Local cerebral glucose utilization during waking and slow wave sleep in the cat. A [14C]deoxyglucose study

Petitjean, F; Seguin, S.; Rosiers, M.H. Des; Salvert, Denise; Buda, C; Janin, M; Debilly, G.; Jouvet, Michel; Bobillier, Pierre

doi:10.1016/0304-3940(82)90235-x

Cited by 13 publications

(1 citation statement)

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“…The overall level of brain metabolism appears to be maintained during sleep as determined by measurement of arteriovenous differences in oxygen content (Mangold et al, 1955;Reivich et al, 1968). Recent studies by the ['4C]2-deoxyglucose method indicate that local cerebral glucose utilization in the rat is unchanged in SWS, compared with wakefulness (Petitjean et al, 1982). However, a circadian rhythm does pertain with respect to cerebral glucose utilization in the conscious rat (Crane et al, 1980).…”

Section: Discussionmentioning

confidence: 99%

Changes in Brain Glycogen During Slow‐Wave Sleep in the Rat

Karnovsky

Reich

Anchors

et al. 1983

Journal of Neurochemistry

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Section: Discussionmentioning

confidence: 99%

Changes in Brain Glycogen During Slow‐Wave Sleep in the Rat

Karnovsky

Reich

Anchors

et al. 1983

Journal of Neurochemistry

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Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat: A preliminary study

Lydic

Baghdoyan

Hibbard

et al. 1991

J of Comparative Neurology

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Glucose utilization was measured in 74 brain regions of the cat during states of wakefulness or rapid eye movement (REM) sleep. These data were obtained from intact, unanesthetized animals which were instrumented for objectively measuring states of consciousness. Through a chronically implanted intravenous catheter, the cats received 250 microCi of magnitude of 6-14C glucose during REM sleep (N = 3) or during wakefulness (N = 3). After spending approximately 8 min in REM sleep or in quiet wakefulness, the cats were administered a lethal dose of barbiturate and the brains were removed and processed for autoradiography. The results revealed site-specific changes in glucose metabolism during REM sleep. Significant alterations in glucose use occurred in the thalamus, the limbic system, and specific regions of the pontine reticular formation. These data demonstrate for the first time that during states comprised entirely of REM sleep there are anatomically specific changes in cerebral glucose metabolism. The majority of brain regions exhibiting REM sleep-dependent changes in glucose metabolism either overlapped with regions known to contain cholinergic cell bodies, or with areas that receive prominent cholinergic input.

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Functional Correlates of Acute Prolonged Pain in the Rat Central Nervous System: 2-DG Studies

Porro

Cavazzuti

1992

Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions

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Local cerebral glucose utilization during waking and slow wave sleep in the cat. A [14C]deoxyglucose study

Cited by 13 publications

References 10 publications

Changes in Brain Glycogen During Slow‐Wave Sleep in the Rat

Changes in Brain Glycogen During Slow‐Wave Sleep in the Rat

Regional brain glucose metabolism is altered during rapid eye movement sleep in the cat: A preliminary study

Functional Correlates of Acute Prolonged Pain in the Rat Central Nervous System: 2-DG Studies

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