Local anesthetic effects of cocaine and several extracts of the coca leaf (E. coca)

Bedford, John A.; Turner, Carlton E.; ElSohly, Hala N.

doi:10.1016/0091-3057(84)90207-7

Cited by 8 publications

(8 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on its blocking effect on nerve conduction (Matthews & Collins, 1983;Bedford et al, 1984), cocaine is used topically on the glans penis to decrease sensitivity and prolong erection time (Mahler et al, 1988;Rodriguez-Blazquez et al, 1990). Our data, nonetheless, suggest that cocaine may not share the same mechanism of action with the local anaesthetic, lignocaine, in its influence on ICP.…”

Section: Discussionmentioning

confidence: 99%

“…Our third series of experiments examined the role of the well known local anaesthetic action of cocaine (Bedford et al, 1984) in its elicitation of penile erection. We evaluated the response of ICP to i.c.…”

Section: Animal Preparationmentioning

confidence: 99%

“…In terms of pharmacological actions, cocaine is known to be a local anaesthetic (Bedford et al, 1984) and a central nervous stimulant (Van Dyke & Byck, 1977;Commissaris, 1989). The former action arises from its blockade of sodium channels on the neuronal membrane (Matthews & Collins, 1983).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nitric oxide as a mediator of cocaine‐induced penile erection in the rat

Chan

Huang²,

Chan³

1996

British J Pharmacology

View full text Add to dashboard Cite

1 The effect of local application of cocaine to the corpus cavernosum on intracavernous pressure (ICP), an experimental index for penile erection, was examined in Sprague-Dawley rats anaesthetized with chloral hydrate. The potential involvement of dopamine, noradrenaline or nitric oxide as the chemical mediator in this process, and the pharmacological action of cocaine as a local anaesthetic in the induced increase in ICP, were also investigated. Whereas lignocaine (4 pmol, i.c.) depressed penile erection induced by papaverine (400 gg, i.c.), local application of cocaine (160 pg) into the corpus cavernosum still elicited significant elevation in ICP in the presence of lignocaine or papaverine. 6 The increase in ICP induced by cocaine (160 Mg, i.c.) was attenuated dose-dependently by prior cavernosal administration of the NO synthase inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME, 0.5, 1 or 5 pmol) or NG-monomethyl-L-arginine (L-NMMA, 2.5, 5 or 10 pmol). The blunting effect of L-NAME or L-NMMA was reversed by co-administration of the NO precursor, L-arginine (1 nmol, i.c.). 7 Pretreatment by local application into the corpus cavernosum of methylene blue (2.5 ,mol), an inhibitor of cytosolic guanylyl cyclase, antagonized cocaine-induced penile erection. 8 Direct i.c. administration of a NO donor, nitroglycerin (10 or 20 nmol), mimicked the local action of cocaine by promoting a significant increase in ICP. 9 It is concluded that cocaine may induce penile erection by increasing ICP via a local action on the corpus cavernosum. This process did not appear to involve either dopamine or noradrenaline as the chemical mediator, nor the pharmacological action of cocaine as a local anaesthetic. On the other hand, it is likely that initiation and maintenance of penile erection elicited by cavernosal application of cocaine engaged an active participation of NO and subsequent activation of guanylyl cyclase in the corpus cavernosum.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Animal Preparationmentioning

confidence: 99%

See 1 more Smart Citation

Nitric oxide as a mediator of cocaine‐induced penile erection in the rat

Chan

Huang²,

Chan³

1996

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…To address further this issue, the effects of opioids having different chemical structures (morphine, codeine, ethylmorphine and dihydrocodeine) on CAPs were examined by applying the air-gap method to the frog sciatic nerve. These results were quantitatively compared with those of a local anaesthetic cocaine which is well-known to block AP conduction (Bedford et al, 1984;Brodin and Skoglund, 1990;Pagala et al, 1991; for review see Carney, 1955).…”

Section: Introductionmentioning

confidence: 98%

Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures

et al. 2008

View full text Add to dashboard Cite

“…CNS stimulant (Seidler, 2001); lack of appetite (Burczynski et al, 1986;Vee et al, 1983); anesthetic (Bedford et al, 1984).…”

Section: -21 Elephantopus Mollismentioning

confidence: 99%

Brazilian plants with possible action on the central nervous system—A study of historical sources from the 16th to 19th century

Giorgetti

Negri

Rodrigues

2007

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological research when grounded on historic literature has for its objective retrieving traditional knowledge compiled throughout history by early cultures. The current study has used literature from the 16 th to the 19 th centuries to assess reports that include accounts of Brazil's native plants, with possible reports of disorders of the Central Nervous System (CNS). Visits were paid to 27 institutions located in four Brazilian states. This resulted in raising 529 publications, out of which 65 were read, revealing that 33 of them contained reports of plants exerting effects on CNS ailments. These plants' scientific names underwent an updating process. The updating process resulted in 788 species names (129 correct scientific names and their 659 synonyms) out of which 66 hold current ethnopharmacology, pharmacology studies and/or patent application. Coincidences among past and present data have been observed in 46 cases. Only three of them carried applications for patents all of which coincided with past uses. There have hardly been any studies whatsoever throughout the centuries for many of the species currently being studied. Although of very seldom use, research in ethnopharmacology and historic literature can be promising tools for the selecting of new pharmaco products, further to contributing with retrieving traditional knowledge.

show abstract

Local anesthetic effects of cocaine and several extracts of the coca leaf (E. coca)

Cited by 8 publications

References 3 publications

Nitric oxide as a mediator of cocaine‐induced penile erection in the rat

Nitric oxide as a mediator of cocaine‐induced penile erection in the rat

Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures

Brazilian plants with possible action on the central nervous system—A study of historical sources from the 16th to 19th century

Contact Info

Product

Resources

About