Common subtypes of idiopathic generalized epilepsies: Lack of linkage to D20S19 close to candidate loci (EBN1, EEGV1) on chromosome 20

Abstract

Hereditary factors play a major role in the etiology of idiopathic generalized epilepsies (IGEs). A trait locus (EBN1) for a rare subtype of IGEs, the benign neonatal familial convulsions, and a susceptibility gene (EEGV1) for the common human low‐voltage electroencephalogram have been mapped close together with D20S19 to the chromosomal region 20q13.2. Both loci are potential candidates for the susceptibility to IGE spectra with age‐related onset beyond the neonatal period. The present study tested the hypothesis that a putative susceptibility locus linked to D20S19 predisposes to spectra of IGEs with age‐related onset from childhood to adolescence. Linkage analyses were conducted in 60 families ascertained through IGE patients with juvenile myoclonic epilepsy, juvenile absence epilepsy or childhood absence epilepsy. Our results provide evidence against linkage of a putative susceptibility gene for four hierarchically broadened IGE spectra with D20S19 assuming tentative single‐locus genetic models. The extent of an “exclusion region” (lod scores below − 2) varied from 0.5 cM up to 22 cM on either side of D20S19 depending on the trait assumed. These results are contrary to the expectation that a susceptibility gene in vicinity to D20S19 confers a common major gene effect to the expression of IGE spectra with age‐related onset from childhood to adolescence. © 1996 Wiley‐Liss, Inc.

100 Jahre Dieter Janz

“…Die anderen 4 Mitarbeiter waren: Karl-Friedrich Masuhr [13,14], Hans-Wolfgang Kölmel [15], Dieter Schmidt [16] und Peter Wolf [2,3,17]. In Berlin wurden dann unter anderem Friedhelm Lamprecht (ab 1974), Gisela Schüler (ab 1974) [18], Mechthilde Kütemeyer (ab 1975) [14], Rupprecht Thorbecke (ab 1975) [18][19][20], Gertrud Beck-Mannagetta (ab 1976) [21][22][23], Friedrich Behse (ab 1977) und Hans-Joachim Meencke (ab 1979) [24,25] seine Mitarbeiter. Mit Letzterem publizierte Dieter Janz zur Neuropathologie der primär generalisierten Epilepsien (nach heutiger Klassifikation: genetische generalisierte Epilepsien [26,27]).…”

“…Mit Letzterem publizierte Dieter Janz zur Neuropathologie der primär generalisierten Epilepsien (nach heutiger Klassifikation: genetische generalisierte Epilepsien [26,27]). Diese Publikationen [24,25] bildeten das strukturelle Pendant zu seiner klinisch-phänomenologischen Beschreibung des "Impulsiv-Petit Mal", im Verlauf folgten weitere Publikationen zu den genetischen Ursachen der JME [21][22][23].…”