Local Versus Global Mechanical Effects of Intramural Swelling in Carotid Arteries

Sorrentino, T. A.; Fourman, L.; Ferruzzi, Jacopo; Miller, Kristin S.; Humphrey, Jay D.; Roccabianca, Sara

doi:10.1115/1.4029303

Cited by 13 publications

(12 citation statements)

References 17 publications

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“…The rat esophagus also displayed a positive correlation between collagen content and opening angle (Fan et al 2005). Prior work implicates that elastin (Greenwald et al 1997) and GAGs (Guo et al 2007, Sorrentino et al 2015b, Azeloglu et al 2008) significantly contribute to residual strain in addition to collagen fibers. No significant differences in elastin area fraction, however, were identified along the length of the reproductive system, thus suggesting collagen fibers may dominate the regional differences observed in this study.…”

Section: Discussionmentioning

confidence: 99%

“…These positions included the upper right and left uteri near the ovary (UOV), right and left mid-uterus (U), right and left uteri near the mid-cervix (UCER), mid-cervix (CER), external os/vaginal cervix (VCER), and the vagina (V) (Fig 1). One ring from each of the pairs was randomly placed in 33% hypo-osmotic HBSS with 46 mM sodium chloride while the other ring remained in control HBSS with 134 mM sodium chloride (Sorrentino et al 2015b). Following a 30 min equilibration, the rings were imaged with a Moticam 580 microscope camera (Motic, Inc., Richmond, British Columbia, Canada).…”

Section: Methodsmentioning

confidence: 99%

“…In addition to differences in the growth and remodeling state, it is understood that the constituent makeup of the female reproductive system varies significantly with region, which may result in a spatial variability of the stress-free state of the tissue. It has also been suggested that tissue osmotic-induced swelling is closely linked to the residual stress due to turnover of the water sequestering glycosaminoglycans (GAGs) that are inherent in the ECM of women’s reproductive organs (Guo, Lanir and Kassab 2007, Sorrentino et al 2015a, Azeloglu et al 2008). Therefore, the objective of this study is to quantify the effects of estrous cycle, spatial variation (beginning at the ovaries and moving distally to the vagina), and hypo-osmotic loading on residual strain by means of opening angle experiments.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating residual strain throughout the murine female reproductive system

Capone

Clark

Bivona

et al. 2019

Journal of Biomechanics

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Mounting evidence suggests that cells within soft tissues seek to maintain a preferred biomechanical state. Residual stress is defined as the stress that remains in a tissue when all external loads are removed and contributes to tissue mechanohomeostasis via decreasing the transmural gradient of wall stress. Current computational models of pelvic floor mechanics, however, often do not consider residual stress. Residual strain, a result of residual stress can be quantitatively measured through opening angle experiments. Therefore, the objective of this study is to quantify the regional variations in opening angles along the murine female reproductive system at estrus and diestrus to quantify residual strain in the maintenance state of sexually mature females. Further, evidence suggests that hydrophilic glycosaminoglycan/proteoglycans are integral to cervical remodeling. Thus, variations in opening angles following hypo-osmotic loading are evaluated. Opening angle experiments were performed along the murine reproductive system in estrus (n = 8) and diestrus (n = 8) and placed in hypo-osmotic solution. Measurements of thickness and volume were also obtained for each group. Differences in opening angle were observed with respect to region and loading (p < 0.05), however, no differences with respect to estrus stage were significant. Thickness values were significant with respect to region, (p < 0.05) only. The effects of both estrous cycle and region (p < 0.05) resulted in significant differences in observed volume. The observed regional differences indicate changes in the stress-free state of each tissue which may have implications for future computational models to advance women’s reproductive health.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating residual strain throughout the murine female reproductive system

Capone

Clark

Bivona

et al. 2019

Journal of Biomechanics

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“…34 The model also provides an intriguing explanation for the detection of foci of GAGs in the outer media of diseased aortas, which are considered to induce significant stress concentrations and intralamellar Donnan swelling pressures. 35,36 The mechanism behind increased detection of GAGs is unknown, but the current paradigm refers to increased GAG production. 37,38 The model presented here suggests an additional or alternative mechanism whereby access of fluid to the interstitial space (secondary to alteration of microvascular tone and Pif) will inevitably induce swelling of the osmotically active and underhydrated GAGs, leading to expansion of the vessel area occupied by GAGs.…”

Section: Pathophysiological Predictions Of the Modelmentioning

confidence: 99%

“…35,36 The mechanism behind increased detection of GAGs is unknown, but the current paradigm refers to increased GAG production.…”

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confidence: 99%

Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid

Mallat

Tedgui

Henrion

2016

ATVB

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G enetic mutations that predispose to thoracic aortic aneurysms and aortic dissections (TAADs) affect structural components of the extracellular matrix (ECM), transmembrane structures involved in mechanical integrity, mechanosensing, and signal transduction, or intracellular components of the cell contractile apparatus. [1][2][3] Concepts and studies are being developed to explain how such alterations may impact the response of the aorta to hemodynamic stress and drive abnormal aortic remodeling. 4 Here, we propose a focus shift toward the small vessels (arterioles and vasa vasorum) to explain, based on current knowledge about the (patho)physiology of blood flow regulation and fluid dynamics, how alterations in ECM and the cell contractile apparatus may instigate the frightening process of aortic dissection. Microcirculatory Vascular Tone and the Autoregulation of Blood Flow: The Example of Myogenic ToneMicrocirculatory vascular tone is the main determinant of vascular resistance and ensures tissue perfusion in response to changing metabolic demands. An increase in pressure induces a rapid and reversible vasoconstriction of small resistance vessels, an intrinsic property because of their ability to develop myogenic tone (MT). 5 Besides protecting downstream capillaries from abrupt increases in blood pressure occurring in larger vessels, MT has a key role in the inward eutrophic vascular remodeling in response to a chronic rise in pressure.Pressure induces deformation of cell membrane proteins such as stretch-activated ion channels; conformational changes in matrix and cytoskeletal proteins; activation of ECM and integrins; and activation of various cellular junctions (Figure 1). Vascular smooth muscle cell (SMC) depolarization and calcium entry are necessary for the development of pressure-induced contraction and myogenic tone. Although the nature of the channel(s) involved in MT development remains debated, canonical transient receptor potential (TRP) channels are strong candidates. Interactions of TRP polycystin 1 and 2 (TRPP1 and TRPP2) with filamin A, an actin crosslinking protein, are critical for stretch-activated ion channel regulation and MT development.6 Indirect evidence for a role of chloride © 2016 American Heart Association, Inc. Abstract-The pathophysiology of aortic dissection is poorly understood, and its risk is resistant to medical treatment. Most studies have focused on a proposed pathogenic role of transforming growth factor-β in Marfan disease and related thoracic aortic aneurysms and aortic dissections. However, clinical testing of this concept using angiotensin II type 1 receptor antagonists to block transforming growth factor-β signaling fell short of promise. Genetic mutations that predispose to thoracic aortic aneurysms and aortic dissections affect components of the extracellular matrix and proteins involved in cellular force generation. Thus, a role for dysfunctional mechanosensing in abnormal aortic wall remodeling is emerging. However, how abnormal mechanosensing leads to aortic dis...

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Bulging initiation and propagation in fiber-reinforced swellable Mooney–Rivlin membranes

et al. 2021

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This article considers a thin-walled hollow cylinder, which is composed of a fibrous and swellable hyperelastic material. The fibers are arranged in two families and they are taken to be parallel within each fiber family. The two fiber families are also assumed to be mechanically equivalent and symmetrically disposed in the ground substance material. At each instant of the homogeneous swelling, the material is taken to be incompressible. This article studies the interplay of swelling, fiber orientation, and the mechanical properties of the constituents on the initiation as well as on the axial propagation of bulging.

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Local Versus Global Mechanical Effects of Intramural Swelling in Carotid Arteries

Cited by 13 publications

References 17 publications

Evaluating residual strain throughout the murine female reproductive system

Evaluating residual strain throughout the murine female reproductive system

Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid

Bulging initiation and propagation in fiber-reinforced swellable Mooney–Rivlin membranes

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