Localization of a gene for the human low-voltage EEG on 20q and genetic heterogeneity

Steinlein, Ortrud K.; Anokhin, Andrey P.; Yping, Mao; Schalt, E; Vogel, Friedrich

doi:10.1016/0888-7543(92)90408-k

Cited by 87 publications

(34 citation statements)

References 16 publications

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“…For some rare EEG variants, a Mendelian pattern of autosomal dominance is seen (Vogel 1970). The localization of a gene for this EEG variant has recently been determined (Anokhin et al 1992;Steinlein et al 1992). Most studies used only a limited number of subjects, and none of the studies quantified the genetic contribution as a function of age and sex.…”

Section: Resultsmentioning

confidence: 99%

“…The distribution of this EEG variant is bimodal and segregation analyses support an autosomal dominant mode of inheritance (Anokhin et al 1992;Vogel and G6tze 1959). Evidence for linkage with a marker on the distal part of chromosome 20q was found in a subset of 17 families with the low-voltage EEG variant (Steinlein et al 1992). …”

Section: Genetics Of Rare Eeg Variantsmentioning

confidence: 88%

“…For some EEG variants such as the lowvoltage EEG (found in about 4% of the adult population), a Mendelian pattern of autosomal dominance is seen (Vogel 1970). The localization of a gene for this EEG variant has recently been reported (Anokhin et al 1992;Steinlein et al 1992). Studies in animals suggest that 30% of all genes are expressed specifically in the brain (Sutcliffe and Milner 1984).…”

Section: Discussionmentioning

confidence: 99%

“…Two p-variants showed a Mendelian pattern of autosomal dominance (Vogel 1966a, b), but most ~3-variants showed a model of multifactorial inheritance (Vogel and G6tze 1962;Vogel 1966a). Recently, Steinlein et al (1992) reported the localization of a gene responsible for a low-voltage or variant that is characterized by the almost complete absence of (;(-waves in occipital leads. The distribution of this EEG variant is bimodal and segregation analyses support an autosomal dominant mode of inheritance (Anokhin et al 1992;Vogel and G6tze 1959).…”

Section: Genetics Of Rare Eeg Variantsmentioning

confidence: 99%

“…Recently, Steinlein et al (1992) reported the localization of a gene responsible for a low-voltage or variant that is characterized by the almost complete absence of (;(-waves in occipital leads. The distribution of this EEG variant is bimodal and segregation analyses support an autosomal dominant mode of inheritance (Anokhin et al 1992;Vogel and G6tze 1959). Evidence for linkage with a marker on the distal part of chromosome 20q was found in a subset of 17 families with the low-voltage EEG variant (Steinlein et al 1992).…”

Section: Genetics Of Rare Eeg Variantsmentioning

confidence: 99%

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Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review

1994

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Twin and family studies of normal variation in the human electroencephalogram (EEG) and event related potentials (ERPs) are reviewed. Most of these studies are characterized by small sample sizes. However, by summarizing these studies in one paper, we may be able to gain some insight into the genetic influences on individual differences in central nervous system functioning that may mediate genetically determined differences in behavior. It is clear that most EEG parameters are to a large extent genetically determined. The results for ERPs are based on a much smaller number of studies and suggest medium to large heritability.

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Section: Resultsmentioning

confidence: 99%

Section: Genetics Of Rare Eeg Variantsmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Genetics Of Rare Eeg Variantsmentioning

confidence: 99%

Section: Genetics Of Rare Eeg Variantsmentioning

confidence: 99%

See 3 more Smart Citations

Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review

1994

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Common subtypes of idiopathic generalized epilepsies: Lack of linkage to D20S19 close to candidate loci (EBN1, EEGV1) on chromosome 20

Sander¹,

Hildmann

Wienker

et al. 1996

Am. J. Med. Genet.

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Hereditary factors play a major role in the etiology of idiopathic generalized epilepsies (IGEs). A trait locus (EBN1) for a rare subtype of IGEs, the benign neonatal familial convulsions, and a susceptibility gene (EEGV1) for the common human low‐voltage electroencephalogram have been mapped close together with D20S19 to the chromosomal region 20q13.2. Both loci are potential candidates for the susceptibility to IGE spectra with age‐related onset beyond the neonatal period. The present study tested the hypothesis that a putative susceptibility locus linked to D20S19 predisposes to spectra of IGEs with age‐related onset from childhood to adolescence. Linkage analyses were conducted in 60 families ascertained through IGE patients with juvenile myoclonic epilepsy, juvenile absence epilepsy or childhood absence epilepsy. Our results provide evidence against linkage of a putative susceptibility gene for four hierarchically broadened IGE spectra with D20S19 assuming tentative single‐locus genetic models. The extent of an “exclusion region” (lod scores below − 2) varied from 0.5 cM up to 22 cM on either side of D20S19 depending on the trait assumed. These results are contrary to the expectation that a susceptibility gene in vicinity to D20S19 confers a common major gene effect to the expression of IGE spectra with age‐related onset from childhood to adolescence. © 1996 Wiley‐Liss, Inc.

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Neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) and panic disorder: An association study

et al. 1997

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Anxiety disorders have been reported to be associated with low-voltage EEG (LVEEG). Some cases with LVEEG (approximately 1/3) have been linked to chromosome 20q13.2q13.3. In the same chromosomal region, the gene for the neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) has been located. We therefore tested the hypothesis that polymorphisms in the CHRNA4 gene show an allelic association with panic disorder. We examined the allele frequencies of three different CHRNA4 polymorphisms in patients with panic disorder and in healthy controls. No significant differences in the allele frequencies of these three polymorphisms were noted. This study does not support an association between panic disorder and the CHRNA4 gene.

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Localization of a gene for the human low-voltage EEG on 20q and genetic heterogeneity

Cited by 87 publications

References 16 publications

Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review

Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review

Common subtypes of idiopathic generalized epilepsies: Lack of linkage to D20S19 close to candidate loci (EBN1, EEGV1) on chromosome 20

Neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) and panic disorder: An association study

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