Local recurrence of soft tissue sarcoma a risk factor for late metastases: 379 patients followed for 0.5-20 years

Trovik, Clement; Bauer, Henrik C. F.

doi:10.3109/17453679409000913

Cited by 30 publications

(16 citation statements)

References 25 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Probably each increase of size increases the risk for metastatic spread. Trovik et al [11] found that the relative risk for metastatic disease increased by 1.5 per 5 cm increment of tumor size. Suit et al [12] studied 6 groups of size and found an increasing risk of metastases with increasing size.…”

Section: Discussionmentioning

confidence: 99%

Should tumor depth be included in prognostication of soft tissue sarcoma?

Rydholm

Gustafson

2003

BMC Cancer

View full text Add to dashboard Cite

Background: Most staging systems for soft tissue sarcoma are based on histologic malignancygrade, tumor size and tumor depth. These factors are generally dichotomized, size at 5 cm. We believe it is unlikely that tumor depth per se should influence a tumor's metastatic capability. Therefore we hypothesized that the unfavourable prognostic importance of depth could be explained by the close association between size and depth, deep-seated tumors on average being larger than the superficial ones. When tumor size is dichotomized, this effect should be most pronounced in the large size (>5 cm) group in which the size span is larger.

show abstract

Section: Discussionmentioning

confidence: 99%

Should tumor depth be included in prognostication of soft tissue sarcoma?

Rydholm

Gustafson

2003

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…As a prognostic factor, tumor size represents a continuum of increasing risk ( Figure 1). Trovik et al found that the relative risk of metastasis increased by 1.5% per 5 cm increment of tumor size [173]. The importance of size may also be histotype-specific; whereas in leiomyosarcoma, MFH and synovial sarcoma tumor size is a strong prognostic factor for metastasis this is not the case in liposarcoma [55,177].…”

Section: Tumor Sizementioning

confidence: 99%

Prognostic factors in soft tissue sarcomaTissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence

Engellau¹

2004

Acta Orthopaedica Scandinavica

View full text Add to dashboard Cite

“…Before the introduction of chemotherapy, 80-90% of children with osteosarcoma and Ewing's sarcoma died of metastatic disease, despite radical amputation; metastatic spread had occurred long before the primary tumor was diagnosed. That a local recurrence in rare cases is responsible for metastatic spread cannot, of course, be excluded; dedifferentation of a low-grade tumor into a highly malignant tumor may occur, especially after repeated local recurrences (Trovik and Bauer 1994). This phenomenen is well known in retroperitoneal liposarcoma but seems to be rare in extremity sarcomas.…”

Section: Association Between Local Recurrence and Metastasesmentioning

confidence: 99%