Localization of Cu/Zn and Mn superoxide dismutase in various thyroid disorders

Iwase, Katsumi; Nagasaka, Akio; Kato, Kanefusa; Ohtani, Susumu; Tsujimura, Tohru; Inagaki, Asako; Jimbo, Shin; Nakai, Asami; Masunaga, Rumi; Hamada, Michiko; Mano, Takamitsu; Kotake, Motoko; Miura, Kaoru

doi:10.1530/acta.0.1290573

Cited by 16 publications

(13 citation statements)

References 13 publications

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“…Other authors have estimated the concentration rates of Cu/Zn in the cancerous thyroid tumor were significantly higher than in the normal and other thyroid diseases. 16,17 This study also confirmed that the cancerous thyroid tissues have higher Cu concentrations than the non-cancerous (adenoma) thyroid…”

Section: Determination Of Copper and Zinc In Human Thyroid Tissuessupporting

confidence: 73%

Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Yaman

Akdeniz

2004

ANAL. SCI.

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Various designs of quartz tube in a slotted tube atom trap were examined for improving the sensitivity of flame AAS. A 3.5-fold enhancement in the sensitivity was obtained by using the optimized method. The method was applied to the determination of Cu in cancerous and non-cancerous human thyroid tissues. The Cu concentrations of the cancerous samples tended to increase compared with the non-cancerous samples. Zn concentrations of the same tissues were also determined.

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Section: Determination Of Copper and Zinc In Human Thyroid Tissuessupporting

confidence: 73%

Sensitivity Enhancement in Flame Atomic Absorption Spectrometry for Determination of Copper in Human Thyroid Tissues

Yaman

Akdeniz

2004

ANAL. SCI.

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“…In opposite to our results Reddy et al (16) have reported lower levels of Cu in the tissue of cancerous thyroid than in normal thyroid tissue and like our results (our results are refl ecting serum levels), much lower levels of Cu in the tissue of thyroid adenoma. Other authors have estimated the concentration rates of Cu/Zn in the cancerous thyroid tumour were signifi cantly higher than in the normal and other thyroid disease (12,17,18).…”

Section: Discussionmentioning

confidence: 94%

Serum copper levels in benign and malignant thyroid diseases

Kosova

Çetin²,

Akıncı³

et al. 2012

BLL

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Abstract:Objective: To examine the changes in serum copper (Cu) levels in benign and malignant thyroid disease in humans. Background: Thyroid hormones infl uence the metabolism of trace elements including copper. Methods: 47 papillary thyroid cancer and 43 benign multinodular goitre patients who underwent total thyroidectomy and 37 healthy control subjects were included into this study. All of the patients and controls were females. Serum Cu levels were detected with atomic absorption spectrophotometer. Results: In the papillary thyroid cancer group serum level of Cu was 131.61±33.9 μg/dL before surgery and 120.81±30.4 μg/dL after 20 days from surgery. In the benign group serum Cu level was 84.75±12.1 μg/dL and 68.01±9.4 μg/dL postoperatively.These results were compared to healthy control's value of 105.87±10.68 μg/dL. In the papillary thyroid cancer group pre-and postoperative serum Cu level was signifi cantly higher when compared to control group (p<0.05). Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level(p<0.05), in which, it was still higher than the control(p<0.05). In the benign group pre-and postoperative serum Cu level was significantly lower than in the control group (p<0.05).Postoperative serum Cu level signifi cantly decreased when compared to pre-operative level in the benign group (p<0.05). Conclusion: This is a pioneer study to examine serum Cu level in benign and malignant thyroid patients compared to controls. In our small groups serum Cu levels increased in malignant thyroid patients and decreased in the benign group (Tab. 1, Ref. 18 Trace elements are essential micro-nutrients both for humans and other organisms. They are crucial for many physiological processes and are involved in many pathologic changes in tissues (1). Thyroid hormones infl uence the metabolism of trace elements including copper (Cu) (2). Cu is important for the activity of the enzyme superoxide dismutase (SOD). Changes in the activity of this enzyme are consistent with the Cu serum levels (3). Cu was shown to be essential for cell division both in normal and cancerous tissue (4, 5). Although copper is an essential element for human and animals, a high concentration of Cu (above normal) could induce growth proliferation and cancer by damaging DNA with toxic free hydroxyl radicals (6).The present study was undertaken to investigate correlation of Cu serum levels in benign and malign thyroid diseases before and after surgery compared to controls. Materials and methodsThis is an age-and sex-matched case-control study, conducted at the Department of Medical Biochemistry of Celal Bayar University of Medicine and the Department of General Surgery of Ankara Oncology Hospital, Ankara, Turkey. The study was approved by the hospital Ethical committee. All the patients and the volunteers involved in the study have given informed consent. PatientsRecruitment of subjects was performed by convenience sampling at outpatient General Surgery Clinic of Oncology Hospital, Turkey by trained physicians. 47...

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“…Growth factor levels appeared to be increased (VEGF-A, 5.6-fold; EGFL9, 8.9-fold; PDGFC and PDGFRB, 8.4-and 3.8-fold, respectively; IGF1R, 2.2-fold; and IGBP1, 30-fold) in post-Chernobyl PTC group compared to the control PTC group, thus supporting the hypothesis that aggressiveness, lymph node metastasis and venous invasion might be linked with growth factor mRNA levels. Likewise, it has been shown by many authors that increased mRNA or protein levels of oxidoreductases such as cyclooxygenase 2 (PTGS2), superoxide dismutase (SOD1) and, in some studies, thyroid peroxidase (TPO) are characteristic of thyroid malignancies (42)(43)(44)(45), which was again linked with age (46) and poorer prognosis. In our experiments, mRNA levels of TPO and SOD3 measured in post-Chernobyl PTC appeared to be increased twoand 3.4-fold over the control group, respectively, again supporting the hypothesis that tumor aggressiveness could be linked to oxidoreductase mRNA levels.…”

Section: Figmentioning

confidence: 99%