Outcome of Surgery and Post-Operative Radiotherapy for Major Salivary Gland Carcinoma: Ten Year Experience from a Single Institute

Kaur, Jaspreet; Goyal, Shikha; Muzumder, Sandeep; Bhasker, Suman; Mohanti, Bidhu Kalyan; Rath, Goura Kishore

doi:10.7314/apjcp.2014.15.19.8259

Cited by 27 publications

(27 citation statements)

References 17 publications

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“…This retrospective study focused on the clinical outcomes, prognostic factors, failure patterns, and adverse events in patients with major SGC treated with surgery and postoperative IMRT. Similar to that reported in the literature [3,6,7], our study showed that ACC was the most common histology, followed by LELC. As histology is an important prognostic factor, for SDC, adenocarcinoma and undifferentiated carcinoma have worse prognosis [8,9], we performed an ACC subgroup analysis.…”

Section: Discussionsupporting

confidence: 91%

Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study

Zang¹,

Huang²,

Zhu³

et al. 2020

Preprint

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Background To investigate the outcomes, prognostic factors, patterns of failure, and adverse events in patients with salivary gland cancer (SGC) treated with surgery and postoperative intensity-modulated radiotherapy (IMRT). Methods We identified 60 patients with major SGC treated with surgery followed by postoperative IMRT. Data for overall survival (OS),progression-free survival (PFS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), prognostic factors, and treatment-related toxicities were analyzed. Survival was calculated with the Kaplan–Meier method. Multivariable analysis (MVA) was used to identify prognostic factors for OS, PFS, LRRFS and DMFS. Results Adenoid cystic carcinoma (ACC) was the most common histology ( n =21; 35%). With a median follow-up of 55.5 months, OS and PFS were 90.7%, 85.1%, and 85.1%; and 80.1%, 72.7%, and 63.1%, at 3, 5, and 10 years, respectively. LRRFS and DMFS at 3, 5, and 10 years were 87.4%, 82.1%, and 82.1%; and 85.3%, 78.4%, and 66.1%, respectively. Five-year OS, PFS, LRRFS, and DMFS for ACC was 100%, 67.7%, 76.2%, and 90.2%, respectively. In MVA, N stage was an independent predictor of PFS ( p =0.047). Positive margin was a significant prognostic factor for PFS, LRRFS, and DMFS ( p =0.036, 0.026, and 0.011, respectively). Major nerve involvement was significantly correlated with PFS and DMFS ( p =0.034 and 0.008, respectively). Interval from surgery to radiotherapy (RT) predicted PFS and DMFS ( p =0.036 and 0.012, respectively). The most common acute toxicities were mucositis and dermatitis, and xerostomia was the most common late adverse event. Lung metastasis was the most common pattern of distant failure. Conclusion Postoperative IMRT leads to improved survival for SGC patients with acceptable toxicities.

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Section: Discussionsupporting

confidence: 91%

Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study

Zang¹,

Huang²,

Zhu³

et al. 2020

Preprint

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“…Parotid tumors represent 1-5% of all head and neck tumors and 0.1-0.5 of all human tumors (Lima et al, 2005;Kaur et al, 2014). Malignant parotid neoplasms have low incidence and heterogeneity of histological types (Mercante et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors and Clinical Outcome in Parotid Gland Tumors: a Single Institution Experience from the Eastern Black Sea Region of Turkey

Kandaz

Soydemir²,

Bahat³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…However, application of these molecular targets for treatment is difficult. Radiotherapy immediately after surgery has been reported to improve the prognosis of patients with malignant salivary gland tumors (15). SDC is extremely aggressive, and postoperative radiotherapy and systemic chemotherapy are not effective (11,12).…”

Section: Discussionmentioning

confidence: 99%

Blockade of Androgen-induced Malignant Phenotypes by Flutamide Administration in Human Salivary Duct Carcinoma Cells

Kamata

Sumida

Murase

et al. 2016

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Outcome of Surgery and Post-Operative Radiotherapy for Major Salivary Gland Carcinoma: Ten Year Experience from a Single Institute

Cited by 27 publications

References 17 publications

Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study

Oncological outcome of patients with salivary gland cancer treated with surgery and postoperative intensity-modulated radiotherapy: a retrospective study

Prognostic Factors and Clinical Outcome in Parotid Gland Tumors: a Single Institution Experience from the Eastern Black Sea Region of Turkey

Blockade of Androgen-induced Malignant Phenotypes by Flutamide Administration in Human Salivary Duct Carcinoma Cells

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