Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants

Jiang, Wei; Hou, Fushan; Gu, Yun; Saiding, Qimanguli; Bao, Ping‐Ping; Tang, Jincheng; Wu, Liang; Chen, Chunmao; Shen, Cailiang; Pereira, Catarina Leite; Sarmento, Marco; Sarmento, Bruno; Cui, Wenguo; Chen, Liang

doi:10.1016/j.bioactmat.2021.10.017

Cited by 10 publications

(11 citation statements)

References 44 publications

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“…It not only leads to an increased risk of fragility fracture but also negatively affects surgical outcomes following orthopaedic surgery. Reduced bone mineral density (BMD) may compromise implant fixation strength, eventually leading to implant loosening and surgical failure 2,3 . In the study by Chung et al, for example, patients with osteoporosis had a sevenfold increased risk of retear following arthroscopic rotator cuff repair 4 .…”

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confidence: 99%

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Lactate Mediates the Bone Anabolic Effect of High-Intensity Interval Training by Inducing Osteoblast Differentiation

Zhu

Chen

Zou

et al. 2023

Journal of Bone and Joint Surgery

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Background:High-intensity interval training (HIIT) reportedly improves bone metabolism and increases bone mineral density (BMD). The purpose of the present study was to investigate whether lactate mediates the beneficial effects of exercise on BMD, bone microarchitecture, and biomechanical properties in an established osteoporotic animal model. In addition, we hypothesized that lactate-induced bone augmentation is achieved through enhanced osteoblast differentiation and mineralization.Methods:A total of 50 female C57BL/6 mice were randomly allocated into 5 groups: the nonovariectomized group, the ovariectomized group (OVX), the HIIT group (OVX + HIIT), the HIIT with lactate transporter inhibition group (OVX + HIIT + INH), and the lactate subcutaneous injection group (OVX + LAC). After 7 weeks of intervention, bone mass, bone strength, and bone formation/resorption processes were evaluated via microcomputed tomography (micro-CT), biomechanical testing, histological analysis, and serum biochemical assays; in vitro studies were performed to explore the bone anabolic effect of lactate at the cellular level.Results:Micro-CT revealed significantly increased BMD in both the OVX + HIIT group (mean difference, 41.03 mg hydroxyapatite [HA]/cm3 [95% CI, 2.51 to 79.54 mg HA/cm3]; p = 0.029) and the OVX + LAC group (mean difference, 40.40 mg HA/cm3 [95% CI, 4.08 to 76.71 mg HA/cm3]; p = 0.031) compared with the OVX group. Biomechanical testing demonstrated significantly improved mechanical properties in those 2 groups. However, the beneficial effects of exercise on bone microstructure and biomechanics were largely abolished by blocking the lactate transporter. Notably, histological and biochemical results indicated that increased bone formation was responsible for the bone augmentation effects of HIIT and lactate. Cell culture studies showed a marked increase in the expression of osteoblastic markers with lactate treatment, which could be eliminated by blocking the lactate transporter.Conclusions:Lactate may have mediated the bone anabolic effect of HIIT in osteoporotic mice, which may have resulted from enhanced osteoblast differentiation and mineralization.Clinical Relevance:Lactate may mediate the bone anabolic effect of HIIT and serve as a potential inexpensive therapeutic strategy for bone augmentation.

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Lactate Mediates the Bone Anabolic Effect of High-Intensity Interval Training by Inducing Osteoblast Differentiation

Zhu

Chen

Zou

et al. 2023

Journal of Bone and Joint Surgery

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“…1 d–e). We hypothesized that this Ca 2+ /Mg 2+ -releasing characterization of our CMS hydrogel was suitable for its application as a bone regenerative scaffold [ [23] , [24] , [25] , [26] ]. We speculated that after the CMS hydrogel filled the bone defects, the early burst release of Ca 2+ /Mg 2+ would help to create a suitable microenvironment for rapid bone regeneration; next, the subsequent constant release of Ca 2+ /Mg 2+ would trigger the osteogenesis of the pre-loaded and infiltrated BMSCs; and finally, the slow release of Ca 2+ /Mg 2+ would provide a long-term conductive microenvironment to the bone regeneration.…”

Section: Resultsmentioning

confidence: 99%

An injectable and self-healing hydrogel with dual physical crosslinking for in-situ bone formation

et al. 2023

Materials Today Bio

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“…The chemical cross-linking mechanisms such as Schiff's Base, free radical polymerization, N-ethyl-N'- (3-(dimethylamino)propyl)carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling, and enzymecatalyzed crosslinking reactions are the common chemical reactions for building a tough adhesive. [58][59][60] Depending on the reversibility of chemical bonds, those adhesive hydrogels can be classified as chemical 42 wound healing, 43 and scaffolds for orthopedic implants 44 ). Reproduced with permission from Ref.…”

Section: Key Pointsmentioning

confidence: 99%

Functional adhesive hydrogels for biological interfaces

Liu,

Peng,

et al. 2023

Smart Medicine

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Hydrogel adhesives are extensively employed in biological interfaces such as epidermal flexible electronics, tissue engineering, and implanted device. The development of functional hydrogel adhesives is a critical, yet challenging task since combining two or more attributes that seem incompatible into one adhesive hydrogel without sacrificing the hydrogel's pristine capabilities. In this Review, we highlight current developments in the fabrication of functional adhesive hydrogels, which are suitable for a variety of application scenarios, particularly those that occur underwater or on tissue/organ surface conditions. The design strategies for a multifunctional adhesive hydrogel with desirable properties including underwater adhesion, self‐healing, good biocompatibility, electrical conductivity, and anti‐swelling are discussed comprehensively. We then discuss the challenges faced by adhesive hydrogels, as well as their potential applications in biological interfaces. Adhesive hydrogels are the star building blocks of bio‐interface materials for individualized healthcare and other bioengineering areas.

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Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants

Cited by 10 publications

References 44 publications

Lactate Mediates the Bone Anabolic Effect of High-Intensity Interval Training by Inducing Osteoblast Differentiation

Lactate Mediates the Bone Anabolic Effect of High-Intensity Interval Training by Inducing Osteoblast Differentiation

An injectable and self-healing hydrogel with dual physical crosslinking for in-situ bone formation

Functional adhesive hydrogels for biological interfaces

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