Local injection of corticosteroids for central giant cell granuloma. A case report

Long-term clinical and radiological outcomes of surgical management of central giant cell granuloma of the maxilla

“…Two non-surgical treatment alternatives have been recently introduced for treating CGCG of the maxilla 4,8,11,16,17,[21][22][23] . Firstly, the lesion has been successfully treated by daily subcutaneous injection of calcitonin for at least 1 year in children 8,11,21,22 and even during pregnancy 19 .…”

“…Some authors using calcitonin report no change in the CGCG lesions during the first 4-6 months of treatment 11,21 , while others have reported continued rapid growth during treatment with calcitonin or intralesional corticosteroids 11,13,22 ; recurrence has also been reported after calcitonin therapy and curretage 11,21 . The second alternative treatment is intralesional injection of corticosteroids 4,16,17,23 . The success of this treatment could be related to both inhibition of bone resorption and proliferation and differentiation of osteoclasts 24 .…”

“…However, en bloc resection has been suggested as the treatment of choice for locally aggressive CGCG 5,26 . This type of lesion has also been treated by non-surgical methods, including radiotherapy 5,9 , daily systemic doses of calcitonin 8,11,19 , administration of alpha interferon 14 , and intralesional injection with corticosteroids 4,16,17,23 .…”

Peri-implantitis as a cause of giant-cell granuloma? Presentation of a clinical case

“…Clinical data and therapeutic management of the clinical case reported above correspond to the published data. An intralesional corticosteroid injection could also have been an alternative treatment [10]. However, given the implant mobility and the patient's willingness, surgical solution was preferred.…”

Calcitonin: A non-invasive giant cells therapy

“…Some medical treatments in the literature report the administration of calcitonin and intralesional steroid injections [10][11][12][13]. Harris [13], based on the histologic similarity between CGCG and the ''brown tumor'' of hyperparathyroidism, suggested that CGCG may therefore respond to calcitonin even though there was no biochemical evidence of parathyroid disease.…”