Local production of rotavirus specific IgA in breast tissue and transfer to neonates.

Rahman, Mustafizur; Yamauchi, Masashi; Hanada, Naoki; Nishikawa, Kiyonobu; Morishima, Tsuneo

doi:10.1136/adc.62.4.401

Cited by 22 publications

(10 citation statements)

References 11 publications

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“…This fluctuation in antibody response has been observed by others and explained by maternal contact with the infected infant, with no induction of diarrhoea in the mother (18). Rahman et al (20) reported that anti-rotavirus antibodies are produced locally in the mammary gland after antigenic GALT stimulation. However, rotavirus infection can still occur in breast-fed infants despite the presence of these antibodies in maternal milk, although the symptoms have been shown to be less intense (21).…”

Section: Resultssupporting

confidence: 66%

Immunological factors in milk from Brazilian mothers delivering small‐for‐date term neonates

et al. 1993

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Breast milk samples from three groups of Brazilian women were evaluated: G1, mothers delivering term babies of low birth weight (n = 16); G2, mothers delivering preterm babies of appropriate birth weight (n = 20); G3, mothers delivering term babies of appropriate birth weight (n = 30). Milk samples were obtained at 48 h and on the 7th, 15th, 30th and 60th days after delivery and they were analyzed for lysozyme and total IgA levels and for the presence of specific antibodies against Poliovirus types I, II, III, Rotavirus, Herpes simplex virus, Varicella zoster and Cytomegalovirus. The groups were not statistically different in relation to mother's age, parity, type of delivery or socio-economic levels. IgA levels were higher in both low-birth-weight groups (G1 & G2) compared to the control group (G3) throughout the study period. Lysozyme levels decreased up to the 15th day, increasing thereafter up to the 60th day in all groups. Specific antibodies were detected throughout the study period, with no differences among groups. We conclude that breast milk composition of mothers delivering low-birth-weight babies (G1 & G2) was similar despite the different gestational ages.

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Section: Resultssupporting

confidence: 66%

Immunological factors in milk from Brazilian mothers delivering small‐for‐date term neonates

et al. 1993

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“…Similarly, the HIV Env-specific antibody response in milk of HIV-infected lactating women is predominantly IgG (17,61). In contrast, the milk antibody response against other viral pathogens such as rotavirus and respiratory syncytial virus has been reported to be predominantly IgA (62,63). Previous HIV/SIV immunization studies have reported higher IgG than IgA antibody responses in mucosal compartments (64)(65)(66).…”

Section: Discussionmentioning

confidence: 74%

Mucosal Immunization of Lactating Female Rhesus Monkeys with a Transmitted/Founder HIV-1 Envelope Induces Strong Env-Specific IgA Antibody Responses in Breast Milk

Fouda¹,

Amos²,

Wilks

et al. 2013

J Virol

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“… 35,36 By contrast, the minimal number of rotavirus diarrhea cases observed in infants at the age of less than 1–5 months might possibly be due to maternal immunity and non‐specific factors contained in colostrum and breast milk that provide some protection against rotavirus infection. 37,38 …”

Section: Resultsmentioning

confidence: 99%

Epidemiology of rotavirus infection in Thailand

Maneekarn

Ushijima

2000

Pediatrics International

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Rotavirus is a major cause of acute severe diarrhea in children worldwide and an important cause of death among young children in developing countries. Group A rotaviruses are antigenically complex and multiple serotypes infect humans. Reassortant rotavirus vaccines are now available which offer protection against severe illness caused by rotavirus serotypes G1-4. Before vaccines are introduced into target populations, it is necessary to establish the baseline data of the epidemiology of rotavirus infection in those countries. The purpose of the present study is to provide information related to the epidemiology of rotavirus infection in Thailand. All rotavirus studies performed in Thailand were found through Medline and Thai Index Medicus searches. A total of 26 of the most relevant studies published in international and national journals are reviewed. Most studies reported that the prevalence of rotavirus infection in Thailand was 27-34%, although a few studies have reported a prevalence above this range. The peak seasonal distribution of rotavirus infection among children hospitalized with diarrhea in Thailand was seen in the dry cool seasons: October to February. The prevalence of rotavirus infection was most frequently found in children aged 6-11 months up to 2 years. G1 was the most prevalent serotype in Thailand, followed by G2, G4 and G3, respectively. At least three G serotypes, mostly G1, G2 and G4, are seen to coexist in Thailand each epidemic year and in some studies all four G-serotypes were reported in the same epidemics. In a 1996-1997 study, G9 was the third prevailing serotype after G1 and G2, respectively. These results indicate that rotavirus epidemics occur in Thailand every year and children are the most affected population. In Thailand, although G1-G4 have been reported, G1 is the most prevalent serotype in each epidemic and G9 is becoming increasingly common.

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Local production of rotavirus specific IgA in breast tissue and transfer to neonates.

Cited by 22 publications

References 11 publications

Immunological factors in milk from Brazilian mothers delivering small‐for‐date term neonates

Immunological factors in milk from Brazilian mothers delivering small‐for‐date term neonates

Mucosal Immunization of Lactating Female Rhesus Monkeys with a Transmitted/Founder HIV-1 Envelope Induces Strong Env-Specific IgA Antibody Responses in Breast Milk

Epidemiology of rotavirus infection in Thailand

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