Local Inflammation as a Mediator of Migraine and Tension‐Type Headache

Friedman, Mark H.

doi:10.1111/j.1526-4610.2004.04143.x

Cited by 13 publications

(15 citation statements)

References 16 publications

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“…As local inflammation has been proposed to support migraine pain [17], [18], [19], [20], we sought to investigate if a special phenotype of trigeminal ganglia (responsible for conveying nociceptive signals to the brainstem) consistent with propensity to neuroinflammation might be observed.…”

Section: Discussionmentioning

confidence: 99%

“…Another possibility is that, during a migraine attack, activated macrophages and other non-neuronal cells might induce a meningeal “sterile inflammation” [17], [18], a phenomenon that can contribute to strong headache when associated with local production of inflammatory substances [9], [19]. Furthermore, it has been reported that inflammation in the broad trigeminal nerve territory is often observed during migraine attacks [20] so that acute administration of corticosteroids has been tested to block pain, albeit with mixed results [21]. It is, however, unclear how common these mechanisms are to the various migraine subtypes.…”

Section: Introductionmentioning

confidence: 99%

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TNFα Levels and Macrophages Expression Reflect an Inflammatory Potential of Trigeminal Ganglia in a Mouse Model of Familial Hemiplegic Migraine

et al. 2013

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Latent changes in trigeminal ganglion structure and function resembling inflammatory conditions may predispose to acute attacks of migraine pain. Here, we investigated whether, in trigeminal sensory ganglia, cytokines such as TNFα might contribute to a local inflammatory phenotype of a transgenic knock-in (KI) mouse model of familial hemiplegic migraine type-1 (FHM-1). To this end, macrophage occurrence and cytokine expression in trigeminal ganglia were compared between wild type (WT) and R192Q mutant CaV2.1 Ca2+ channel (R192Q KI) mice, a genetic model of FHM-1. Cellular and molecular characterization was performed using a combination of confocal immunohistochemistry and cytokine assays. With respect to WT, R192Q KI trigeminal ganglia were enriched in activated macrophages as suggested by their morphology and immunoreactivity to the markers Iba1, CD11b, and ED1. R192Q KI trigeminal ganglia constitutively expressed higher mRNA levels of IL1β, IL6, IL10 and TNFα cytokines and the MCP-1 chemokine. Consistent with the report that TNFα is a major factor to sensitize trigeminal ganglia, we observed that, following an inflammatory reaction evoked by LPS injection, TNFα expression and macrophage occurrence were significantly higher in R192Q KI ganglia with respect to WT ganglia. Our data suggest that, in KI trigeminal ganglia, the complex cellular and molecular environment could support a new tissue phenotype compatible with a neuroinflammatory profile. We propose that, in FHM patients, this condition might contribute to trigeminal pain pathophysiology through release of soluble mediators, including TNFα, that may modulate the crosstalk between sensory neurons and resident glia, underlying the process of neuronal sensitisation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TNFα Levels and Macrophages Expression Reflect an Inflammatory Potential of Trigeminal Ganglia in a Mouse Model of Familial Hemiplegic Migraine

et al. 2013

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“…В частности, имеются указания на то, что у больных мигренью повыше-на восприимчивость к инфекциям, а успешное лечение воспалительных заболеваний облегчает течение цефалгии [9]. Показано, что локальные воспалительные процессы в ротовой полости мо-гут ухудшать течение мигрени и головной боли напряжения [18]. Обсуждается роль очагов хро-нической инфекции в верхних отделах дыхатель-ных путей и хронических заболеваний полости носа в развитии сенситизации сенсорных аффе-рентов тройничного нерва [3,27].…”

Section: карпова ми и др медицинская иммунологияunclassified

State of Immune System in Patients With Primary Headaches

Карпова¹,

Simbirtsev²,

Шамуров³

2014

Med.Imm.Rus

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ВведениеАктуальность проблемы. Высокая распростра-ненность первичных головных болей (ПГБ) в по-пуляции, значительное их влияние на качество жизни больных делают диагностику и лечение этих заболеваний актуальной проблемой. К ПГБ относятся мигрень (М), головная боль напря-жения (ГБН), кластерная головная боль (КГБ) и «головные боли, не связанные со структурным повреждением» [8]. Эти заболевания являются самостоятельными нозологическими формами.Последние годы представления о ПГБ пре-терпели значительные изменения. Если раньше благодаря отсутствию макроскопически опре- Адрес для переписки:Карпова Мария Ильинична, ГУО ВПО ЧелГМА Росздрава 454092, г. Челябинск, ул. Воровского, 64. Тел.: (351) 232-73-71. Факс: (351) 260-77-55. Е-mail: kmi_2008@mail.ru Резюме. У больных первичными головными болями выявлена высокая частота встречаемости со-путствующих соматических заболеваний, большой удельный вес среди которых имеют клинические проявления патологии иммунной системы. Ведущими проявлениями иммунной недостаточности у обследованных пациентов были вторичный иммунодефицит и аллергические заболевания. Досто-верные различия в частоте хронических воспалительных и аллергических заболеваний у пациентов с эпизодическими и хроническими первичными головными болями позволяют рассматривать дан-ные состояния как фактор, неблагоприятно влияющий на течение цефалгий. Результаты лаборатор-ного исследования у обследованных больных показали наличие признаков иммунодефицита с из-менением соотношения их субпопуляций, нарушением функциональной активности нейтрофилов, снижением уровня IgG, дисбалансом в системе цитокинов. STATE OF IMMUNE SYSTEM IN PATIENTS WITH PRIMARY HEADACHESAbstract. High incidence of accompanying somatic diseases has been revealed in patients with primary headache syndromes, while clinical manifestations of immune disorders being quite prevalent among them. The most common immune pathology in the studied patients were secondary immune deficiency and allergic diseases. Significant differences in the rates of chronic inflammatory and allergic diseases in patients with episodic and chronic primary headaches allow of considering these conditions as a factor unfavorably affecting clinical course of cephalalgias. The results of laboratory examinations in the studied patients showed presence of immune deficiency features, with changing ratio of immune subpopulations, altered functional activity of neutrophils, decreased IgG levels, and imbalance in cytokine system. (Med. Immunol., vol. 12, N 6, pp 529-536)

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“…15 Indeed, local inflammation may play a role in the pathogenesis of migraine. 16,17 Statins have antiinflammatory properties 14 and, thus, could influence this component. Furthermore, in patients with typical aura with migraine, there is an impairment in the adaptive cerebral hemodynamic mechanisms.…”

Section: Migraine Headache and Statinsmentioning

confidence: 99%

Could Statins Be Useful in the Treatment of Patients With Migraine?

Liberopoulos

Mikhailidis²

2006

Headache

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Migraine is a common and disabling neurological disorder. Studies have shown that patients with migraine (especially those with typical aura with migraine) have an unfavorable cardiovascular risk profile and an increased risk of early-onset (<45 years) ischemic stroke. Statins are effective hypolipidemic drugs that reduce cardiovascular-related morbidity and death in patients with or without established atherosclerotic vascular disease. We report a patient whose frequent attacks of typical aura with migraine completely resolved after the initiation of treatment with a statin. In this context, we comment on the possible effects of statins on the pathophysiology of migraine. We suggest that statins may be useful drugs in the treatment of migraine because they could reduce the increased cardiovascular risk in these patients and also attenuate migraine attacks. Only a randomized prospective study in this population could provide a definite answer to these speculations.

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Local Inflammation as a Mediator of Migraine and Tension‐Type Headache

Abstract: These results suggest that a local intraoral inflammation may be associated with the pathogenesis of these common headaches.

Cited by 13 publications

References 16 publications

TNFα Levels and Macrophages Expression Reflect an Inflammatory Potential of Trigeminal Ganglia in a Mouse Model of Familial Hemiplegic Migraine

TNFα Levels and Macrophages Expression Reflect an Inflammatory Potential of Trigeminal Ganglia in a Mouse Model of Familial Hemiplegic Migraine

State of Immune System in Patients With Primary Headaches

Could Statins Be Useful in the Treatment of Patients With Migraine?

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