Localization of Angiogenic Growth Factors and Their Receptors in the Human Placental Bed Throughout Normal Human Pregnancy

Schießl, Barbara; Innes, Barbara A.; Bulmer, Judith N.; Otun, Harry A.; Chadwick, Thomas; Robson, Stephen C.; Lash, Gendie E.

doi:10.1016/j.placenta.2008.10.004

Cited by 114 publications

(60 citation statements)

References 33 publications

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“…(1) VEGF: there is an up-regulated expression of VEGF and its receptors during the early stages of gestation (Ghosh et al 2000, Schiessl et al 2009) that directly or indirectly results in endometrial perfusion, trophoblast proliferation, and trophoblast invasion (Staun-Ram & Shalev 2005). These findings taken together with the observation that VEGF and its receptors are down-regulated in placental samples of pre-eclampsia (Zhou et al 2002, Jarvenpaa et al 2009) suggest that a defect in angiogenic function may result in defective trophoblastic invasion and placentation process (Jauniaux et al 2003, Prefumo et al 2004, Ferretti et al 2007).…”

Section: Anti-vegf On Implantation-stage Endometriummentioning

confidence: 99%

IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey

Ghosh¹,

Najwa²,

Khan³

et al. 2011

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Blastocyst implantation in the rhesus monkey is inhibited by administration of antibody against vascular endothelial growth factor (VEGF) A during peri-implantation period with no change in the circulatory concentrations of estradiol, progesterone, and VEGF. In this study, we have investigated the effect of administration of a MAB to VEGFA on days 5 and 10 after ovulation upon the mRNA expression, immunopositive protein expression, and immunohistological localization of IGF2, IGF binding protein 1 (IGFBP1) and matrix metalloproteinases (MMPs) 2 and 9 in the implantation-stage endometrium collected on day 13 after ovulation from fecund cycles of rhesus monkeys. The comparison between isotype-matched IgG (control; nZ8)-and VEGF antibody (VEGF Mab; nZ8)-treated animals revealed higher (P!0.05) IGF2 in lacunar and villous syncytiotrophoblasts, trophoblast cell columns, migrating extravillous trophoblast cells, and endovascular trophoblast cells in control animals, but with no change in the various cell types of maternal endometrium between the two groups. No change in IGFBP1 expression in the endometrium was observed between the two groups. MMPs 2 and 9 were detected in syncytiotrophoblast in lacunae and villi, trophoblast cell columns, and extravillous trophoblast cells in control samples. MMP9 transcript expression in maternal endometrium and its immunopositivity in endometrial stroma and trophoblast cells were lower (P!0.05) with no change in MMP2 level in VEGF Mab-exposed samples compared with those in control samples. A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.

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Section: Anti-vegf On Implantation-stage Endometriummentioning

confidence: 99%

IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey

Ghosh¹,

Najwa²,

Khan³

et al. 2011

Reproduction

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“…31 Recently the expression of VEGF-C in the endometrium and placenta found to play a critical role in implantation and successful pregnancy. 32 Additionally, uterine natural killer cells (NK cells) express high levels of mRNAs for VEGF-C that adds to the liability of VEGF-C and its role in pregnancy outcome.…”

Section: Bagheri a Et Al Int J Reprod Contracept Obstet Gynecol 201mentioning

confidence: 99%

Angiogenic factors in relation to embryo implantation

Bagheri

Chianeh

Kumar

et al. 2014

Int J Reprod Contracept Obstet Gynecol

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“…In addition, vascular endothelial growth factor C is secreted at higher levels from the first trimester EVTs (HTR8) compared with the third trimester and term trophoblasts, further establishing the differential function of the first trimester cells. Localization of angiogenic growth factors in the placental bed has further established the angiogenic potential of different trophoblast subtypes (Schiessl et al 2009). Figure 1 Aggrewell-generated combination EBs.…”

Section: Esc-derived Trophoblasts: Modeling Endovascular Invasion Andmentioning

confidence: 99%

Embryonic stem cells as models of trophoblast differentiation: progress, opportunities, and limitations

Golos

Giakoumopoulos²,

Garthwaite³

2010

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While the determination of the trophoblast lineage and the facilitation of placental morphogenesis by trophoblast interactions with other cells of the placenta are crucial components for the establishment of pregnancy, these processes are not tractable at the time of human implantation. Embryonic stem cells (ESCs) provide an embryonic surrogate to derive insights into these processes. In this review, we will summarize current paradigms which promote trophoblast differentiation from ESCs, and potential opportunities for their use to further define signals directing morphogenesis of the placenta following implantation of the embryo into the endometrium.

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Localization of Angiogenic Growth Factors and Their Receptors in the Human Placental Bed Throughout Normal Human Pregnancy

Cited by 114 publications

References 33 publications

IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey

IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey

Angiogenic factors in relation to embryo implantation

Embryonic stem cells as models of trophoblast differentiation: progress, opportunities, and limitations

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