Local invasion of hepatic alveolar echinococcosis should not be underestimated: Lessons learned from imaging-pathologic correlation

Calame, Paul; Doussot, Alexandre; Turco, Célia; Colpart, Prudence; Heyd, Bruno; Delabrousse, Éric

doi:10.1016/j.diii.2021.01.002

Cited by 6 publications

(7 citation statements)

References 7 publications

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“…Even an incomplete resection should be aimed for if, for example, cholestasis can be remedied, a melted-in echinococcosis focus can be rehabilitated, or pressure and pain can be relieved in the case of extensive findings. Liver (re)transplantation in patients with advanced hepatic disease without extrahepatic manifestations is considered a last resort but is rarely performed [ 35 , 36 , 37 ].…”

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

“…In all cases, therapy is initially carried out with an anthelmintic, i.e., with preparation of benzimidazoles, e.g., albendazole. Purely medicinal therapy with albendazole is indicated for patients with inoperable cysts in the liver, multi-organ involvement, or peritoneal cysts [ 35 , 40 , 41 ]. Smaller cysts (<5 cm) respond particularly well.…”

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

“…Since hydatid of the liver cannot be cured with medication in most patients, an interventional or surgical approach is an important strategy, even if these methods can involve complications. In both cases, neoadjuvant treatment with an anthelmintic is mandatory to sterilize the cyst and minimize the risk of anaphylaxis during the procedure [ 35 ]. A maximum of three cycles (every 28 days with a 14-day break) is usually recommended [ 42 ].…”

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

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Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

Hager

Sergi

2023

Diagnostics

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Echinococcosis is considered a neglected disease in most European countries. However, migratory flows of populations, long-term stays in endemic areas, uninterrupted tourism (travel to Echinococcus-endemic countries), traveling dogs and dog translocations from endemic areas, and inappropriate hygiene practices are potential factors that alarm public health officials. Identifying a cyst-like mass in the liver or lung of an individual with a travel history of likely exposure to sheepdogs in an area where the parasite Echinococcus (E.) granulosus (sive cysticus) is endemic advocates for a prompt preliminary diagnosis of cystic echinococcosis (CE), no matter the age of the affected individuals. Routine imaging techniques, including ultrasonography, computed tomography (CT) scans, and magnetic resonance imaging (MRI) scans, are used to detect cysts. After a cyst has been discovered, serologic investigations are used to confirm the diagnosis. Typically, alveolar echinococcosis (AE) is found in older individuals. Yet young people are also affected because frequent oral exploration of the environment is a regular behavior for infants and toddlers. In this review, therapeutic considerations for pediatric echinococcosis—drug-based benzimidazole therapy; AE: atypical liver resection, the resection of individual or multiple segments, a right or left hemi-hepatectomy, or an extended hemi-hepatectomy; CE: PAIR-technique, cyst excision, liver segment(s) resection (laparoscopically or conventionally)—are revised following experience in one of the most affected regions of Europe. In addition, we performed a systematic review using three databases (i.e., PubMed, EMBASE, and Scopus) to evaluate the quality of evidence in published studies on pediatric echinococcosis.

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Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

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Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

Hager

Sergi

2023

Diagnostics

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“…Hepatic alveolar echinococcosis (HAE) is considered to be one of the most deadly chronic parasitic diseases in the world, posing a serious threat to life and health [ 1–4 ]. In humans, AE larvae develop almost exclusively in the liver, leading to slowly progressive, life-threatening tumor-like growth [ 5 , 6 ]. Without treatment, 90–100% of AE patients die 10–15 years after diagnosis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for post-endoscopic retrograde cholangiopancreatography cholangitis in patients with hepatic alveolar echinococcosis—an observational study

Wang

et al. 2022

Annals of Medicine

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“…In humans, metacestodes of AE develop almost exclusively in the liver, inducing slowly progressive, life-threatening tumor-like growths (Brunetti et al 2010;Calame et al 2021). If not treated, 90-100% of AE patients die 10-15 years after diagnosis (Kern et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in ultrasound in the diagnosis and evaluation of the activity of hepatic alveolar echinococcosis

et al. 2021

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Echinococcosis is a worldwide neglected zoonotic disease. Alveolar echinococcosis (AE) poses a more serious threat to life and health than cystic echinococcosis, and has been one of the world's most lethal chronic parasitosis. Assessment of metacestode activity status is essential for individual treatment strategy design for a given AE patient, and fluorodeoxyglucose positron-emission tomography (FDG-PET) has been the gold standard. In this study, we reviewed previous evidence on AE activity assessment using contrast-enhanced ultrasound (CEUS), and its comparison with FDG-PET. The results showed good consistency between them, indicating CEUS as a suitable substitute for FDG-PET. With its advantage as being readily portable, widely available, and not costly, CEUS is more suitable for use in the developing countries and rural areas.

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Local invasion of hepatic alveolar echinococcosis should not be underestimated: Lessons learned from imaging-pathologic correlation

Cited by 6 publications

References 7 publications

Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

Risk factors for post-endoscopic retrograde cholangiopancreatography cholangitis in patients with hepatic alveolar echinococcosis—an observational study

Recent advances in ultrasound in the diagnosis and evaluation of the activity of hepatic alveolar echinococcosis

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