Local Pulse Wave Velocity: Theory, Methods, Advancements, and Clinical Applications

Nabeel, P M; Kiran, V Raj; Joseph, Jayaraj; Abhidev, V. V.; Sivaprakasam, Mohanasankar

doi:10.1109/rbme.2019.2931587

Cited by 102 publications

(57 citation statements)

References 261 publications

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“…PWVβ, on the other hand, was the most repeatable measure of the carotid stiffness. It inherently accounts for arterial material properties and nonlinear characteristics of transmural pressure and lumen diameter interaction [5]. Note that the equation for PWVβ (Supplemental Material) is tolerant of error propagation.…”

Section: Potential Of Carotid Stiffness For Risk Assessmentmentioning

confidence: 99%

Assessment of Carotid Arterial Stiffness in Community Settings With ARTSENS®

Joseph

Nabeel

Rao

et al. 2021

IEEE J. Transl. Eng. Health Med.

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Section: Potential Of Carotid Stiffness For Risk Assessmentmentioning

confidence: 99%

Assessment of Carotid Arterial Stiffness in Community Settings With ARTSENS®

Joseph

Nabeel

Rao

et al. 2021

IEEE J. Transl. Eng. Health Med.

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“…We used the sum-of-squares method to determine local coronary wave speed. Several other single-point techniques have been developed and successfully applied to determine local wave speed in larger human arteries (29). These methods are not applicable in coronary vessels for technical reasons related to the necessary transducers or because theoretical requirements cannot be fulfilled for measurements in the coronary circulation, e.g., finding a linear portion in hemodynamic-loop approaches.…”

Section: Limitationsmentioning

confidence: 99%

Usefulness of Proximal Coronary Wave Speed for Wave Intensity Analysis in Diseased Coronary Vessels

Casadonte

Baan

Piek

et al. 2020

Front. Cardiovasc. Med.

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Background: Wave speed is needed to separate net wave intensity into forward and backward traveling components. However, wave speed in diseased coronary arteries cannot be assessed from hemodynamic measurements obtained distal to a stenosis. Wave speed inherently depends on arterial wall properties which should be similar proximal and distal to a stenosis. Our hypothesis is that proximal wave speed can be used to separate net wave intensity obtained distal to a stenosis. Conclusion: In diseased coronary vessels, SPc assessed from distal hemodynamic signals is erroneously elevated. Our findings suggest that proximal wave speed can be used to separate wave intensity profiles obtained downstream of a stenosis. This approach may extend the application of wave intensity analysis to diseased coronary vessels.

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“…(1) While performing measurements on individual cardiac cycles, their diastolic pressure (PD) and corresponding end-diastolic diameter (DD) values can be used as reliable estimates for PR and DR respectively. Therefore, (1) can be further expressed, for a given cardiac cycle, as in (2).…”

Section: Modeling Of Incremental Local Pwvmentioning

confidence: 99%

“…Clinical importance of the blood pulse wave velocity (PWV) measured over small arterial segments, known as the local PWV, is well established in recent years [1,2]. Typically, local PWV from target arterial sites (artery under clinical investigation) is evaluated for a single and the most convenient fiduciary point from each cardiac cycle and averaged over the measurement period.…”

Section: Introductionmentioning

confidence: 99%

“…Non-invasive measurement of incremental local PWV and assessment of the degree of variation over a cardiac cycle is practically challenging using the currently available methodologies [1]. However, considering the clinical importance of incremental local PWV [2], it is essential to introduce a practically feasible solution to assess the instantaneous value of local PWV and trace the locus over continuous cardiac cycles. To our knowledge, the work presented in this paper is the first attempt that has been made to introduce an empirical model to deduce the locus of incremental local PWV over the cardiac cycle using directly measurable physiological parameters.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Incremental Local Pulse Wave Velocity Using Arterial Diameter Waveform: Mathematical Modeling and Practical Implementation

Nabeel¹,

Raj²,

Joseph³

et al. 2019

2019 Computing in Cardiology Conference (CinC)

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Background and Aim: Given the knowledge of the noninvasive assessment of local pulse wave velocity (PWV) for cardiovascular risk stratification, it is apparent that it is necessary to develop a practically feasible solution to measure and trace instantaneous variations in local PWV (incremental local PWV) from the target arteries.Methods: From the arterial blood pulse propagation characteristics, wave nature of the transmural pressure, and the distending vessel wall geometry, a mathematical model was developed to evaluate incremental local PWV using arterial diameter waveform. Its practical feasibility and the measurement accuracy were demonstrated invivo using a custom image-free ultrasound device, with the Bramwell-Hill method as the reference.Results: The proposed technique and developed device reliably captured incremental local PWV from the carotid artery. The locus of instantaneous variations in carotid local PWV obtained using the developed model traced the reference values, with a root-mean-square-error lesser than 0.05 m/s. Study results further established the practical feasibility and accuracy of this novel approach.Conclusion: The theoretical basis and measurement method of this work is a solution for non-invasive, realtime assessment of incremental local PWV and its locus.

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Local Pulse Wave Velocity: Theory, Methods, Advancements, and Clinical Applications

Cited by 102 publications

References 261 publications

Assessment of Carotid Arterial Stiffness in Community Settings With ARTSENS®

Assessment of Carotid Arterial Stiffness in Community Settings With ARTSENS®

Usefulness of Proximal Coronary Wave Speed for Wave Intensity Analysis in Diseased Coronary Vessels

Determination of Incremental Local Pulse Wave Velocity Using Arterial Diameter Waveform: Mathematical Modeling and Practical Implementation

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