Local Blood Flow and Oxygen Metabolism in Glioma and Its Surrounding Brain

Taki, Waro; Handa, Hajime; Ishikawa, M.; Kobayashi, Akira; Yamashita, Jyunko; Yonekawa, Y; Tanada, Shuji; Senda, Michio; Yonekura, Y; Torizuka, K; Fujita, Toshiaki; Fukuyama, Hidenao; Harada, Kiyoshi; Fujimoto, Naoki; Kameyama, Michitaka

doi:10.1007/978-3-642-70696-7_41

Cited by 3 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The regional oxygen extraction ratio in peritumor tissue was not increased, indicating a reduced metabolic rate (Ito et al, 1982;Taki et al, 1985;Tsubokawa et al, 1985). In a rat glioma brain tumor model, regional cerebral glucose utilization (rCGU) was bilaterally depressed in the telencephalic structures (Hossmann et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

“…Positron emission tomography (PET) studies of patients with brain tumors have demonstrated decreased regional cerebral blood flow and both oxygen and glucose metabolism in peritumor tissue (Di Chiro et al, 1982;Tsubokawa et al, 1985), as well as in more remote regions (Ito et al, 1982;Taki et al, 1985). The regional oxygen extraction ratio in peritumor tissue was not increased, indicating a reduced metabolic rate (Ito et al, 1982;Taki et al, 1985;Tsubokawa et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Regional monoamine and metabolite levels in a feline brain tumor model

Bayens-Simmonds

Boisvert

Baker

1989

Molecular and Chemical Neuropathology

View full text Add to dashboard Cite

The presence of a brain tumor alters regional cerebral blood flow, oxygen consumption, and glucose utilization in adjacent and remote brain tissue, but its effect on brain neurotransmitter levels is unclear. In the present report, the levels of noradrenaline (NA), dopamine (DA), 5-hydroxytryptamine (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in tumor tissue and gray and white matter obtained from cats with induced brain tumors were measured. Glioma cells (9L) were xenotransplanted into the central white matter of the right hemisphere, and 15 d later the brains were frozen in vivo. Samples of tumor, parietal (peritumor), temporal, and frontal gray and white matter were divided for analysis of water content and quantification of amines and their metabolites. The water content of white matter, but not gray matter, adjacent to the tumor was increased. Neurotransmitter amine and metabolite levels were much lower in the tumor than in brain tissue. In gray matter adjacent to the tumor, concentrations of DA and its metabolites HVA and DOPAC were significantly decreased from control, whereas 5-HIAA was increased. The NA, DA, HVA, and DOPAC levels were decreased in temporal gray matter, whereas all amine and metabolite levels were unchanged in frontal gray matter. These results indicate that altered neurotransmitter metabolism is one of the effects of the presence of a brain tumor.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Regional monoamine and metabolite levels in a feline brain tumor model

Bayens-Simmonds

Boisvert

Baker

1989

Molecular and Chemical Neuropathology

View full text Add to dashboard Cite

show abstract

Effect of dexamethasone on monoamine and metabolite levels in a brain-tumor model

Bayens-Simmonds

Boisvert

Baker

1989

Brain Research Bulletin

View full text Add to dashboard Cite

Cerebral bloodflow in and around spontaneous malignant gliomas

Toglia

Kittelson

Roemer

et al. 1996

International Journal of Hyperthermia

View full text Add to dashboard Cite

Knowledge of the cerebral bloodflow (CBF) in and around malignant gliomas is of crucial importance in developing strategies for hyperthermia-, radiation-, and chemo-therapy of these difficult to cure lesions. To gather data regarding this important physiological variable, the perfusion distributions of 26 patients who had either a glioblastoma multiforme or an anaplastic astrocytoma were determined using stable xenon computed tomography (XeCT). Perfusion values were determined for each of the following anatomical regions: low density tumour core, the enhancing active ring of the tumour, the low density peripheral region of edema, an ipsilateral region of normal brain adjacent to the tumour, and a region of remote normal tissue on the contralateral side of the brain. A multiple regression analysis of the logs of the CBF values was used to analyse: (1) the differences in blood perfusion between the anatomical regions; and (2) the association of blood perfusion with various patient and tumour characteristics. Statistically significant differences in perfusion values were found between all of the anatomically outlined regions with the exceptions that the active tumour and edematous regions do not differ significantly from the ipsilateral normal brain tissue. The ipsilateral normal brain tissue adjacent to the tumour was found to have a relative perfusion (relative to the contra-lateral normal brain tissue perfusion) of 0.84, the edematous tissue had a relative perfusion of 0.52, the active tumour 0.78, and the core 0.39. Significant blood flow was present in the low density tumour core, contradicting the frequent assumption that there is zero or minimal blood flow in such regions. Multiple regression analysis was used to look for other variables that might be associated with blood flow after adjusting for the differences between anatomical regions. This analysis found a significant negative correlation between tumour blood-flow and tumour volume. It also estimated that blood flow in GMB tumours was approximately 67% of that in lower grade tumours. Variables that were found not to be significantly correlated with blood flow were: patient sex, multiple lobe involvement, hemisphere involved, treatment status (initial vs recurrent disease), Karnofsky performance status, age and, lobe involved.

show abstract

Local Blood Flow and Oxygen Metabolism in Glioma and Its Surrounding Brain

Cited by 3 publications

References 2 publications

Regional monoamine and metabolite levels in a feline brain tumor model

Regional monoamine and metabolite levels in a feline brain tumor model

Effect of dexamethasone on monoamine and metabolite levels in a brain-tumor model

Cerebral bloodflow in and around spontaneous malignant gliomas

Contact Info

Product

Resources

About