Local increase of steroid hormone concentrations in blood supplying the uterus and oviduct in anaesthetized and conscious gilts

Stefańczyk-Krzymowska, Stanisława; Skipor, Janina; Grzegorzewski, Waldemar; Wąsowska, Barbara; Krzymowski, T

doi:10.1016/0378-4320(94)01323-3

Cited by 26 publications

(26 citation statements)

References 2 publications

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“…All experiments done after the male effect measured plasma P4 concentrations in the jugular vein, but it is known in various species that it is much lower than that of the uterine and ovarian arteries (2.35 times lower in humans [36], sows [37,38], review [39]). Thus it is very probable that the small difference at day 4 between females which will experience a short cycle and females which will experience a normal one are dramatically amplified in the blood supplying the uterus and the ovary itself.…”

Section: Importance Of the CL Characteristics Issued From Male-inducementioning

confidence: 99%

Male-induced short oestrous and ovarian cycles in sheep and goats: a working hypothesis

et al. 2006

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-The existence of short ovulatory cycles (5-day duration) after the first male-induced ovulations in anovulatory ewes and goats, associated or not with the appearance of oestrous behaviour, is the origin of the two-peak abnormal distribution of parturitions after the "male effect". We propose here a working hypothesis to explain the presence of these short cycles. The male-effect is efficient during anoestrus, when follicles contain granulosa cells of lower quality than during the breeding season. They generate corpora lutea (CL) with a lower proportion of large luteal cells compared to small cells, which secrete less progesterone, compared to what is observed in the breeding season cycle. This is probably not sufficient to block prostaglandin synthesis in the endometrial cells of the uterus at the time when the responsiveness to prostaglandins of the new-formed CL is initiated and, in parallel, to centrally reduce LH pulsatility. This LH pulsatility stimulates a new wave of follicles secreting oestradiol which, in turn, stimulates prostaglandin synthesis and provokes luteolysis and new ovulation(s). The occurrence of a new follicular wave on days 3-4 of the first male-induced cycle and the initiation of the responsiveness to prostaglandins of the CL from day 3 of the oestrous cycle are probably the key elements which ensure such regularity in the duration of the short cycles. Exogenous progesterone injection suppresses short cycles, probably not by delaying ovulation time, but rather by blocking prostaglandin synthesis, thus impairing luteolysis. The existence, or not, of oestrous behaviour associated to these ovulatory events mainly varies with species: ewes, compared to does, require a more intense endogenous progesterone priming; only ovulations preceded by normal cycles are associated with oestrous behaviour. Thus, the precise and delicate mechanism underlying the existence of short ovulatory and oestrous cycles induced by the male effect appears to be dependent on the various levels of the hypothalamo-pituitary-ovario-uterine axis.male-effect / ovulation / corpus luteum / cycle / oestrus / uterus

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Section: Importance Of the CL Characteristics Issued From Male-inducementioning

confidence: 99%

Male-induced short oestrous and ovarian cycles in sheep and goats: a working hypothesis

et al. 2006

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“…A local increase of steroid-hormone concentration has been observed in blood supplying the uterus and oviduct in anesthetized and conscious gilts (Stefańczyk- Krzymowska et al 1994) and on days 17-18 of the estrous cycle of gilts (Stefańczyk-Krzymowska et al 1998). Moreover, adrenoreceptors of the ovarian vascular pedicle appear to be involved in the regulation of the countercurrent transfer of these hormones (Stefańczyk-Krzymowska et al 1997).…”

Section: Discussionmentioning

confidence: 93%

Morphological analysis of transportation pathways of microspheres after their introduction into the uterine horn cavity in cyclic pigs

Doboszyńska

Andronowska

2004

Cell Tissue Res

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Countercurrent transfer is thought to be one of the most important mechanisms involved in the transfer of substances between the uterus and oviduct. The present study was aimed at recognizing other putative transportation pathways from the uterine cavity through the oviduct onto the surface of and into internal ovarian structures. Microspheres (latex beads, 0.8 microm in diameter) were introduced into the uterine horn cavity of pigs, for 30 min, at various days of the estrous cycle. The transportation pathways of the beads were then analyzed by light and electron microscopy. The transport of microspheres through the oviduct canal into ovarian tissues took place on each day of the estrous cycle. The largest numbers of microspheres passed through the tunica albuginea to the corpora lutea. Some of microspheres also reached the surface of the uterine ligament through the oviduct canal, where they attained the lumen of blood and lymphatic vessels, mainly of the vascular subovarian (VSP) and paraovarian lymphatic plexus (PLP), via the lymphatic stomata pathway. Transport of microspheres also took place simultaneously through the uterine and oviduct walls and from particular organs through blood and lymphatic vessels. Although the present results do not exclude the participation of countercurrent transfer between venous, lymphatic, and arterial vessels, they provide morphological evidence for the presence of direct transportation pathways of substances, released into the uterine lumen, into ovarian tissues through the oviduct canal.

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“…The factors affecting the tension of the blood vessels changes the condition of blood circulation in the mesovarium and mesometrium, blood vessel permeability and the creation and flow of the lymph. Thus, they may influence processes conditioning local delivery of ovarian hormones to the uterus (Stefańczyk-Krzymowska et al 1994) and uterine PGs to the ovary (Heap et al 1985, 1989, Chłopek et al 2008. It has been earlier demonstrated that blocking of α1-adrenoreceptors affected the local destination transfer of steroid hormones to the uterus (Stefańczyk-Krzymowska et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Contractile effect of PGF2α and PGE2 on isolated branches of uterine and ovarian artery in different days of estrous cycle and early pregnancy in pigs

Skipor¹,

Pikulińska²,

Stefańczyk-Krzymowska³

2010

Polish Journal of Veterinary Sciences

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The contractile effects of PGF 2 α (3 × 10 -6 to 10 -4 M) and PGE 2 (10 -7 to 10 -5 M) were examined on isolated branches of ovarian artery (OA) and extramyometrial branches of uterine artery (UA) collected from pigs in the luteal (day 10-12) and follicular phase (day 17-20) of the estrous cycle, and during early pregnancy (day 10-12). Strong contraction was demonstrated in both arteries during all investigated periods in response to PGF 2 α, which was significantly higher (P < 0.01) than to PGE 2 , being negligible in the follicular phase. In UA, the effective dose of PGF 2 α (ED 50 ) amounted 7.9 × 10 -6 M and 6.3 × 10 -6 M in the luteal and follicular phase, and 5.0 × 10 -6 M in early pregnancy. ED 50 for PGE 2 reached 5.0 × 10 -7 M in the luteal phase, and 4.1 × 10 -7 M in early pregnancy. For both prostaglandins, the contraction was much stronger (P < 0.01) in OA than in UA branches. In OA, the ED 50 for PGF 2 α was 1.2 × 10 -5 M in the luteal phase and was significantly higher (P < 0.05) than in the follicular phase (3.1 × 10 -6 M) and early pregnancy (2.7 × 10 -6 M). ED 50for PGE 2 amounted 7.3 × 10 -7 M in the luteal phase and 1.7 × 10 -7 M in early pregnancy. Studies showed the influence of the estrous cycle and early pregnancy on OA branches sensitivity to the contractile effect of PGF 2 α and the lack of this effect on UA branches, and the influence of the estrous cycle on UA and OA branch contraction in response to PGE 2 .

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Local increase of steroid hormone concentrations in blood supplying the uterus and oviduct in anaesthetized and conscious gilts

Cited by 26 publications

References 2 publications

Male-induced short oestrous and ovarian cycles in sheep and goats: a working hypothesis

Male-induced short oestrous and ovarian cycles in sheep and goats: a working hypothesis

Morphological analysis of transportation pathways of microspheres after their introduction into the uterine horn cavity in cyclic pigs

Contractile effect of PGF2α and PGE2 on isolated branches of uterine and ovarian artery in different days of estrous cycle and early pregnancy in pigs

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