Local oral and nasal microbiome diversity in age-related macular degeneration

Rullo, Jacob; Far, Parsa Mehraban; Quinn, Matthew P.; Sharma, Neel; Bae, Steven S.; Irrcher, Isabella; Sharma, Sanjay

doi:10.1038/s41598-020-60674-3

Cited by 19 publications

(19 citation statements)

References 26 publications

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“…In the oral microbiota, communities of Propionibacteriales, Rothia, Staphylococcus, and Cornyebacteriaceae were higher in patients with AMD over controls, while Fusobacterium and Bacilli were higher in controls over cases [30]. Gemella and Streptococcus were also found to be more abundant in the pharyngeal microbiome of AMD patients compared to healthy controls in a recent study by Ho et al [31], while Prevotella and Leptotrichia were reported to have an opposite trend, being higher in controls.…”

Section: Nasal Oral Pharyngeal and Intestinal Microbiota In Amd Patientsmentioning

confidence: 91%

Section: Nasal Oral Pharyngeal and Intestinal Microbiota In Amd Patientsmentioning

confidence: 99%

“…When comparing the microbiome of AMD patients to that of healthy controls, several studies reported notable differences [26,[30][31][32]. As far as the nasal and oral mi-DOI: 10.1159/000515026 crobial communities are concerned, Rullo et al [30] found statistically significant differences between cases of neovascular AMD and healthy controls. Specifically, in the nasal microbial communities, Streptococcus, Burkholderiales, Actinomycetaceae, Gemella, Proteobacteria, Actinomyces, and Veillonella were all found to be significantly increased in AMD patients over controls, while members of the Clostridia class were enriched in controls [30].…”

Section: Nasal Oral Pharyngeal and Intestinal Microbiota In Amd Patientsmentioning

confidence: 99%

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The Role of the Microbiome in Age-Related Macular Degeneration: A Review of the Literature

et al. 2021

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Background: Age-related macular degeneration (AMD) is a progressive, multifactorial, degenerative disease and the leading cause of severe visual loss in the elderly population. The exact pathogenesis of AMD remains elusive, being the combination of genetic, environmental, metabolic and functional processes. Better understanding of the disease’s pathophysiology leads to new treatment targets. Human microbiome seems to be a potential therapeutic pathway for AMD, as it has been recently proven to play a role in its pathogenesis. Summary: This review shed light into the association between microbiome and AMD. Key messages: The current evidence based on the existing literature shows that there are differences in taxonomical and functional profiles in human microbiome between patients with AMD and controls, suggesting that microbiome is implicated in AMD onset and progression, being a link between AMD and nutrition/diet. Additionally, specific bacterial classes have been proposed as potential biomarkers for AMD diagnosis. Further randomized clinical studies with large sample are needed to elucidate the role of microbiome in AMD and to draw more solid conclusions.

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Section: Nasal Oral Pharyngeal and Intestinal Microbiota In Amd Patientsmentioning

confidence: 91%

Section: Nasal Oral Pharyngeal and Intestinal Microbiota In Amd Patientsmentioning

confidence: 99%

Section: Nasal Oral Pharyngeal and Intestinal Microbiota In Amd Patientsmentioning

confidence: 99%

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The Role of the Microbiome in Age-Related Macular Degeneration: A Review of the Literature

et al. 2021

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“…Indeed, several studies have linked commensal microbiota to AMD pathogenesis. Patients with AMD have shown distinct intestinal, oral, nasal, and pharyngeal microbial communities, highlighting potential role of mucosal surface microbes in the pathogenesis of AMD (80)(81)(82). Mice fed a high-glycemic diet developed hallmarks of AMD, such as retinal pigment epithelium (RPE) hypopigmentation and atrophy, lipofuscin accumulation, and photoreceptor degeneration, whereas mice fed the lower-glycemia diet did no (83,84).…”

Section: Ocular Inflammatory Diseases Are Associated With Non-ocular mentioning

confidence: 99%

Ocular Microbiota and Intraocular Inflammation

Wei

2020

Front. Immunol.

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The term ocular microbiota refers to all types of commensal and pathogenic microorganisms present on or in the eye. The ocular surface is continuously exposed to the environment and harbors various commensals. Commensal microbes have been demonstrated to regulate host metabolism, development of immune system, and host defense against pathogen invasion. An unbalanced microbiota could lead to pathogenic microbial overgrowth and cause local or systemic inflammation. The specific antigens that irritate the deleterious immune responses in various inflammatory eye diseases remain obscure, while recent evidence implies a microbial etiology of these illnesses. The purpose of this review is to provide an overview of the literature on ocular microbiota and the role of commensal microbes in several eye diseases. In addition, this review will also discuss the interaction between microbial pathogens and host factors involved in intraocular inflammation, and evaluate therapeutic potential of targeting ocular microbiota to treat intraocular inflammation.

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“…Still, early signs of the disease can appear when people are in their 50s [7]. The particular pathophysiology of AMD is not clear, so this ocular impairment is described as a multifactorial disease because of its associations with environmental [8,9] and genetic factors [10], metabolite profile [11], and even microbiome [12] changes. Increasing age, female gender, and ethnicity with the highest prevalence in Europeans at 12.3-30% have also been pinpointed as relevant risk factors [13,14].…”

Section: Introductionmentioning

confidence: 99%

IL-9 and IL-10 Single-Nucleotide Variants and Serum Levels in Age-Related Macular Degeneration in the Caucasian Population

Vilkeviciute

Čebatorienė

Kriauciuniene

et al. 2021

Mediators of Inflammation

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Considering the immunological impairment in age-related macular degeneration (AMD), we aimed to determine the associations of IL-9 rs1859430, rs2069870, rs11741137, rs2069885, and rs2069884 and IL-10 rs1800871, rs1800872, and rs1800896 polymorphisms and their haplotypes, as well as the serum levels of IL-9 and IL-10 with AMD. 1209 participants were enrolled in our study. SNPs were genotyped using TaqMan SNP genotyping assays by real-time PCR method. IL-9 and IL-10 serum levels were evaluated using ELISA kits. Our study results have shown that haplotypes A-G-C-G-G and G-A-T-A-T of IL-9 SNPs are associated with the decreased odds of early AMD occurrence ( p = 0.035 and p = 0.015 , respectively). A set of rare haplotypes was associated with the decreased odds of exudative AMD occurrence ( p = 0.033 ). Also, IL-10 serum levels were lower in exudative AMD than in controls ( p = 0.049 ), patients with early AMD ( p = 0.017 ), and atrophic AMD ( p = 0.008 ). Furthermore, exudative AMD patients with IL-10 rs1800896 CT and TT genotypes had lower IL-10 serum concentrations than those with wild-type (CC) genotype ( p = 0.048 ). In conclusion, our study suggests that IL-10 serum levels can be associated with a minor allele at IL-10 rs1800896 and exudative AMD. The haplotypes of IL-9 SNPs were also associated with the decreased odds of early and exudative AMD.

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Local oral and nasal microbiome diversity in age-related macular degeneration

Cited by 19 publications

References 26 publications

The Role of the Microbiome in Age-Related Macular Degeneration: A Review of the Literature

The Role of the Microbiome in Age-Related Macular Degeneration: A Review of the Literature

Ocular Microbiota and Intraocular Inflammation

IL-9 and IL-10 Single-Nucleotide Variants and Serum Levels in Age-Related Macular Degeneration in the Caucasian Population

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