Localized air-mediated heating method for isothermal and rapid thermal processing on lab-on-a-disk platforms

Pishbin, Esmail; Eghbal, Mohammad Hossein; Navidbakhsh, Mahdi; Zandi, Mohammad

doi:10.1016/j.snb.2019.05.039

Cited by 11 publications

(7 citation statements)

References 41 publications

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“…However, most of them require external actuation by an instrument-based module. Examples are wax plugs 71 – 73 , 78 and barrier films that are disrupted by knife cutters (xurography) 69 , pressure sources, heat 71 , 77 , 107 , ice 108 , or (laser) irradiation 74 . Such flow barriers may be trivially included in the pressure equilibrium ( 9 ) by a counter pressure jumping to infinity when the liquid arrives at the sacrificial material.…”

Section: Basic Centrifugal Flow Control Schemesmentioning

confidence: 99%

Systematic review of centrifugal valving based on digital twin modeling towards highly integrated lab-on-a-disc systems

Ducrée

2021

Microsyst Nanoeng

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Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control which mainly depend on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates efficient simulation tools for virtual prototyping and characterization and algorithmic design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, layout, fluidic testing, bioanalytical validation, and scale-up to commercial mass manufacture.

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Section: Basic Centrifugal Flow Control Schemesmentioning

confidence: 99%

Systematic review of centrifugal valving based on digital twin modeling towards highly integrated lab-on-a-disc systems

Ducrée

2021

Microsyst Nanoeng

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“…However, most of them require external actuation by an instrument-based module. Examples are wax plugs [73][74][75]80] melted by irradiation and barrier films that are disrupted by knife cutters (xurography) [71], pressure sources, heat [73,79,108], ice [109] or laser ablation [76]. Such flow barriers may be trivially included in the pressure equilibrium ( 9) by a counter pressure jumping to infinity when the liquid arrives at the sacrificial material.…”

Section: Basic Centrifugal Flow Control Schemes Sacrificial Barriersmentioning

confidence: 99%

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Ducrée¹

2021

Preprint

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Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control mainly based on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates the provision of efficient simulation tools for virtual prototyping and characterization to greatly expedite design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, fluidic testing, bioanalytical validation and scale-up to commercial mass manufacture.

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“…This is useful in applications that require adjustment of the residence time such as thermally dependent reactions, e.g., PCR for DNA amplification by implementing the presented heating methods for centrifugal microfluidics. 25 An adjacent stream of the gas phase to the liquid phase can be used for removing the bubbles generated in the liquid passing the hightemperature zones.…”

Section: Analytical Modelmentioning

confidence: 99%

Frequency dependent multiphase flows on centrifugal microfluidics

et al. 2020

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Localized air-mediated heating method for isothermal and rapid thermal processing on lab-on-a-disk platforms

Cited by 11 publications

References 41 publications

Systematic review of centrifugal valving based on digital twin modeling towards highly integrated lab-on-a-disc systems

Systematic review of centrifugal valving based on digital twin modeling towards highly integrated lab-on-a-disc systems

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Frequency dependent multiphase flows on centrifugal microfluidics

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