Local Anesthetic–Induced Inhibition of Human Neutrophil Priming

Picardi, Susanne; S, Cartellieri; Groves, Danja S.; Hahnenekamp, Klaus; Gerner, Peter; Durieux, Marcel E.; Stevens, Markus F.; Lirk, Philipp; Hollmann, Markus W.

doi:10.1097/aap.0b013e31827a3cbe

Cited by 30 publications

(6 citation statements)

References 14 publications

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“…Based on GEF-induced attenuations of MeHg neurotoxicity without involvement of LPA receptor regulations, it will be interesting to consider what are the molecular mechanisms of GEF-mediated attenuation on in vitro MeHg-induced neurotoxicity and in vivo MeHg-induced memory impairments. MeHg has positive charges and GEF contains negative charged components such as phosphatidic acids [32][33][34]. Thus, the first possibility is that the negative charged components of GEF might bind positive MeHg and interrupt MeHg-induced neurotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination

Kim

Choi

Lee

et al. 2020

IJERPH

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Gintonin is a newly discovered ingredient of ginseng and plays an exogenous ligand for G protein-coupled lysophosphatidic acid receptors. We previously showed that gintonin exhibits diverse effects from neurotransmitter release to improvement of Alzheimer’s disease-related cognitive dysfunctions. However, previous studies did not show whether gintonin has protective effects against environmental heavy metal. We investigated the effects of gintonin-enriched fraction (GEF) on methylmercury (MeHg)-induced neurotoxicity and learning and memory dysfunction and on organ MeHg elimination. Using hippocampal neural progenitor cells (hNPCs) and mice we examined the effects of GEF on MeHg-induced hippocampal NPC neurotoxicity, on formation of reactive oxygen species (ROS), and on in vivo learning and memory functions after acute MeHg exposure. Treatment of GEF to hNPCs attenuated MeHg-induced neurotoxicity with concentration- and time-dependent manner. GEF treatment inhibited MeHg- and ROS inducer-induced ROS formations. Long-term treatment of GEF also improved MeHg-induced learning and memory dysfunctions. Oral administration of GEF decreased the concentrations of MeHg in blood, brain, liver, and kidney. This is the first report that GEF attenuated MeHg-induced in vitro and in vivo neurotoxicities through LPA (lysophosphatidic acids) receptor-independent manner and increased organ MeHg elimination. GEF-mediated neuroprotection might achieve via inhibition of ROS formation and facilitation of MeHg elimination from body.

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Section: Discussionmentioning

confidence: 99%

Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination

Kim

Choi

Lee

et al. 2020

IJERPH

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“…Nowadays, more and more data on the so-called “alternative effects” of LAs is being published. With the increase in data, a better understanding of the broad spectrum of therapeutic uses of LAs comes, for example, its anti-inflammatory [ 20 ] and immunomodulating properties [ 21 ], applications in oncology [ 22 , 23 ], and uses in treating chronic CRPS [ 24 ] as well as chronic pain and functional disorders [ 25 ]. The therapeutic use of LAs, also known as neural therapy (NT) or therapeutic local anesthesia (TLA), is more relevant than ever [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…The therapeutic use of LAs, also known as neural therapy (NT) or therapeutic local anesthesia (TLA), is more relevant than ever [ 2 ]. Short-acting ELAs and ALAs seem to be more potent in anti-inflammation and immune regulation, than long-acting LAs [ 21 ]. According to our results ELAs are at least equally suited for therapeutic use.…”

Section: Discussionmentioning

confidence: 99%

Local Anesthetics, Procaine, Lidocaine, and Mepivacaine Show Vasodilatation but No Type 1 Allergy: A Double-Blind, Placebo-Controlled Study

Weinschenk

Mergenthaler

Armstrong

et al. 2017

BioMed Research International

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Background Therapy with local anesthetics (LAs), also known as neural therapy, is used in integrative medicine because of its anti-inflammatory properties. Ester-linked LAs are often avoided because of their alleged high allergenicity. Little data supports this assumption and hence the importance of our investigation on type-1 allergies against ester- and amide-linked LAs. We performed a prospective, double-blinded, placebo-controlled observational study. Methods 177 patients received 340 intracutaneous injections with 1% procaine, 0.5% lidocaine, 1% mepivacaine, or saline solution. Every patient received two different tests on each forearm. Reactions were monitored for 15 minutes. Results No type-1 allergy was observed. The mean erythema diameter of the wheals after 10 minutes was procaine 8.0 ± 6.4 mm, mepivacaine 7.6 ± 6.3 mm, lidocaine 4.4 ± 4.8 mm, and NaCl 3.7 ± 3.2 mm. The wheal diameter of all substances showed a crescendo-decrescendo phenomenon. The procaine and mepivacaine wheals were significantly larger than those of lidocaine and NaCl. No general signs of hypersensitivity were observed. Diameter and intensity were independent of the injection site, order of injection, age, gender, and body mass index. Conclusion This study shows no higher type-1 allergenicity of the ester-linked LA procaine, compared to the amide-linked LAs lidocaine and mepivacaine, and supports its use in therapy and short-track surgery.

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“…The potential beneficial effect of local anaesthesia on inflammation and immune function has long been suggested. In 2000, Hollmann and Durieux 7 had already addressed the potential anti-inflammatory effects of local anaesthetics, reviewing the literature on local anaesthetic effects on the inflammatory response and especially on inflammatory cells (mainly polymorphonuclear granulocytes but also macrophages and monocytes) 8 . The exact mechanisms of action are not clear but seem to involve a reversible interaction with membrane proteins and lipids, thus regulating cell metabolic activity, migration, exocytosis, and phagocytosis 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Perioperative regional anaesthesia and postoperative longer-term outcomes

Jakobsson

Johnson

2016

F1000Res

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Regional anaesthesia provides effective anaesthesia and analgesia in the perioperative setting. Central neuraxial blocks—that is, spinal and epidural blocks—are well established as an alternative or adjunct to general anaesthesia. Peripheral blocks may be used as part of multimodal anaesthesia/analgesia in perioperative practice, reducing the need for opioid analgesics and enhancing early recovery. Furthermore, regional anaesthesia has increased in popularity and may be done with improved ease and safety with the introduction of ultrasound-guided techniques. The effects of local anaesthetics and regional anaesthesia on long-term outcomes such as morbidity, mortality, the quality of recovery beyond the duration of analgesia, and whether it can expedite the resumption of activities of daily living are less clear. It has also been suggested that regional anaesthesia may impact the risk of metastasis after cancer surgery. This article provides an overview of current evidence around quality of recovery, risk for delirium, long-term effects, and possible impact on cancer disease progression associated with the clinical use of local and regional anaesthetic techniques. In summary, there is still a lack of robust data that regional anaesthesia has a clinical impact beyond its well-acknowledged beneficial effects of reducing pain, reduced opioid consumption, and improved quality of early recovery. Further high-quality prospective studies on long-term outcomes are warranted.

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Local Anesthetic–Induced Inhibition of Human Neutrophil Priming

Cited by 30 publications

References 14 publications

Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination

Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination

Local Anesthetics, Procaine, Lidocaine, and Mepivacaine Show Vasodilatation but No Type 1 Allergy: A Double-Blind, Placebo-Controlled Study

Perioperative regional anaesthesia and postoperative longer-term outcomes

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