The contractile effects of PGF 2 α (3 × 10 -6 to 10 -4 M) and PGE 2 (10 -7 to 10 -5 M) were examined on isolated branches of ovarian artery (OA) and extramyometrial branches of uterine artery (UA) collected from pigs in the luteal (day 10-12) and follicular phase (day 17-20) of the estrous cycle, and during early pregnancy (day 10-12). Strong contraction was demonstrated in both arteries during all investigated periods in response to PGF 2 α, which was significantly higher (P < 0.01) than to PGE 2 , being negligible in the follicular phase. In UA, the effective dose of PGF 2 α (ED 50 ) amounted 7.9 × 10 -6 M and 6.3 × 10 -6 M in the luteal and follicular phase, and 5.0 × 10 -6 M in early pregnancy. ED 50 for PGE 2 reached 5.0 × 10 -7 M in the luteal phase, and 4.1 × 10 -7 M in early pregnancy. For both prostaglandins, the contraction was much stronger (P < 0.01) in OA than in UA branches. In OA, the ED 50 for PGF 2 α was 1.2 × 10 -5 M in the luteal phase and was significantly higher (P < 0.05) than in the follicular phase (3.1 × 10 -6 M) and early pregnancy (2.7 × 10 -6 M). ED 50for PGE 2 amounted 7.3 × 10 -7 M in the luteal phase and 1.7 × 10 -7 M in early pregnancy. Studies showed the influence of the estrous cycle and early pregnancy on OA branches sensitivity to the contractile effect of PGF 2 α and the lack of this effect on UA branches, and the influence of the estrous cycle on UA and OA branch contraction in response to PGE 2 .
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