Localization of tolerogenic epitopes in the α1 helical region of the rat class I major histocompatibility complex molecule

Stepkowski, S. M.; Wang, M.; Langowski, John L.; Ghobrial, Rafik; Qu, Xiumei; Yu, Jian; Tian, Ling; Kahan, Barry D.

doi:10.1016/s0041-1345(97)00006-7

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Extra-thymic Inoculation Of Allopeptides1

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2007

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Cited by 2 publications

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“…For example, they produced an allochimeric protein (α1H u70-77-RT1.Aa) by superimposing the nucleotides encoding last four (His70, Val73, Asn74, and Asn77) of nine (Arg62, Glu63, Gln65, Gly66, Gly69, His70, Val73, Asn74, and Asn77) polymorphic amino acids in the α1helical region of donor-type RT1.Au onto the host RT1.Aa backbone using gene splicing and overlap extension. Intraportal injection of this allochimeric protein significantly prolonged the survival of Wistar-Furth (WF, RT1u) cardiac allografts in ACI (RT1a) rats (111,112). They have further used allochimeric proteins via the oral route to induce allo-specific tolerance (113).…”

Section: Extra-thymic Inoculation Of Allopeptidesmentioning

confidence: 99%

Allopeptides and the alloimmune response

Bharat

Mohanakumar

2007

Cellular Immunology

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The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells. The nature of allopeptides presented along with tolerogenic strategies like altered peptide ligands and intra- or extra-thymic allopeptide inoculation are discussed. In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses.

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Section: Extra-thymic Inoculation Of Allopeptidesmentioning

confidence: 99%