Local Changes in Microcirculation and the Analgesic Effects of Acupuncture: A Laser Doppler Perfusion Imaging Study

Min, Seorim; Lee, Hyangsook; Kim, Song-Yi; Park, Ji-Yeun; Chae, Younbyoung; Lee, Hyejung; Park, Hi-Joon

doi:10.1089/acm.2013.0442

Cited by 41 publications

(47 citation statements)

References 22 publications

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“…e manipulation of acupuncture is a key component in the treatment process, and different manipulations may result in significantly different outcomes [24]. Acupoint ST36 of the stomach meridian of Foot-Yangming is an important acupoint for the regulation of gastric motility, as shown in several studies [25,26]. e present study confirmed that different manipulations on ST36 had varying effects on gastric electrical amplitude and frequency.…”

Section: Discussionsupporting

confidence: 78%

Effects of Varying Acupuncture Manipulations at ST36 (Zusanli) on Gastric Electrical Frequency and Amplitude in Bradygastria Rabbits

Wang

Niu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To observe the effects of different manual acupuncture (MA) manipulation on gastric electrical amplitude and frequency for noradrenaline-induced bradygastria in rabbits. Methods. A total of 60 rabbits were randomly allocated into six groups: four MA manipulation groups; reinforcing by twisting the manipulation group (FTG), reducing by twisting the manipulation group (RTG), reinforcing by lifting and thrusting the manipulation group (FLG), and reducing by lifting and thrusting the manipulation group (RLG), a control group (CG), and a model group (MG). e total treatment time length was 45 minutes. e bradygastria was induced via administration of noradrenaline via the marginal ear vein of the rabbits at 5 minutes from baseline, and the bradygastria model was established at 12 minutes from baseline. e rabbits in the four MA manipulation groups received different stimulation parameters at ST36 (Zusanli) for a duration of 3 minutes in accordance with their respective group allocation. e needles were then retained without further manipulation for a further 25 minutes. Gastric electrical amplitude and frequency were recorded using a data acquisition system (Biopac System MP150) at five different time points: baseline (for a duration of 5 minutes), after the bradygastria model was established at 12 minutes from baseline (for a duration of 5 minutes), during MA manipulation commencing at 17 minutes from baseline (for a duration of 3 minutes), 5 minutes after MA manipulation at 25 minutes from baseline (for a duration of 5 minutes), and at 20 minutes following MA manipulation at 40 minutes from baseline (for a duration of 5 minutes). Results. After noradrenaline induction, gastric electrical frequency levels in MA and MG groups were significantly decreased compared to the CG group (P < 0.05). However, there were no significant changes to gastric electrical amplitude (P > 0.05). During MA manipulation, gastric electrical frequency levels in RTG, FLG, and RLG groups were higher than in the MG group (P < 0.05). At 5 minutes after MA manipulation, gastric electrical frequency levels in RTG and FLG groups were higher than in the MG group (P < 0.05), and gastric electrical frequency level in the RTG group was higher than in the CG group (P < 0.05). At 20 minutes after MA manipulation, gastric electrical frequency levels in FTG, RTG, and FLG groups were higher than in the MG group (P < 0.05). Conclusion. All four variations of MA manipulations have a recovery effect on the gastric electrical frequency of rabbits with bradygastria. In particular, results indicated that FTG, RTG, and FLG at ST36 may have a regular and significant recovery trend through the whole process of the acupuncture intervention.Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 9357120, 9 pages https://doi.

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Section: Discussionsupporting

confidence: 78%

Effects of Varying Acupuncture Manipulations at ST36 (Zusanli) on Gastric Electrical Frequency and Amplitude in Bradygastria Rabbits

Wang

Niu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…For myofascial disorder, what will happen when it is needled directly? Acupuncture was shown to trigger a local increase in adenosine in human subjects [49,50] and to increase local microcirculation [40,41]. It is still controversial whether a trigger point is a central or peripheral phenomenon [11].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, both SP and CGRP were significantly lower in the acupotomy group than the model group, which is consistent with the common observation of decreased pain after TrP treatment. Acupuncture increases local nitric oxide and microcirculation [40,41], so local microcirculation in TrPs should be evaluated before and after needling to determine whether it dilutes algogenic substances.…”

Section: Cgrp Enhances Ach Effect At Motor Endplatementioning

confidence: 99%

Acupotomy Alleviates Energy Crisis at Rat Myofascial Trigger Points

Zhang

Du²,

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to determine the effects of acupotomy on energy crises in rat trigger points (TrPs) by measuring mechanical pain thresholds (MPTs) and levels of acetylcholinesterase (AChE), free sarcoplasmic calcium (Ca2+), adenosine 5′-triphosphate (ATP), adenosine 5′-monophosphate (AMP), substance P (SP), and calcitonin gene-related peptide (CGRP) in rat muscle TrP tissue. Male Sprague Dawley rats (n = 32) were randomly divided into four groups: control, TrP, acupotomy, and lidocaine injection. Enzyme-linked immunosorbent assays were used to measure AChE, and free sarcoplasmic Ca2+ concentrations were determined by fluorescent staining with Fura-2 AM; high-performance liquid chromatography was used to measure ATP and AMP, and SP and CGRP were evaluated by immunohistochemistry. Compared with the control group, free sarcoplasmic Ca2+, AMP, SP, and CGRP were higher in the model group, while MPT, AChE, and ATP were lower. Treatment with acupotomy or lidocaine injection reduced free sarcoplasmic Ca2+, SP, and CGRP and increased MPTs and AChE levels compared with the model group. However, only acupotomy also led to decreased AMP and increased ATP levels relative to the model group. We conclude that acupotomy can alleviate energy crises at TrPs.

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“…In addition, improved microcirculation coupled with analgesic effects of needle stimulation could bring about long term improvements. Given the self-reported improvement the patient has experienced, acupuncture may be an option for those suffering from arthritis who wish to reduce their reliance on medication [8][9]. One particular issue of note is that the patient is on Plavix, an anticoagulant prescribed to those who are unable to take aspirin as the standard blood thinner (either due to allergy or contradicting drug interactions), which is listed with the side effect of joint pain, and in some instances, the uncommon side effect of acute osteoarthritis.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Application of Acupuncture to Treat Knee Pain

Xu¹

2018

JONAM

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This case study presents an 86 year old female patient suffering severe pain resulting from knee osteoarthritis, seeking acupuncture as a treatment option to alleviate her symptoms. After four treatments, patient self-reported significant improvement in range of motion and decrease in pain, which allowed for higher quality of life. It should be noted that the patient is taking Plavix, an anticoagulant for those intolerant of aspirin, which has the reported side effect of joint pain. It is also possible that acupuncture is acting to decrease the medication side effects. Based on these results, acupuncture may be a viable option as a complementary mode of treatment for symptom management that warrants further investigation.

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Local Changes in Microcirculation and the Analgesic Effects of Acupuncture: A Laser Doppler Perfusion Imaging Study

Abstract: These results suggested that repeated manipulation induced higher local microcirculatory changes that were correlated with the analgesic effects at the relevant sites. The findings suggest that a proper dose of acupuncture stimulation might be essential to elicit the acupuncture effects.

Cited by 41 publications

References 22 publications

Effects of Varying Acupuncture Manipulations at ST36 (Zusanli) on Gastric Electrical Frequency and Amplitude in Bradygastria Rabbits

Effects of Varying Acupuncture Manipulations at ST36 (Zusanli) on Gastric Electrical Frequency and Amplitude in Bradygastria Rabbits

Acupotomy Alleviates Energy Crisis at Rat Myofascial Trigger Points

Case Report: Application of Acupuncture to Treat Knee Pain

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