Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: Implications for adjuvant therapy

Chen, Allen M.; Granchi, Phillip J.; García, Joaquín J.; Bucci, M. Kara; Fu, Karen K.; Eisele, David W.

doi:10.1016/j.ijrobp.2006.10.043

Cited by 111 publications

(117 citation statements)

References 31 publications

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“…Treatment with surgery and adjuvant radiotherapy in locally advanced disease, high grade histology, lymph node or facial nerve involvement and close or positive margins has been shown to provide excellent rates of local control and survival with modest toxicity (Toonkel et al, 1994;Chen et al, 2007;Moriniere et al, 2007). All the patients in the present study underwent conventional radiotherapy.…”

Section: Discussionmentioning

confidence: 94%

“…Post-operative radiotherapy (PORT) has been shown to be an independent prognostic factor for major salivary gland cancer (Shang et al, 2005). PORT should be considered for all patients with lymph node metastasis, high grade tumour, positive margins, and T3-4 stage that predict higher rates of LRR after surgery for carcinomas of the major salivary glands (Chen et al, 2007). Histology is an important prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

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Outcome of Surgery and Post-Operative Radiotherapy for Major Salivary Gland Carcinoma: Ten Year Experience from a Single Institute

Kaur

Goyal²,

Muzumder³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Outcome of Surgery and Post-Operative Radiotherapy for Major Salivary Gland Carcinoma: Ten Year Experience from a Single Institute

Kaur

Goyal²,

Muzumder³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In cases in which surgery is not possible, radiotherapy alone has been used, but with inferior results 8,[12][13][14][15][16][17][18] . The role of adjuvant radiation therapy (rt) after surgery varies widely depending on the centre [19][20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Siever

Hao

et al. 2016

Current Oncology

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Objectives Adenoid cystic carcinoma (acc) is often treated with surgery, with or without adjuvant radiation therapy (rt). We evaluated disease characteristics, treatments, and potentially prognostic variables in patients with acc.Methods Our retrospective analysis considered consecutive cases of acc presenting at a tertiary care hospital between 2000 and 2014. Factors predictive of overall survival (os) and disease-free survival (dfs) were identified by univariate analysis. ResultsThe 60 patients analyzed had a mean age of 58 years (range: 22-88 years), with a 2:1 female:male ratio. Tumour locations included the major salivary glands (40% parotid, 17% submandibular and sublingual), the oro-nasopharyngeal cavity (27%), and other locations (16%). Of the 60 patients, 35 (58%) received surgery with adjuvant rt; 12 (20%), rt only; 13 (22%), surgery only. Of 18 patients (30%) who experienced a recurrence within 5 years, 3 (5%) developed local recurrence only, and the remaining 15 (25%), distant metastasis. The 5-year os and dfs were 64.5% [95% confidence interval (ci): 45.9% to 78.1%] and 46.2% (95% ci: 29.7% to 61.2%) respectively. In patients without recurrence, 5-year os was 77% (95% ci: 52.8% to 89.9%), and in patients with recurrence, it was 42.7% (95% ci: 15.8% to 67.6%). Patients treated with rt only had a 5-year os of 9.2%. Predictors of 5-year dfs were TNM stage, T stage, nodal status, treatment received, and margin status; age, nodal status, treatment received, and margin status predicted 5-year os.Conclusions Despite surgery and rt, one third of patients with acc experience distant recurrence. Patients whose tumours are not amenable to surgery have a poor prognosis, indicating a need for alternative approaches to improve outcomes.

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“…Radiotherapy is recommended for high-grade MECs and patients with perineural invasion, positive margins and T3-4 classiication [64,65]. For patients with increased risk of nodal metastasis, elective neck irradiation may be applicable [32,66].…”

Section: Managementmentioning

confidence: 99%

Salivary Gland Cancers: A Survey through History, Classifications and Managements

Khosravi¹,

Bagherihagh²,

Saeedi³

et al. 2017

Diagnosis and Management of Head and Neck Cancer

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In this chapter, we are going to discuss about salivary glands cancers, their clinical manifestations and categories, pathogenesis, diagnosis and treatment. We will go through details in each part in both clinical and surgical aspects based on recently prominent published studies and research in prestigious journals. After a short review on clinical features, epidemiology, pathogenesis, diagnosis and treatment, we will show staging and tumor node metastasis (TNM) classiication of major salivary gland tumors and also basic principles of approach to salivary gland cancers. A litle will be explained about basic surgical procedures for removal of cancers and benign tumors.

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Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: Implications for adjuvant therapy

Cited by 111 publications

References 31 publications

Outcome of Surgery and Post-Operative Radiotherapy for Major Salivary Gland Carcinoma: Ten Year Experience from a Single Institute

Outcome of Surgery and Post-Operative Radiotherapy for Major Salivary Gland Carcinoma: Ten Year Experience from a Single Institute

Adenoid Cystic Carcinoma of Head and Neck: Clinical Predictors of Outcome from a Canadian Centre

Salivary Gland Cancers: A Survey through History, Classifications and Managements

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