Local treatment of tendinopathies and myofascial painsyndromes with the 5‐HT<sub>3</sub>receptor antagonist tropisetron

Müller, Wolfgang; Stratz, T

doi:10.1080/03009740410007032

Cited by 47 publications

(32 citation statements)

References 11 publications

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“…For example, the serotonin antagonist tropisetron inhibited the pronociceptive or pain-promoting effect of serotonin at trigger points. 221 Other relevant substances include nerve growth factor, 222 which can also stimulate TRPV receptors, 223 brain-derived neurotrophic factor, 224,225 and nitric oxide, 226,227 but a detailed discussion of their potential roles is beyond the scope of this review.…”

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confidence: 99%

Dry needling — peripheral and central considerations

Dommerholt¹

2011

Journal of Manual & Manipulative Therapy

216

140

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Dry needling is a common treatment technique in orthopedic manual physical therapy. Although various dry needling approaches exist, the more common and best supported approach targets myofascial trigger points. This article aims to place trigger point dry needling within the context of pain sciences. From a pain science perspective, trigger points are constant sources of peripheral nociceptive input leading to peripheral and central sensitization. Dry needling cannot only reverse some aspects of central sensitization, it reduces local and referred pain, improves range of motion and muscle activation pattern, and alters the chemical environment of trigger points. Trigger point dry needling should be based on a thorough understanding of the scientific background of trigger points, the differences and similarities between active and latent trigger points, motor adaptation, and central sensitize application. Several outcome studies are included, as well as comments on dry needling and acupuncture.

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confidence: 99%

Dry needling — peripheral and central considerations

Dommerholt¹

2011

Journal of Manual & Manipulative Therapy

216

140

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“…Local injections of topisetron, a 5-hydroxytryptamine3 receptor antagonist, may contribute to rapid and prolonged relief, with an analgesic effect far superior to the action of local anaesthetics 70 . The efficacy of this drug has also been attributed to its antiphlogistic effect, which may be related to the inhibited release of substance P and other neuropeptides from nociceptors, and the blocked release of phlogistic substances from macrophages, monocytes, etc 22,69,70,91 .…”

Section: Discussionmentioning

confidence: 99%

Myofascial pain syndromes in the maxillofacial area: a common but underdiagnosed cause of head and neck pain

Manolopoulos¹,

Vlastarakos²,

Georgiou³

et al. 2008

International Journal of Oral and Maxillofacial Surgery

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“…Sieben Tage nach den Injektionen war der Effekt bei den mit Tropisetron behandelten Patienten noch sehr deutlich, dagegen bei den mit Prilocain therapierten nur geringfügig. Nach 8 Wochen zeigten noch 10 der 17 mit Tropisetron behandelten Patienten, dagegen nur 2 der 16 mit Lidocain therapierten Fälle eine gute Beeinflussung der lokalen Schmerzzustände [12]. Auch die Behandlung von Triggerpunkten mit Tropisetron bei Patienten mit Schmerzzuständen nach HWSSchleudertrauma ergaben sehr befriedigende Resultate, wenn der Effekt auch keineswegs in allen Fällen gleich war [3].…”

Section: Tab 2 Nebenwirkungen Bei 10-tägiger Behandlung Mit Tropisetunclassified

5-HT3-Rezeptor-Antagonisten als Analgetika bei rheumatischen Erkrankungen

Müller

Fiebich²,

Stratz

2006

Z. Rheumatol.

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Various rheumatic diseases like fibromyalgia, systemic inflammatory rheumatic disorders and localized diseases, such as arthritides and activated arthroses, tendinopathies and periarthropathies, as well as trigger points can be improved considerably by treatment with the 5-HT3 receptor antagonist tropisetron. Particularly in the latter group of diseases, local injections have done surprisingly rapid analgesic action. This effect matches that of local anesthetics, but lasts considerably longer and is comparable to local injections of local anesthetics combined with corticosteroids. The action of the 5-HT3 receptor antagonists can be attributed to an antinociceptive effect that occurs at the same time as an antiphlogistic and probably also an immunosuppressive effect. Whereas an inhibited release of substance P from the nociceptors, and possibly some other neurokins as well, seems to be the most likely explanation for the antinociceptive action, the antiphlogistic effect is primarily due to an inhibited formation of various different phlogistic substances; in some conditions, like systemic inflammatory rheumatic diseases, for example, the 5-HT3 receptor antagonists may exert an immunosuppressive effect in addition to this.

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Local treatment of tendinopathies and myofascial painsyndromes with the 5‐HT₃receptor antagonist tropisetron

Cited by 47 publications

References 11 publications

Dry needling — peripheral and central considerations

Dry needling — peripheral and central considerations

Myofascial pain syndromes in the maxillofacial area: a common but underdiagnosed cause of head and neck pain

5-HT3-Rezeptor-Antagonisten als Analgetika bei rheumatischen Erkrankungen

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Local treatment of tendinopathies and myofascial painsyndromes with the 5‐HT3receptor antagonist tropisetron

Cited by 47 publications

References 11 publications

Dry needling — peripheral and central considerations

Dry needling — peripheral and central considerations

Myofascial pain syndromes in the maxillofacial area: a common but underdiagnosed cause of head and neck pain

5-HT3-Rezeptor-Antagonisten als Analgetika bei rheumatischen Erkrankungen

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Local treatment of tendinopathies and myofascial painsyndromes with the 5‐HT₃receptor antagonist tropisetron