Assessment of Carotid Arterial Stiffness in Community Settings With ARTSENS®

Joseph, Jayaraj; Nabeel, P M; Rao, Sudha Ramachandra; Venkatachalam, Ramachandran; Shah, Malay Ilesh; Kaur, Prabhdeep

doi:10.1109/jtehm.2020.3042386

Cited by 28 publications

(6 citation statements)

References 40 publications

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“…Arterial stiffness was assessed by noninvasive, image-free ultrasound technology with the ARTSENS Plus (Healthcare Technology Innovation Center, Indian Institute of Technology Madras, Chennai, India) ( 29 – 32 ). Simultaneous recording of carotid artery distensibility and cuff-based femoral artery blood pressure facilitated assessment of carotid-femoral pulse wave velocity (cf-PWV; m/s), a parameter of central stiffness ( 33 ).…”

Section: Methodsmentioning

confidence: 99%

Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

Sluijs¹,

Bakker²,

Schuijt

et al. 2023

American Journal of Physiology-Heart and Circulatory Physiology

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Coronavirus disease 2019 (COVID-19) is reported to have long-term effects on cardiovascular health and physical functioning, even in the non-hospitalized population. The physiological mechanisms underlying these long-term consequences are however less well-described. We compared cardiovascular risk factors, arterial stiffness and physical functioning in non-hospitalized COVID-19 patients, at a median of six months post-infection, versus age- and sex-matched controls. Cardiovascular risk was assessed using blood pressure and biomarker concentrations (amino-terminal pro-B-type-natriuretic-peptide, high-sensitive cardiac troponin I, C-reactive protein) and arterial stiffness was assessed using carotid-femoral pulse wave velocity. Physical functioning was evaluated using accelerometry, handgrip strength, gait speed and questionnaires on fatigue, perceived general health status and health-related quality of life (hrQoL). We included 101 former COVID-19 patients (age 59 (interquartile range: [55-65]) years, 58% male) and 101 controls. At 175 [126-235] days post-infection, 32% of the COVID-19 group reported residual symptoms, notably fatigue, and 7% required post-COVID-19 care. We found no differences in blood pressure, biomarker concentrations or arterial stiffness between both groups. Former COVID-19 patients showed a higher handgrip strength (43 [33-52] versus 38 [30-48] kg, p=0.004), less sleeping time (8.8 [7.7-9.4] versus 9.8 [8.9-10.3] hours/day, p<0.001) and reported fatigue more often than controls. Accelerometry-based habitual physical activity levels, gait speed, perception of general health status and hrQoL were not different between groups. In conclusion, one in three non-hospitalized COVID-19 patients reports residual symptoms at a median of six months post-infection, but we were unable to relate these symptoms to increases in cardiovascular risk factors, arterial stiffness or physical dysfunction.

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Section: Methodsmentioning

confidence: 99%

Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

Sluijs¹,

Bakker²,

Schuijt

et al. 2023

American Journal of Physiology-Heart and Circulatory Physiology

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“…Strengths of our study are the use of the same validated device to assess central and local arterial stiffness in both cohorts [ 37 , 38 ], the inclusion of a large group of participants, and the inclusion of participants residing in the country of their ethnic origin. However, some limitations are present.…”

Section: Discussionmentioning

confidence: 99%

Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians

van der Sluijs,

Thannhauser,

Visser

et al. 2023

PLoS ONE

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Background Ethnicity impacts cardiovascular disease (CVD) risk, and South Asians demonstrate a higher risk than White Europeans. Arterial stiffness is known to contribute to CVD, and differences in arterial stiffness between ethnicities could explain the disparity in CVD risk. We compared central and local arterial stiffness between White Europeans and South Asians and investigated which factors are associated with arterial stiffness. Methods Data were collected from cohorts of White Europeans (the Netherlands) and South Asians (India). We matched cohorts on individual level using age, sex, and body mass index (BMI). Arterial stiffness was measured with ARTSENS® Plus. Central stiffness was expressed as carotid-femoral pulse wave velocity (cf-PWV, m/s), and local carotid stiffness was quantified using the carotid stiffness index (Beta) and pressure-strain elastic modulus (Epsilon, kPa). We compared arterial stiffness between cohorts and used multivariable linear regression to identify factors related to stiffness. Results We included n = 121 participants per cohort (age 53±10 years, 55% male, BMI 24 kg/m2). Cf-PWV was lower in White Europeans compared to South Asians (6.8±1.9 vs. 8.2±1.8 m/s, p<0.001), but no differences were found for local stiffness parameters Beta (5.4±2.4 vs. 5.8±2.3, p = 0.17) and Epsilon (72±35 vs. 70±31 kPa, p = 0.56). Age (standardized β, 95% confidence interval: 0.28, 0.17–0.39), systolic blood pressure (0.32, 0.21–0.43), and South Asian ethnicity (0.46, 0.35–0.57) were associated with cf-PWV; associations were similar between cohorts (p>0.05 for interaction). Systolic blood pressure was associated with carotid stiffness in both cohorts, whereas age was associated to carotid stiffness only in South Asians and BMI only in White Europeans. Conclusion Ethnicity is associated with central but not local arterial stiffness. Conversely, ethnicity seems to modify associations between CVD risk factors and local but not central arterial stiffness. This suggests that ethnicity interacts with arterial stiffness measures and the association of these measures with CVD risk factors.

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“…78,79 More than a dozen of published articles have claimed the advantages of ARTSENS in clinical applications, including its portability, high-throughput, and efficiency in evaluating vascular wall and stiffness, but a large cohort-based clinical trial has yet to yield any conclusive results. [80][81][82][83] Vascular functional changes are listed in Table 2.…”

Section: Other Methods To Detect Arterial Stiffnessmentioning

confidence: 99%

Vascular Aging: Assessment and Intervention

Li,

Yan,

Zhao

et al. 2023

CIA

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Vascular aging represents a collection of structural and functional changes in a blood vessel with advancing age, including increased stiffness, vascular wall remodeling, loss of angiogenic ability, and endothelium-dependent vasodilation dysfunction. These age-related alterations may occur earlier in those who are at risk for or have cardiovascular diseases, therefore, are defined as early or premature vascular aging. Vascular aging contributes independently to cardio-cerebral vascular diseases (CCVDs). Thus, early diagnosis and interventions targeting vascular aging are of paramount importance in the delay or prevention of CCVDs. Here, we review the direct assessment of vascular aging by examining parameters that reflect changes in structure, function, or their compliance with age including arterial wall thickness and lumen diameter, endothelium-dependent vasodilation, arterial stiffness as well as indirect assessment through pathological studies of biomarkers including endothelial progenitor cell, lymphocytic telomeres, advanced glycation end-products, and C-reactive protein. Further, we evaluate how different types of interventions including lifestyle mediation, such as caloric restriction and salt intake, and treatments for hypertension, diabetes, and hyperlipidemia affect age-related vascular changes. As a single parameter or intervention targets only a certain vascular physiological change, it is recommended to use multiple parameters to evaluate and design intervention approaches accordingly to prevent systemic vascular aging in clinical practices or population-based studies.

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Assessment of Carotid Arterial Stiffness in Community Settings With ARTSENS®

Cited by 28 publications

References 40 publications

Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians

Vascular Aging: Assessment and Intervention

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