Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination

Bui, Bich Ngoc; Lensen, Sarah; Gibreel, Ahmed; Martins, W.P.; Torrance, Helen; Broekmans, Frank J.

doi:10.1002/14651858.cd011424.pub3

Cited by 7 publications

(3 citation statements)

References 89 publications

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“…The results of this study are consistent with the data of a recent meta-analysis of 23 randomized controlled trials, including 4,035 women (mostly with unexplained infertility), on the effectiveness and safety of intentional endometrial injury performed in infertile women attempting to conceive without assistance or through IUI (5). Moreover, the metaanalysis failed to show a beneficial effect on the live birth or ongoing pregnancy rates between the endometrial injury group and no-intervention or sham procedure group.…”

supporting

confidence: 88%

Endometrial scratch to improve outcomes of expectant management in patients with unexplained infertility?

Hosseinzadeh

Hansen

2022

Fertility and Sterility

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supporting

confidence: 88%

Endometrial scratch to improve outcomes of expectant management in patients with unexplained infertility?

Hosseinzadeh

Hansen

2022

Fertility and Sterility

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“…In patients scheduled for free sexual intercourses, the ES, performed during the early follicular phase, induced a pain about 3 points higher in pain score [ 6 , 7 ]. However, the ES performed during the early follicular phase was associated with fewer pain scores than during the luteal phase [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…This is true for infertile patients scheduled for a first in vitro fertilization (IVF) cycle [ 3 ] and for unselected infertile patients who received an IVF treatment [ 4 ]. No clear efficacy of the ES has been demonstrated in infertile couples with unexplained or anovulatory infertility, who received intrauterine insemination (IUI) and ovulation inductors followed by free or timed sexual intercourses [ 5 ]. Two recent randomized controlled trials (RCTs) showed that ES does not improve the reproductive outcomes in infertile patients with polycystic ovary syndrome (PCOS) who receive fertility drugs [ 6 ] or with unexplained infertility [ 7 ] who had regular intercourses.…”

Section: Introductionmentioning

confidence: 99%

Fertility specialists’ views, behavior, and attitudes towards the use of endometrial scratching in Italy

Palomba,

Carone,

Vitagliano

et al. 2023

BMC Women's Health

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Background Endometrial scratching (ES) or injury is intentional damage to the endometrium performed to improve reproductive outcomes for infertile women desiring pregnancy. Moreover, recent systematic reviews with meta-analyses and randomized controlled trials demonstrated that ES is not effective, data on the safety are limited, and it should not be recommended in clinical practice. The aim of the current study was to assess the view and behavior towards ES among fertility specialists throughout infertility centers in Italy, and the relationship between these views and the attitudes towards the use of ES as an add-on in their commercial setting. Methods Online survey among infertility centers, affiliated to Italian Society of Human Reproduction (SIRU), was performed using a detailed questionnaire including 45 questions with the possibility to give “closed” multi-choice answers for 41 items and “open” answers for 4 items. Online data from the websites of the infertility centers resulting in affiliation with the specialists were also recorded and analyzed. The quality of information about ES given on infertility centers websites was assessed using a scoring matrix including 10 specific questions (scored from 0 to 2 points), and the possible scores ranged from 0 to 13 points (‘excellent’ if the score was 9 points or more, ‘moderate’ if the score was between 5 and 8, and ‘poor’ if it was 4 points or less). Results The response rate was of 60.6% (43 questionnaires / 71 infertility SIRU-affiliated centers). All included questionnaires were completed in their entirety. Most physicians (~ 70%) reported to offer ES to less than 10% of their patients. The procedure is mainly performed in the secretory phase (69.2%) using pipelle (61.5%), and usually in medical ambulatory (56.4%) before IVF cycles to improve implantation (71.8%) without drugs administration (e.g., pain drugs, antibiotics, anti-hemorrhagics, or others) before (76.8%) or after (64.1%) the procedure. Only a little proportion of infertility centers included in the analysis proposes formally the ES as an add-on procedure (9.3%), even if, when proposed, the full description of the indications, efficacy, safety, and costs is never addressed. However, the overall information quality of the websites was generally “poor” ranging from 3 to 8 and having a low total score (4.7 ± 1.6; mean ± standard deviation). Conclusions In Italy, ES is a procedure still performed among fertility specialists for improving the implantation rate in IVF patients. Moreover, they have a poor attitude in proposing ES as an add-on in the commercial setting.

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Endometrial injury in women undergoing in vitro fertilisation (IVF)

Lensen

Armstrong

Gibreel

et al. 2021

Cochrane Database of Systematic Reviews

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Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination

Cited by 7 publications

References 89 publications

Endometrial scratch to improve outcomes of expectant management in patients with unexplained infertility?

Endometrial scratch to improve outcomes of expectant management in patients with unexplained infertility?

Fertility specialists’ views, behavior, and attitudes towards the use of endometrial scratching in Italy

Endometrial injury in women undergoing in vitro fertilisation (IVF)

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