Effect of dexamethasone on monoamine and metabolite levels in a brain-tumor model

Endocrine aspects of the diagnosis and treatment of primary brain tumours

“…The reduction of peritumoral oedema around brain tumours by glucocorticoids is probably mediated via the capillary endothelial cells rather than directly via the tumour cells (Ohnishi et al, 1990). Direct anti-mitotic effects on glial tumour cells have also been shown, however, and seem in most instances to be mediated via specific glucocorticoid receptors (Mackie et al, 1988;Elleman et al, 1988;Bayens-Simmonds et al, 1989;Lordo et al, 1989;Paoletti et al, 1990).…”