Effects of Varying Acupuncture Manipulations at ST36 (Zusanli) on Gastric Electrical Frequency and Amplitude in Bradygastria Rabbits

Wang, Kang; Xu, Yueyue; Niu, Yan; Liu, Yangyang; Lai, Hezheng; Xu, Zhifang; Zhang, Kuo; Guo, Yongming; Guo, Yi

doi:10.1155/2020/9357120

“…Acupuncture has a benign adjustment effect on gastrointestinal function. Acupuncture at Zusanli (ST36) acupoint could significantly recover the gastric electrical amplitude and frequency in noradrenaline-induced bradygastria rabbits (Wang et al, 2020b;Wang, Liu, Hu, Zhang, & Shen, 2020). The enhancement of gastric motility by acupuncture can inhibit the glutamatergic system in the hippocampus , Wang, Xu, et al, 2020b.…”

Section: Gastrointestinal Disordersmentioning

confidence: 99%

“…Acupuncture at Zusanli (ST36) acupoint could significantly recover the gastric electrical amplitude and frequency in noradrenaline-induced bradygastria rabbits (Wang et al, 2020b;Wang, Liu, Hu, Zhang, & Shen, 2020). The enhancement of gastric motility by acupuncture can inhibit the glutamatergic system in the hippocampus , Wang, Xu, et al, 2020b. Acupuncture at ST36 could also restore the enteric motor neuron function by regulating the expression of nitric oxide synthase and choline acetyltransferase (Yu, 2020).…”

Section: Gastrointestinal Disordersmentioning

confidence: 99%

Acupuncture, from the ancient to the current

Zhu

¹

,

Li

²

,

Liu

³

2021

The Anatomical Record

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Acupuncture is characterized by the insertion of a fine metal needle through the skin of the human body at an acupuncture point (acupoint) in Traditional Chinese Medicine (TCM). It is an ancient form of therapy, and has a long history of prosperity and decline. Due to the persistent efforts of TCM practitioners, a number of well-designed clinical trials regarding acupuncture have been published in the past decade. Besides, numerous basic researches aiming to reveal the mechanisms of acupuncture have also been conducted. Several scientific explanations have been obtained to interpret the arcane TCM theory.This review provides brief information of acupuncture, including its history, status, evidence, and mechanisms.

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“…Fang et al showed that the differential effects of electroacupuncture (EA) on NTS neuron excitability in normal rats may be caused by different combinations of acupoint and frequency selection [ 22 ]. Furthermore, different effects on gastric electrical frequency and amplitude in bradygastria rabbits were related to different manual acupuncture (MA) manipulations of acupoint ST36 [ 23 ]. In their in vivo studies, Yang et al showed that not only needle retention, but also treatment frequency and needle manipulation, were significant determinants of hippocampal learning, memory, and neuron damage in VD rats [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Acupuncture Parameters on Efficacy and the Possible Use of Acupuncture in Combination with or as a Substitute for Drug Therapy in Patients with Ulcerative Colitis

Chen

¹

,

Zhao

²

,

Guo

³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Ulcerative colitis (UC) is an inflammatory disease of the colonic mucosa, which is accompanied by chronic, idiopathic characteristics. Acupuncture may be an effective therapy for UC. Here we focused on manual acupuncture and electroacupuncture (MA/EA), two widely used and studied acupuncture interventions, to probe the effects of acupuncture parameters on clinical efficacy in patients with UC and the use of MA/EA alone or with other drugs to support their wider adoption in clinical practice. Methods. The PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure Database, and Wanfang databases were searched from inception to April 27, 2021. Randomized clinical trials (RCTs) published in Chinese or English were included, and subgroup analyses were performed according to acupuncture parameter, acupuncture type, and control medicine type. The risk of bias was assessed using the Cochrane Risk of Bias tool and modified Jadad scale, and Review Manager 5.4 and Stata 14.0 were used to perform a meta-analysis. Sources of heterogeneity were explored; sensitivity analysis was performed; and the GRADE methodology was used to assess the evidence level. Results. Sixteen studies (1454 individuals) were included. Retention of the needle [10–30 minutes (RR 1.18, 95% CI [1.11, 1.26], P < 0.01 ; heterogeneity: χ2 = 6.25, df = 6 ( P = 0.40 ), I2 = 4%)], the frequency of MA [once every other day (RR 1.21, 95% CI [1.08, 1.35], P < 0.01 ; heterogeneity: χ2 = 0.80, df = 1 ( P = 0.37 ), I2 = 0%)], and the length of treatment [8 weeks (RR 1.35, 95% CI [1.01, 1.81], P = 0.04 )] improved clinical efficacy at the end of treatment compared with medications alone. MA (RR 1.18, 95% CI [1.11, 1.25], P < 0.01 ; heterogeneity: χ2 = 6.19, df = 7 ( P = 0.52 ), I2 = 0%) increased clinical efficacy compared with medications. Furthermore, MA plus medications (RR 1.26, 95% CI [1.13, 1.40], P < 0.01 ; heterogeneity: χ2 = 0.95, df = 2 ( P = 0.62 ), I2 = 0%) and EA plus medications (RR 1.36, 95% CI [1.13, 1.63], P < 0.01 ; heterogeneity: χ2 = 0.13, df = 1 ( P = 0.72 ), I2 = 0%) both dramatically improved clinical efficacy. The clinical efficacy of MA plus mesalazine or MA plus metronidazole and sulfasalazine was greater than with mesalazine or metronidazole and sulfasalazine alone. Similarly, EA plus sulfasalazine was more effective than sulfasalazine alone. MA/EA resulted in fewer adverse reactions than medical therapies. The use of MA plus medications significantly reduced Baron scores. GRADE evaluations indicated that the evidence strength was moderate to low but mostly low. Conclusions. Our study provides the latest evidence to allow us to speculate about the possible optimal MA parameters to treat patients with UC. The low number of adverse reactions and high efficacy make MA/EA a possible supplement to or replacement for traditional UC drugs. The variable parameter settings preferred by patients and acupuncturists may be an important factor limiting the wider clinical deployment of acupuncture as a potential UC therapy.

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“…We demonstrated that acupuncture at “ST36 + GV20” was more effective than “ST36 + SP10” or “GV20 + SP10” in VD rats (Ye et al., 2017). Most research has focused on acupoint specificity, less on exploring the effect of acupuncture manipulation (K. Wang et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Standardizing therapeutic parameters of acupuncture in vascular dementia rats

Yang

¹

,

Ma

²

,

Yang

³

et al. 2020

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Vascular dementia (VD) is a heterogeneous group of brain disorders associated with loss of memory and cognitive function resulting from vascular lesions. It is the second leading cause of cognitive impairment after Alzheimer's disease (AD) in the elderly (Du et al., 2013). In developing countries, VD accounts for approximately 30% of the age-adjusted dementia prevalence and in Western countries (Kalaria et al., 2008), the rate of VD is approximately1%-4% in people at the age of 65 (McVeigh & Passmore, 2006). The WHO estimates that 50 million people have dementia, a number that is anticipated to triple by 2050. As people live longer, the burden of

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Effects of Varying Acupuncture Manipulations at ST36 (Zusanli) on Gastric Electrical Frequency and Amplitude in Bradygastria Rabbits

Cited by 3 publications

References 27 publications

Acupuncture, from the ancient to the current

Acupuncture, from the ancient to the current

The Influence of Acupuncture Parameters on Efficacy and the Possible Use of Acupuncture in Combination with or as a Substitute for Drug Therapy in Patients with Ulcerative Colitis

Standardizing therapeutic parameters of acupuncture in vascular dementia rats

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