Local infiltration of Vitamin D<sub>3</sub>does not accelerate orthodontic tooth movement in humans:<i>A preliminary study</i>

Shetty, Abhijith; Patil, Anand; Ameet, R; Sandhu, Prabhdeep Kaur

doi:10.2319/122214-935.1

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…However, Shetty et al 36 showed in 2015 that local injection of vitamin D3 can significantly reduce the rate and amount of tooth movement in humans after a 60-day trial period, contradicting previous results.…”

Section: Discussionmentioning

confidence: 88%

“…2,33 Vitamin D deficiency can lead to skeletal disorders such as osteomalacia as well as non-skeletal effects such as secondary hyperparathyroidism 34,35 A study in 2011 showed that local injection of 1,25,2(OH) D3 was clinically effective in increasing the rate of OTM in humans, and it was demonstrated to be dose-dependent. 30 However, Shetty et al 36 reported in 2015 that local injections of vitamin D3 significantly reduced the rate and amount of tooth movement in humans. According to a study, 1,25,2(OH)D3 stimulates osteoclastic bone resorption through a primary hormonal response in osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

Farzanegan

Nour

Mobarhan

et al. 2023

Journal of Advanced Oral Research

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Aim: One of the problems that orthodontists commonly face is the prolonged duration of the treatment. Therefore, it is important to find an effective method to increase the rate of orthodontic tooth movement (OTM). This study aimed to evaluate the effectiveness of oral administration of vitamin D3 on OTM rates in humans. Materials and Methods: In this randomized clinical trial study, we selected 29 healthy women aged 18–25 years who sought orthodontic treatment and required bilateral maxillary first premolar extraction. Participants were tested to measure the blood levels of vitamin D3 and, based on the outcomes, were divided into three groups: control (without vitamin D3 deficiency; N = 10), placebo ( N = 9), and experiment ( N = 10), both with vitamin D3 deficiency. Subjects of the last two groups, who were randomly assigned, received 50,000 IU (International Unit) vitamin D3 pearls (Dana Pharmaceutical Company, Tabriz, Iran) or a placebo every 2 weeks for 2 months. Inclusion criteria were patients requiring bilateral extraction of the first premolar in the maxilla. The canines were retracted by nickel-titanium (NiTi) coil springs into the extraction sites. At the beginning, after 1 and 2 months, the distance between canine and lateral teeth on both sides was measured to calculate OTM. Results: In the first month ( t (1–2)), the mean values of OTM in the placebo group were higher than the other groups. However, during the second month ( t (2–3)) and overall ( t (1–3)), the experiment group showed a higher OTM. The experiment and control groups were statistically different in all three time periods ( P-value < .05). The difference between the experiment and placebo groups was only significant in t (2–3) ( P-value < .05). Whereas the placebo and control groups showed a significant difference in t (1–2) ( P-value < .05). Conclusion: Vitamin D3 deficiency seems to increase OTM. Receiving oral supplements of vitamin D3 may not have much effect on increasing the level of vitamin D3. The lowest OTM rate was observed in the control group.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

Farzanegan

Nour

Mobarhan

et al. 2023

Journal of Advanced Oral Research

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“…En contraposición a lo anterior afirmado, un ECA en donde las encías de los dientes experimentales recibieron inyecciones localizadas de vitamina D3, determino que los dientes experimentales se movieron mucho menos que los dientes de control, después de un período experimental de 60 días. (Shetty et al, 2015) • La relaxina (HRH)…”

Section: • Plasma Rico En Plaquetas (Prp)unclassified

“…El 1,25-dihidroxicolecalciferol o calcitriol hay opiniones contrapuestas, por un lado, estudios (Varughese et al, 2019) (Iosub et al, 2016) (Kouskoura et al, 2017) coinciden que este metabolito de la vitamina d puede ser eficaz para acelerar MOD. Por otro lado, un estudio determino que los dientes experimentales se movieron mucho menos que los dientes de control (Shetty et al, 2015). En una R.S.…”

Section: • Plasma Rico En Plaquetas (Prp)unclassified

Terapias no quirúrgicas que aceleran el movimiento ortodontico en humanos. Revisión de literatura.

Berru

Hidalgo

2023

MQRInvestigar

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Acelerar la tasa de movimiento dental puede ayudar a reducir la duración del tratamiento de ortodoncia y los efectos secundarios debido al largo uso de aparatos ortodónticos, existen varios métodos complementarios quirúrgicos y no quirúrgicos, para acelerar el movimiento de los dientes. El objetivo de esta revisión fue evaluar la evidencia disponible sobre la efectividad del movimiento ortodóntico acelerado de los dientes a través de abordajes complementarios no quirúrgicos en humanos y sus mecanismos biológicos. Se realizó una búsqueda en la literatura, las bases de datos electrónicas consultadas incluyeron los motores de búsqueda: Pubmed, Cochrane Library, Google Academic, Web of Science y Springer. La búsqueda de información se realizó desde enero del 2013 a enero del 2023 sin límite de idioma. Se obtubieron 393 artículos, luego de aplicar los filtros y criterios de inclusión y exclusión se establecieron 63 artículos para realizar esta revisión. La literatura disponible reveló que existe un nivel de evidencia de moderada a baja con respecto a la terapia láser de baja intensidad y la efectividad en la aceleración del movimiento dental ortodóntico, por otra parte, el nivel de evidencia es limitado en la fotobiomodulación, vibración, ultrasonido y en el uso de fármacos.

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Effect of vitamin D on bone morphometry and stability of orthodontic tooth movement in rats

Gratton¹,

Londono²,

Rompré³

et al. 2022

American Journal of Orthodontics and Dentofacial Orthopedics

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Local infiltration of Vitamin D₃does not accelerate orthodontic tooth movement in humans:A preliminary study

Cited by 7 publications

References 22 publications

Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

Terapias no quirúrgicas que aceleran el movimiento ortodontico en humanos. Revisión de literatura.

Effect of vitamin D on bone morphometry and stability of orthodontic tooth movement in rats

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Local infiltration of Vitamin D3does not accelerate orthodontic tooth movement in humans:A preliminary study

Cited by 7 publications

References 22 publications

Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

Evaluation of the Effect of Oral Vitamin D3 Supplement on Orthodontic Tooth Movement: A Randomized Clinical Trial Study

Terapias no quirúrgicas que aceleran el movimiento ortodontico en humanos. Revisión de literatura.

Effect of vitamin D on bone morphometry and stability of orthodontic tooth movement in rats

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Local infiltration of Vitamin D₃does not accelerate orthodontic tooth movement in humans:A preliminary study