) 大阪警察病院歯科口腔外科 (主任：石濱孝二部長)

show abstract

Localized ENT Amyloidosis – Literature Overview

Cited by 2 publications

References 64 publications

One Hundred Cases of Localized Laryngeal Amyloidosis ‐ Evidence for Future Management

One Hundred Cases of Localized Laryngeal Amyloidosis ‐ Evidence for Future Management

A case of localized nodular amyloidosis in the sublingual gland and submucosa of the mouth floor

Contact Info

Product

Resources

About