Localization of oncofetal and normal fibronectin in colorectal cancer. Correlation with histologic grade, liver metastasis, and prognosis

Inufusa, Haruhiko; Nakamura, Masato; Adachi, Toshiyuki; Nakatani, Yoshihiro; Shindo, Katsuhisa; Yasutomi, Masayuki; Matsuura, Hidemitsu

doi:10.1002/1097-0142(19950615)75:12<2802::aid-cncr2820751204>3.0.co;2-o

Cited by 56 publications

(37 citation statements)

References 30 publications

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“…Expression of oncofetal (but not normal) fibronectin correlated with advanced stage and poor survival in colorectal carcinoma. 11 Similar findings were not reported for C IV.…”

supporting

confidence: 71%

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Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study.

et al. 1998

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Aim-To evaluate the intracellular and peritumoral expression of matrix proteins in squamous cell carcinoma of the uterine cervix using immunohistochemistry. Methods-71 squamous cell carcinomas and 10 controls were stained for laminin, fibronectin, and collagen IV. Cytoplasmic staining in tumour cells and peritumoral deposition of matrix proteins were evaluated. The association between staining results and patient age, tumour stage, histological grade, and survival was studied. Results-Positive cytoplasmic staining for laminin, fibronectin, and collagen IV was observed in 17 (23.9%), 27 (38%), and 10 (14.1%) cases, respectively. Staining for laminin was most pronounced in the invasive front of tumour islands, while for fibronectin and collagen IV it appeared to be diVuse. Peritumoral staining for laminin and collagen IV was detected in 12 cases (16.9%). Early stage (Ia1-Ia2) tumours were uniformly negative for all three proteins. Cytoplasmic staining for laminin correlated with positive staining for fibronectin and collagen IV, and with the presence of a peritumoral deposition of collagen IV and laminin. There was no correlation with any of the three markers between staining results and patient age, stage, grade, or survival. Conclusions-Expression of extracellular matrix proteins in some cervical squamous cell carcinomas might reflect the enhanced ability of these tumours to modify the peritumoral stroma. This ability seems to be absent in early stage tumours. The correlation between intracytoplasmic and peritumoral expression of matrix proteins supports the evidence of their synthesis by tumour cells. However, this property did not correlate with disease outcome in this study. (J Clin Pathol 1998;51:781-785)

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“…Expression of oncofetal (but not normal) fibronectin correlated with advanced stage and poor survival in colorectal carcinoma. 11 Similar findings were not reported for C IV.…”

supporting

confidence: 71%

“…Fibronectins, a family of high molecular weight adhesive glycoproteins, have been demonstrated immunohistochemically in breast 10 and colorectal 11 cancer cells. Laminins consist of a family of nine high molecular weight glycoproteins composed of varying , , and chains.…”

mentioning

confidence: 99%

Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study.

et al. 1998

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“…Lung cancer Nakashima et al (92) Urothelial tumor Lascombe et al (93) Fibronectin High-molecular weight extracellular matrix glycoprotein Bladder tumor Mutlu et al (94) Colorectal cancer Inufusa et al (95) Ovarian carcinoma Franke et al (96) Transcription factor Snail Zinc finger transcriptional repressor Adenocortical carcinoma Waldmann et al (97) Esophageal cancer Natsugoe et al (98) Hepatocellular carcinoma Miyoshi et al …”

Section: Microenvironment and Emtmentioning

confidence: 99%

Epithelial–mesenchymal transition in cancer development and its clinical significance

et al. 2010

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The epithelial-mesenchymal transition (EMT) plays a critical role in embryonic development. EMT is also involved in cancer progression and metastasis and it is probable that a common molecular mechanism is shared by these processes. Cancer cells undergoing EMT can acquire invasive properties and enter the surrounding stroma, resulting in the creation of a favorable microenvironment for cancer progression and metastasis. Furthermore, the acquisition of EMT features has been associated with chemoresistance which could give rise to recurrence and metastasis after standard chemotherapeutic treatment. Thus, EMT could be closely involved in carcinogenesis, invasion, metastasis, recurrence, and chemoresistance. Research into EMT and its role in cancer pathogenesis has progressed rapidly and it is now hypothesized that novel concepts such as cancer stem cells and microRNA could be involved in EMT. However, the involvement of EMT varies greatly among cancer types, and much remains to be learned. In this review, we present recent findings regarding the involvement of EMT in cancer progression and metastasis and provide a perspective from clinical and translational viewpoints. (Cancer Sci 2010; 101: 293-299) D evelopment of distant metastases is the final stage of solid cancer progression and is responsible for the majority of cancer-related deaths.(1) Distant metastasis alone or with concurrent locoregional recurrence accounts for nearly 80% of all first relapses in women with breast cancer.(2) While clinically of great importance, the biology of metastasis remains unsolved. The process of tumor metastasis consists of multiple steps, all of which are required to achieve tumor spreading.(3,4) First, cancer cells escape from the primary tumor site. Next, cancer cells invade the tumor stroma and enter the blood circulation directly or the lymphatic system via intravasation. Most circulating cancer cells undergo apoptosis due to anoikis conditions.(5) If cancer cells survive in circulation they may reach more suitable sites by attaching to endothelial cells and extravasating from the circulation into the surrounding tissues. Finally, distal colonization requires that cancer cells invade and grow in the new environment.Recently, the concept of the epithelial-mesenchymal transition (EMT), as developed in the field of embryology, has been extended to cancer progression and metastasis.(6,7) In vitro and experimental animal model data now support the role of EMT in metastasis, concepts supported by analyses of clinical samples. Indeed, the biology of EMT has been clarified in tumor samples through use of EMT-associated markers, such as mesenchymalspecific markers (i.e. vimentin and fibronectin), (8,9) epithelial specific markers (i.e. E-cadherin and cytokeratin), (10,11) and transcription factors (i.e. SNAIL and SLUG). (12) Most recently, several intriguing studies have described the novel mechanism underlying EMT activation. In the current study, we will discuss the role of small non-coding RNA (micro-RNA) in regulating EMT-r...

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“…Moreover, FDC-6 positive Fn has also been shown to be reexpressed in several human tumours like ovarian, mammary, and colorectal carcinomas and was suggested to have a possible predictive value (Loridon-Rosa et al 1990;Kaczmarek et al 1994;Inufusa et al 1995;Menzin et al 1998). Additionally, the mRNA expression of the oncofoetal IIICS region representing the de novo glycosylation site was shown to be speciWc for thyroid papillary and anaplastic carcinomas (Takano et al 1999).…”

Section: Introductionmentioning

confidence: 99%

IIICS de novo glycosylated fibronectin as a marker for invasiveness in urothelial carcinoma of the urinary bladder (UBC)

Richter

Junker

Franz

et al. 2008

J Cancer Res Clin Oncol

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Localization of oncofetal and normal fibronectin in colorectal cancer. Correlation with histologic grade, liver metastasis, and prognosis

Cited by 56 publications

References 30 publications

Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study.

Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study.

Epithelial–mesenchymal transition in cancer development and its clinical significance

IIICS de novo glycosylated fibronectin as a marker for invasiveness in urothelial carcinoma of the urinary bladder (UBC)

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