Local endometrial scratching under ultrasound-guidance after failed intrauterine insemination and cycle outcome: A randomized controlled trial

Investigating the effect of endometrial scratch on the success of IUI cycle

“…This research findings were inconsistent with findings of the studies conducted by A. Barash (1). Given the researcher studies and the limited literature of research, it seems that no study consistent with this study has been conducted so far.…”

“…One of the oldest methods used to treat the infertility is Iui. Intra uterine insemination (IUI) is regarded as one of the most common and known types of artificial insemination, and it is today considered as one of the methods for treatment of infertility with causes, cervical factor, non-ovulation, endometriosis, immunological factor, male infertility, and unknown factor (1). Low levels of unprepared semen fluid was used for intravaginal insemination, but due to the possibility of reaction with proteins, prostaglandins and bacteria available in the semen, and very low success of this method, it is today spoken as historical topic, and washed and prepared sperm rather than semen fluid is nowadays used in IUI (2) and it is used as a non-risky method accepted by majority of physicians and infertility officials (2,3).…”

The effect of endometrial scratch injury on pregnancy outcome in women with previous intrauterine insemination failure: A randomized clinical trial

“…In a similar way, Soliman and Harira evaluated the effect of ESI on fertility outcome, in the mid‐proliferative phase of the same cycle after one previous IUI failure . It was concluded that ESI in the mid‐proliferative phase was associated with increase of pregnancy rate after one IUI failure .…”

“…In a similar way, Soliman and Harira evaluated the effect of ESI on fertility outcome, in the mid‐proliferative phase of the same cycle after one previous IUI failure . It was concluded that ESI in the mid‐proliferative phase was associated with increase of pregnancy rate after one IUI failure . Elsewhere, Wadhwa et al evaluated the impact of endometrial biopsy (EB) on IUI outcome, and concluded that EB conducted in the early follicular phase in the same cycle of stimulation is associated with better clinical pregnancy rate in comparison with EB performed in the luteal phase of the previous menstrual cycle .…”

“…The results were controversial: different timings of scratch, that is, in the late luteal phase of the previous cycle or in the early follicular phase, have led to varied outcome . A limited number of well‐designed studies have been performed to assess the impact of ESI on IUI outcome . Lensen et al , in a recent review of nine randomized clinical trials, suggested a beneficial effect of ESI on the chance of pregnancy; but they noted that the studies were associated with many important limitations .…”