Localization on pig chromosome 6 of five markers: GPI, APOE, TGFβ 1, ENO1 and PGD, carried by human chromosomes 1 and 19, using in situ hybridization

The TGF beta-1 and PGD loci have been localized by in situ hybridization to the C-greater than q2.1 and q2.2 -greater than q2.5 regions of pig chromosome 6. These assignments confirm that the conversation of syntenic groups around GPI and PGD extends to pigs where these two groups are uniquely found to be linked. Our data also support the hypothesis that the porcine and human inherited malignant hyperthermia syndromes are caused by mutations in homologous genes which map to human chromosome 19q, porcine chromosome 6q and murine chromosome 7.

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First International Workshop on Porcine Chromosome 6

Paszek

Schook

Louis

et al. 1995

Animal Genetics

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Summary Recent advances in the use of microsatellite markers and the development of comparative gene mapping techniques have made the construction of high resolution genetic maps of livestock species possible. Framework and comprehensive genetic linkage maps of porcine chromosome 6 have resulted from the first international effort to integrate genetic maps from multiple laboratories. Eleven highly polymorphic genetic markers were exchanged and mapped by four independent laboratories on a total of 583 animals derived from four reference populations. The chromosome 6 framework map consists of 10 markers ordered with high local support. The average marker interval of the framework map is 15.1 cM (sex averaged). The framework map is 135, 175 and 109 cM in length (for sex averaged, female and male maps, respectively). The comprehensive map includes a total of 48 type I and type II markers with a sex averaged interval of 3.5 cM and is 166, 196 and 126 cM (for sex averaged, female and male maps, respectively). Additional markers within framework map marker intervals can thus be selected from the comprehensive map for further analysis of quantitive trait loci (QTL) located on chromosome 6. The resulting maps of swine chromosome 6 provide a valuable tool for analysing and locating QTL.

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Localization on pig chromosome 6 of five markers: GPI, APOE, TGFβ 1, ENO1 and PGD, carried by human chromosomes 1 and 19, using in situ hybridization

Cited by 3 publications

References 3 publications

Linkage of LHB and MAG to GPI on sheep Chromosome 14

Linkage of LHB and MAG to GPI on sheep Chromosome 14

Localization of the PGD and TGFβ‐1 loci to pig chromosome 6q

First International Workshop on Porcine Chromosome 6

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