Localization of the ?2-macroglobulin gene and Lpm gene family on mink chromosome 9

Yermolaev, V. I.; Karasik, G. I.; Khlebodarova, T. M.; Matveeva, N. M.; Mullakandov, M. R.; Nayakschin, A. M.; Shumny, T. V.; Rubtsov, N. B.; Serov, O. L.; Baranov, O. K.

doi:10.1007/bf00299760

Cited by 5 publications

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“…Polymorphic Lpm genes are associated with the behavioral genes located in the same chromo some. Earlier, we found that the Lpm locus is localized in mink chromosome 9, which is homologous to human chromosome 12 (Yermolaev et al, 1989), the gene structure of which is known and sufficiently sim ilar in many mammalian species, including pigs (Yermolaev et al, 2013). It can be assumed that, in mink, this set does not differ significantly from humans.…”

Section: Discussionmentioning

confidence: 91%

Selection for behavior and correlation with the macroglobuline and lypoproteine systems in the American mink (Neovison vison)

Yermolaev

Savina

Yudin

et al. 2014

Russ J Genet Appl Res

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A population genetic comparison between mink populations with tame and aggressive behavior was performed. Six allotypes of the Lpm system, the AIM alpha macroglobulin, and two allotypes of the Ld system, a homologue of APOB low density lipoprotein, were analyzed. The pairwise compared groups dif fered in markers Lpml, Lpm3, Lpm5, and Lpm10. Alleles with allotypes Lpml and Lpm3 were significantly associated with aggressive behavior, whereas allele Lpm non 10 was associated tame behavior. No statistically significant differences in the frequencies of Ldl and Ld2 allotypes of the Ld low density lipoprotein system have been found.Keywords: American mink, Neovison vison, polymorphism in the Lpm = AM family, Ld = APOB, allotypes, tame and aggressive behavior

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Section: Discussionmentioning

confidence: 91%

Selection for behavior and correlation with the macroglobuline and lypoproteine systems in the American mink (Neovison vison)

Yermolaev

Savina

Yudin

et al. 2014

Russ J Genet Appl Res

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“…No intraspecific polymorphism for the second α‐macroglobulin (AM) variant known as α 2 M and under the control of presumably unique genes, has been found (Y ermolaev et al 1988). There is reason for considering mink Lpm (α,M) and α 2 M and their genes as members of the same family of homologoes: similarities of the main structural features of mink Lpm and α 2 M, and also location of their controlling genes on the same chromosome 9 (Y ermolaev et al 1989). Furthermore, as may by judged by intra‐ and interspecific variability of antigenic structure, Lpm appears to be the evolutionary most unstable member of the alpha‐macroglobulin family, while α 2 M seems to be its evolutionary conserved member (Y ermolaev et al 1988; S humny et al 1989).…”

Section: Introductionmentioning

confidence: 99%

A comparative study of the homologous Lpm‐system allotypes of alpha‐macroglobulins in American mink and Gp‐system allotypes of alpha‐macroglobulin in domestic pig

Yermolaev

Mirtskhoulava

Savina

et al. 1992

J Animal Breeding Genetics

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Summary This paper summarizes our results with allotyping of alpha‐macroglobulins in pig and the comparative results with their homologs in mink. In p.g, 5 allotypes of α‐macroglobulins, αM1, αM2, αM3AB, αM4, and αM5ab were identified. It was found that αM1, a marker of α‐macroglobulin in pig, is homologous to human α2‐macroglobulin and mink α2‐macroglobulin; αM2‐αM5, the markers of the second isotypic variant of α‐macroglobulin in pig, are homologous to mink Lpm‐macroglobulin (α1M). The results of the International comparison test (ISABR, 1987–1988) have demonstrated αM1 is new and αM2‐αM5 correspond to the four allotypes of the Gp‐system in pig (Janik et al. 1983). It is concluded that the pig Gp and mink Lpm systems are homologous. Because the studied allotypes belong to α‐macroglobulins, their controlling locus is designated as the AM‐locus. The same designation is suggested for the homologous mink locus (instead of the previous Lpm). The genetic control of 5 allotypes of pig is analysed. The structure of the pig AM‐locus is described in detail, and its organization is compared with the mink homologous locus. Zusammenfassung Vergleichende Untersuchung von α‐Makroglobulin Allotypen des Lpm Systems beim Nerz und des Gp‐Systems beim Hausschwein Diese Veröffentlichung faßt unsere Ergebnisse bezüglich der Allotypen von α‐Makroglobulin des Schweines und die vergleichenden Ergebnisse ihrer Homologe beim Nerz zusammen. Beim Schwein wurden 5 Allotypen des α‐Makroglobulins (αM1, αM2, αM3, αM4 und αM5) identifiziert. Das αM1, ein Marker des α‐Makroglobulins des Schweines, ist homolog zu dem menschlichen α2‐Makroglobulin und dem α2‐Makroglobulin des Nerzes; αM2−αM5, Marker der zweiten isotopischen Variante des α‐Makroglobulin, sind dem Nerz Lpm‐Macroglobulin (α1M) homolog. Die Ergebnisse des Internationalen Vergleichstestes (ISABR, 1987–1988) hatten demonstriert, daß αM1 neu ist, und daß αM2−αM5 mit den vier Allotypen des Gp‐Systems vergleichbar sind (Janik et al. 1983). Es wird daraus geschlossen, daß Schweine Gp und Nerz Lpm‐System homolog ist. Da die untersuchten Allotypen dem α‐Makroglobulin angehören, wird ihr kontrollierender Locus AM‐Locus genannt. Die gleiche Benennung (statt der vorigen Lpm) wird für den homologen Nerz Locus vorgeschlagen. Die genetische Steuerung der 5 Allotypen des Schweines sind damit auch analysiert, die Struktur des Schweine AM‐Locus beschrieben, und seine Organisation ist mit der homologen des Nerz‐Locus verglichen.

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Characterization of a new hybrid mink-mouse clone panel: chromosomal and regional assignments of the GLO, ACY, NP, CKBB, ADH2, and ME1 loci in mink (Mustela vison)

et al. 1992

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To expand the mink map, we established a new panel consisting of 23 mink-mouse clones. On the basis of statistical criteria (Wijnen et al. 1977; Burgerhout 1978), we developed a computer program for choice of clones of the panel. Assignments of the following mink genes were achieved with the use of the hybrid panel: glyoxalase (GLO), Chromosome (Chr) 1; acetyl acylase (ACY), Chr 5; creatine phosphokinase B (CKBB), Chr 10; alcohol dehydrogenase-2 (subunit B) (ADH2), Chr 8. Using a series of clones carrying rearrangements involving mink Chr 1 and 8, we assigned the gene for ME1 to the short arm of Chr 1 and that for ADH2 to Chr 8, in the region 8p12-p24. Mapping results confirm the ones we previously obtained with a mink-Chinese hamster panel. However, by means of an improved electrophoretic technique, we revised the localization of the gene for purine nucleoside phosphorylase (NP), which has been thought to be on mink Chr 2. It is reassigned to mink Chr 10.

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Localization of the ?2-macroglobulin gene and Lpm gene family on mink chromosome 9

Cited by 5 publications

References 14 publications

Selection for behavior and correlation with the macroglobuline and lypoproteine systems in the American mink (Neovison vison)

Selection for behavior and correlation with the macroglobuline and lypoproteine systems in the American mink (Neovison vison)

A comparative study of the homologous Lpm‐system allotypes of alpha‐macroglobulins in American mink and Gp‐system allotypes of alpha‐macroglobulin in domestic pig

Characterization of a new hybrid mink-mouse clone panel: chromosomal and regional assignments of the GLO, ACY, NP, CKBB, ADH2, and ME1 loci in mink (Mustela vison)

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