Local manganese chloride treatment accelerates fracture healing in a rat model

Hreha, Jeremy; Wey, Aaron; Cunningham, Catherine; Krell, Ethan S.; Brietbart, Eric A.; Paglia, David N.; Montemurro, Nicholas J.; Nguyen, Daniel A.; Lee, Yung-Jae; Komlos, Daniel; Lim, Elisha; Benevenia, Joseph; O’Connor, J. P.; Lin, Sheldon S.

doi:10.1002/jor.22733

Cited by 23 publications

(8 citation statements)

References 35 publications

(60 reference statements)

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“…Manganese is associated with the maintenance of the bone structure and regulating bone metabolism. An accelerated bone fracture healing was observed in a rat model after being administered with local treatment of Mn 2+ [ 256 , 257 ]. These elements can be carefully chosen by considering their level of toxicity in the human body and their metallurgical role in forming an alloy's microstructure and dictating mechanical properties and degradation behavior.…”

Section: Activating Magnesium With Bioactive Agentsmentioning

confidence: 99%

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Sarian

Iqbal

Sotoudehbagha

et al. 2022

Bioactive Materials

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Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants. The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled. Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture. In this review, a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process. The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction. Hydroxyapatite, collagen type I, recombinant human bone morphogenetic proteins 2, simvastatin, zoledronate, and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants. In addition to coating, the substrate itself can be made bioactive by alloying magnesium with calcium, zinc, copper, and manganese that were found to promote bone regeneration.

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Section: Activating Magnesium With Bioactive Agentsmentioning

confidence: 99%

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Sarian

Iqbal

Sotoudehbagha

et al. 2022

Bioactive Materials

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“…In fact, a group reported a significant increase in the mechanical properties of bone, mineralized tissue formation and VEGF-expression in a rat femoral fracture model when manganese chloride (MnCl 2 ) was supplemented. Additionally, blood vessel density was dramatically increased by MnCl 2 treatment, suggesting increased vascularization, fracture healing and osteogenesis, implicating a potential function for manganese in tissue engineering [ 238 ].…”

Section: Metal Ions Their Physiological Functionalities and Role mentioning

confidence: 99%

Applications of Metals for Bone Regeneration

Glenske

Donkiewicz²,

Köwitsch³

et al. 2018

IJMS

165

116

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The regeneration of bone tissue is the main purpose of most therapies in dental medicine. For bone regeneration, calcium phosphate (CaP)-based substitute materials based on natural (allo- and xenografts) and synthetic origins (alloplastic materials) are applied for guiding the regeneration processes. The optimal bone substitute has to act as a substrate for bone ingrowth into a defect, as well as resorb in the time frame needed for complete regeneration up to the condition of restitution ad integrum. In this context, the modes of action of CaP-based substitute materials have been frequently investigated, where it has been shown that such materials strongly influence regenerative processes such as osteoblast growth or differentiation and also osteoclastic resorption due to different physicochemical properties of the materials. However, the material characteristics needed for the required ratio between new bone tissue formation and material degradation has not been found, until now. The addition of different substances such as collagen or growth factors and also of different cell types has already been tested but did not allow for sufficient or prompt application. Moreover, metals or metal ions are used differently as a basis or as supplement for different materials in the field of bone regeneration. Moreover, it has already been shown that different metal ions are integral components of bone tissue, playing functional roles in the physiological cellular environment as well as in the course of bone healing. The present review focuses on frequently used metals as integral parts of materials designed for bone regeneration, with the aim to provide an overview of currently existing knowledge about the effects of metals in the field of bone regeneration.

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“…Furthermore, local insulin therapy has been found to improve bone healing and cartilage formation in animal models (Dedania et al, ; Gandhi, Beam, O'Connor, Parsons, & Lin, ; Park et al, ). Other insulin mimetics, such as vanadyl acetylacetonate, magnesium chloride, and sodium tungstate, have been shown to improve the osteogenesis of mesenchymal stem cells (MSCs; Schussler et al, ), bone healing (Hreha et al, ) and chondrogenic differentiation (Khader, Sherman, Rameshwar, & Arinzeh, ) respectively. Zinc supplementation in the cell culture medium has been shown to enhance mineralization and osteocalcin gene expression of MC3T3‐E1 osteoblasts (Nagata & Lonnerdal, ).…”

Section: Introductionmentioning

confidence: 99%

Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells

Khader

Arinzeh

2019

Biotech & Bioengineering

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Osteoarthritis (OA) involves the degeneration of articular cartilage and subchondral bone. The capacity of articular cartilage to repair and regenerate is limited. A biodegradable, fibrous scaffold containing zinc oxide (ZnO) was fabricated and evaluated for osteochondral tissue engineering applications. ZnO has shown promise for a variety of biomedical applications but has had limited use in tissue engineering. Composite scaffolds consisted of ZnO nanoparticles embedded in slow degrading, polycaprolactone to allow for dissolution of zinc ions over time. Zinc has well‐known insulin‐mimetic properties and can be beneficial for cartilage and bone regeneration. Fibrous ZnO composite scaffolds, having varying concentrations of 1–10 wt.% ZnO, were fabricated using the electrospinning technique and evaluated for human mesenchymal stem cell (MSC) differentiation along chondrocyte and osteoblast lineages. Slow release of the zinc was observed for all ZnO composite scaffolds. MSC chondrogenic differentiation was promoted on low percentage ZnO composite scaffolds as indicated by the highest collagen type II production and expression of cartilage‐specific genes, while osteogenic differentiation was promoted on high percentage ZnO composite scaffolds as indicated by the highest alkaline phosphatase activity, collagen production, and expression of bone‐specific genes. This study demonstrates the feasibility of ZnO‐containing composites as a potential scaffold for osteochondral tissue engineering.

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Local manganese chloride treatment accelerates fracture healing in a rat model

Cited by 23 publications

References 35 publications

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Potential bioactive coating system for high-performance absorbable magnesium bone implants

Applications of Metals for Bone Regeneration

Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells

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